Abstract: Disclosed herein is a method for classifying a patient at risk for heart failure, wherein the method comprises the steps of (i) measuring the concentration of IGFBP2 in a sample obtained from the patient and (ii) comparing the concentration of IGFBP2 measured in step (i) to a control value derived from the concentration of IGFBP2 in samples from patients who are at particular stages of heart failure and/or to a control value derived from the concentration of IGFBP2 in blood samples from healthy patients.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
July 13, 2021
Assignees:
INSERM (INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
Inventors:
Philippe Rouet, Fatima Smih-Rouet, Franck Desmoulin, Michel Galinier
Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
Type:
Application
Filed:
November 16, 2012
Publication date:
September 12, 2013
Applicants:
INSERM (Institut de la Sante et de la Recherche Medicale), BIOGEN IDEC MA INC.
Inventors:
Anthony Rossomando, Jean-Sebastien Silvestre, Radia Tamarat