Patents Assigned to Inserm
  • SILYLATED BIOMOLECULE-BASED HYDROGEL FOR CULTURING CARDIOMYOCYTES AND STEM CELLS, AND USE OF THE HYDROGEL THEREOF FOR TREATING HEART FAILURE
    Publication number: 20180221493
    Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 9, 2018
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Nantes, CHU Nantes
    Inventors: Pierre Weiss, Eva Mathieu, Jerome Guicheux, Patricia Lemarchand
  • Antagonists of CB1 receptor
    Patent number: 10040816
    Abstract: The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: August 7, 2018
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Bordeaux
    Inventors: Pier Vincenzo Piazza, Monique Vallee, Giovanni Marsicano, Francois-Xavier Felpin, Luigi Bellocchio, Daniela Cota, Jean-Michel Revest, Sergio Vitiello, Umberto Spampinato, Rafael Maldonado
  • Biomarkers of mineralocorticoid receptor activation
    Patent number: 10041122
    Abstract: The present invention relates to the use of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and/or SERPINA3 as biomarkers of the Mineralocorticoid Receptor (MR) activation in a patient. More particularly, the present invention relates to a method for predicting the responsiveness of a patient to a treatment with a MR antagonist or an aldosterone synthase inhibitor, said method comprising determining in a biological sample obtained from said patient the expression level of the NGAL gene and/or of the SERPINA3 gene.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: August 7, 2018
    Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Frederic Jaisser, Nicolette Farman, Yannis Sainte-Marie, Celine Latouche, Marja Steenman
  • ACOUSTIC-OPTICAL IMAGING METHODS AND SYSTEMS
    Publication number: 20180217051
    Abstract: The invention relates to an acoustic-optical imaging method and system of a zone for observing an environment. The system includes an acquisition device comprising, a network of transducers for generating a plurality of non-focussed sound waves, a light-emitting device for emitting an incident light wave and generating marked light waves comprising an acoustic-optical component that is shifted in frequency by the non-focussed sound waves, and a detector for acquiring measurement signals. The system also comprises a processing device for determining a light intensity in the observation zone from the measurement signals.
    Type: Application
    Filed: June 2, 2015
    Publication date: August 2, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE- INSERM
    Inventors: François Ramaz, Mickaël Tanter, Jean-Baptiste Laudereau, Jean-Luc Gennisson
  • NOVEL ADAMANTANE AND MEMANTINE DERIVATIVES AS PERIPHERAL NMDA RECEPTOR ANTAGONISTS
    Publication number: 20180215699
    Abstract: The present invention relates to cationic compounds of formula (I) for use as peripheral NMDA receptor antagonists.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Applicants: Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique-Hôpitaux De Paris, Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud
    Inventors: Marc Humbert, Sylvia Cohen-Kaminsky, Sébastien Dumas, Gilles Bru-Mercier, Mouad Alami, Jean-Daniel Brion, Samir Messaoudi, Gilles Galvani
  • Gene signatures of inflammatory disorders that relate to the liver
    Patent number: 10036074
    Abstract: This invention is related to the area of characterization of inflammation in relation with the gut microbiota, in metabolic and autoimmune disorders. In particular, it relates to the identification of gene signatures which can be used as a marker predictive of inflammation associated diseases, such as liver-related metabolic disorders, in particular to the evolution of benign steatosis towards its most severe forms (steatohepatitis and cirrhosis) or autoimmune disorders, in particular inflammatory bowel diseases (Crohn's and Ulcerative Colitis). These gene signatures can therefore be used as a means of diagnosis, prognosis, stratification for drug studies, for monitoring patient and for assigning an appropriate treatment.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: July 31, 2018
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Matthieu Pichaud, Pierre Rimbaud, Stanislav Ehrlich
  • Methods for the prevention and the treatment of rapidly progressive glomerulonephritis
    Patent number: 10034868
    Abstract: The present invention relates to the prevention and the treatment of rapidly progressive glomerulonephritis.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: July 31, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS DESCARTES
    Inventors: Pierre-Louis Tharaux, Carole Henique Greciet, Guillaume Bollee
  • Nano-reservoirs technology for use in bone and/or cartilage regeneration
    Patent number: 10034737
    Abstract: The present invention concerns a biomaterial comprising a nanofibrous scaffold made of polymers, such as poly(?-caprolactone) or collagen, coated with at least one layer pair consisting of a layer of polyanions and a layer of polycations, wherein said at least one layer pair incorporates a therapeutic molecule such as a growth factor. The biomaterial may optionally comprise living cells such as osteoblasts and/or chondrocytes.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: July 31, 2018
    Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Nadia Benkirane-Jessel, Didier Mainard, Carlos Mendoza Palomares
  • METHOD FOR DOWNSAMPLING A SIGNAL OUTPUTTED BY AN ASYNCHRONOUS SENSOR
    Publication number: 20180207423
    Abstract: Disclosed is a method for processing asynchronous signals generated by a light sensor, the sensor having a matrix of pixels, the method including: —receiving the asynchronous signals, each signal being associated with a pixel in a group of pixels in the matrix, each signal including successive events issued by the associated pixel; —upon an occurrence of an event in one of the asynchronous signals, updating an integration value associated to the group by adding an additive value to the integration value; —if the integration value is greater than a predetermined threshold, generating an event in an outputted asynchronous signal.
