Abstract: The present invention relates to a non-genetic, detergent-free, bacteria-free method for reprogramming a eukaryotic cell, in particular for obtaining induced pluripotent stem cells (iPS), by using engineered microvesicles carrying at least one reprogramming transcription factor, wherein said engineered microvesicles are virus-free.
Type:
Application
Filed:
November 10, 2010
Publication date:
February 7, 2013
Applicant:
INSERM (Institut National de la Sante et de la Recherche Midicale)
Inventors:
Philippe Mangeot, Vincent Lotteau, Marc Peschanski, Mathilde Girard