    Type: Application
    Filed: July 18, 2016
    Publication date: July 26, 2018
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Ryad BENOSMAN, Francesco GALLUPI, Guillaume CHENEGROS, Xavier LAGORCE, Christoph POSCH
  • METHOD FOR PREDICTING THE OUTCOME OF COLON CANCER BY ANALYSING MIRNA EXPRESSION
    Publication number: 20180208995
    Abstract: The present invention relates to a method for predicting the outcome of a cancer. More particularly, the present invention relates to a method for predicting the outcome of a cancer in a patient comprising a step consisting of determining the expression level of a miRNA cluster in a sample obtained from said patient, wherein said miRNA cluster comprises: -miR.609 or, -miR.518c or, -miR.520f or, -miR.220a or, -miR.362 or, -miR.29a or, -miR.660 or, -miR.603 or, -miR.558 or, -miR519b or, -miR.494 or, -miR.130a or, -miR.639.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 26, 2018
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), UNIVERSITÉ PARIS DESCARTES, ASSISTANCE PUBLIQUE -HÔPITAUX DE PARIS (APHP)
    Inventors: Jérôme GALON, Bernhard MLECNIK, Franck PAGES, Hervé FRIDMAN
  • Synthetic single domain antibody
    Patent number: 10030068
    Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 24, 2018
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Institut Curie, Universite Paul Sabatier Toulouse III, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Aurelien Olichon, Sandrine Moutel, Franck Perez
  • Insonification Method for Obtaining a Predetermined Field of Ultrasonic Waves and Production Method for Making an Ultrasonic Lens for These Purposes
    Publication number: 20180192990
    Abstract: In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.
    Type: Application
    Filed: June 30, 2016
    Publication date: July 12, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Mickaël Tanter, Jean-François Aubry, Thomas Deffieux, Mathieu Pernot
  • METHOD FOR THE DIAGNOSIS OF DISORDERS CAUSED BY FETAL ALCOHOL SYNDROME
    Publication number: 20180195124
    Abstract: The present invention provides a method for the diagnosis of disorders caused by foetal alcohol syndrome, said method comprising the assaying of PLGF (placental growth factor).
    Type: Application
    Filed: June 22, 2016
    Publication date: July 12, 2018
    Applicants: Centre Hospitalier Universitaire De Rouen, Universite De Rouen Normandie, Institut National De La Sante Et De La Recherche Medicale (INSERM)
    Inventors: Bruno José Gonzalez, Stéphane Marret, Matthieu Jean Alexandre Lecuyer, Annie Laquerriere, Soumeya Bekri, Céline Lesueur, Sylvie Marguerite Alberte Jegou, Pascale Yvonne Joséphine Marcorelles
  • Synthetic single domain antibody
    Patent number: 10017559
    Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: July 10, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, INSTITUT CURIE, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Aurellen Olichon, Sandrine Moutel, Franck Perez
  • 1,4-bis(3-aminopropyl)piperazine derivative and its use
    Patent number: 10017476
    Abstract: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: July 10, 2018
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU), UNIVERSITE DE LILLE 2 DROIT ET SANTE
    Inventors: Nicolas Sergeant, Luc Buee, Patricia Melnyk, Marion Gay, Nicolas Le Fur
  • Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus
    Patent number: 10018629
    Abstract: A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16-specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: July 10, 2018
    Assignees: INSTITUTE PASTEUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DIDEROT-PARIS 7, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Marie-Lise Gougeon, Manuelle Viguier, Hervé Bachelez, Nicolas Fazilleau
  • Method and pharmaceutical composition for use in the treatment of epilepsy
    Patent number: 10016424
    Abstract: The present invention relates to a compound which is an antagonist of the GluK2/GluK5 receptor or an inhibitor of the GluK2/GluK5 receptor expression for use in the treatment or the prevention of epilepsy.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: July 10, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BORDEAUX
    Inventors: Valerie Crepel, Christophe Mulle, Angelique Peret
  • Lipophenol compounds and uses thereof
    Patent number: 10011620
    Abstract: The present invention relates to a compound of formula (I) wherein: i is 0 or 1; j is 0 or 1; k is 0 or 1; R1 and R2 are in particular H, (C1-C12)alkyl, or a group of formula C(O)R; R is a, linear or branched, alkyl radical, comprising at least 19 carbon atoms; R3 is H and k=0 when j=1; or, when j=0, R3 is —C(O)R or -L-C(O)R; L, U and L? are linkers; wherein, when j=0, at least one of the groups R1; R2 and R3 comprises a radical R.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: July 3, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER, UNIVERSITE D'AUVERGNE, UNIVERSITE DE MONTPELLIER
    Inventors: Philippe Brabet, David Cia, Laurent Guillou, Christian Hamel, Claire Vigor, Thierry Durand, Céline Crauste, Joseph Vercauteren
  • Method for producing methane by means of aerobic co-culture of anaerobic micro-organisms
    Patent number: 10011852
    Abstract: The present invention relates to the biological production of methane (Biogas) by co-culture in an aerobic atmosphere of a methanogenic bacterium and of an anaerobic bacterium capable of producing hydrogen, in a culture medium comprising or being supplemented with carbohydrate compound(s), notably starch and/or sugars, and supplemented with antioxidant compound(s).
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: July 3, 2018
    Assignees: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Didier Raoult, Saber Khelaifia, Michel Drancourt
  • Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune response
    Patent number: 10010607
    Abstract: The present invention relates to methods for preparing virus-like particles comprising immunogenic cyclic dinucleotides.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: July 3, 2018
    Assignees: INSTITUT CURIE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Nicolas Manel, Matteo Gentili, Satoh Takeshi, Jan Rehwinkel, Anne Bridgeman, Tamara Davenne, Jonathan Maelfait