Patents Assigned to Inserm
  • USE OF FSH RECEPTOR LIGANDS FOR DIAGNOSIS AND THERAPY OF CANCER
    Publication number: 20100316572
    Abstract: The present invention relates to diagnostic imaging and in particular to the diagnostic imaging and therapy of cancer by means of compositions which specifically target the FSH Receptor expressed by tumor endothelial cells and circulating blood cells.
    Type: Application
    Filed: February 18, 2009
    Publication date: December 16, 2010
    Applicants: Institut National De La Sante Et De La Recherche Medicale (Inserm), Mount Sinai School of Medicine
    Inventors: Nicolae Ghinea, Aurelian Radu
  • Non-Conventional NKT Cells for Use in Cancer Therapy
    Publication number: 20100303779
    Abstract: The invention relates to the use of CD Id-independent NKT cells, for the preparation of a pharmaceutical composition for treating a tumor in a patient. Said CD1d-independent NKT cells may be obtained by (a) culturing a population of T cells under conditions which suppress TGF? signalling pathway, and (b) selecting the cells which exhibit at least one NK marker.
    Type: Application
    Filed: October 3, 2008
    Publication date: December 2, 2010
    Applicant: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventor: Julien Marie
  • Antibodies Against Human CD39 and Use Thereof for Inhibiting T Regulatory Cells Activity
    Publication number: 20100303828
    Abstract: The invention relates to antibodies against human CD39 and use thereof for inhibiting T regulatory cells (Treg) activity. More particularly CD39 antibodies may be used for the treatment or prevention of cancers and infectious diseases.
    Type: Application
    Filed: January 30, 2009
    Publication date: December 2, 2010
    Applicant: INSERM Institut National de la Sante et de la Recherche Medicale)
    Inventors: Yves Levy, Jean-Francois Eliaou, Armand Bensussan, Nathalie Bonnefoy-Berard
  • Method for Analysing an Image of the Brain of a Subject, Computer Program Product for Analysing Such Image and Apparatus for Implementing the Method
    Publication number: 20100303318
    Abstract: Method for analysing an image of the brain of a subject, comprising: collection of an image in at least three dimensions of the brain of a subject, parcellation of said image into regions of interest (ROIs) in a brain native reference frame characteristic of said brain, determination in an automated manner, for each ROI, of at least one discriminating value based on image data measured on the image, said image data being representative of an anatomical or functional feature of the brain, said discriminating value being relative with regard to the discriminating values of the other ROIs.
    Type: Application
    Filed: May 6, 2008
    Publication date: December 2, 2010
    Applicant: INSERM (Institut Natioal de la Recherche Medicale)
    Inventors: Habib Benali, Stephane Lehericy, Benoit Magnin, Bruno Dubois
  • Aqueous-Core Lipid Nanocapsules for Encapsulating Hydrophilic and/or Lipophilic Molecules
    Publication number: 20100297247
    Abstract: The invention relates to a composition comprising in an aqueous phase, particles having a diameter in the range of 20 to 500 nm, said particles containing:—an oil phase;—in said oil phase,—an aqueous droplet, or—a nanocapsule (NC) comprising:—an aqueous core, and—a polymeric shell or a shell composed of an amphiphilic substance; and—a surfactant. This composition is particularly useful for encapsulating hydrophilic and/or lipophilic substances.
    Type: Application
    Filed: September 18, 2008
    Publication date: November 25, 2010
    Applicant: Institut National de la Sante et de la Recherche Medicale (Inserm)
    Inventors: Nicolas Anton, Patrick Saulnier, Jean-Pierre Benoit
  • Detection of tuberculosis and infection by using HBHA
    Patent number: 7833699
    Abstract: The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: November 16, 2010
    Assignees: Institute Pasteur de Lille, Inserm (Institut National de la Sante Et de la Recherche Medicale), Universite Libre de Bruxelles, Universite du Droit Et de la Sante de Lille II
    Inventors: Camille Locht, Françoise Mascart, Stéphane Temmerman, Jean-Michel Hougardy, Sammy Place, Christian Sergheraert
  • Methods for the Treatment and Diagnosis of Bone Mineral Density Related Diseases
    Publication number: 20100284991
    Abstract: The present invention relates to methods of the treatment and diagnosis of bone mineral density related disorders. More particularly, the present invention relates to a method of diagnosing or predicting a bone mineral density related disease, or a risk of a bone mineral density related disease, in a subject, which method comprises detecting a mutation in the TBXAS1 gene, wherein the presence of said mutation is indicative of a bone mineral density related disease or of a risk of a bone mineral density related disease. The invention also relates to a compound selected in the group consisting of a thromboxane synthase (TXAS) encoding polynucleotide, a TXAS, thromboxane A2 or an analog thereof for treating or preventing a disease associated with an increased bone mineral density (e.g., Ghosal hematodiaphyseal dysplasia syndrome).
    Type: Application
    Filed: December 5, 2008
    Publication date: November 11, 2010
    Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Valerie Cormier-Daire, Arnold Munnich
  • MEDICAMENTS AND METHODS FOR TREATING MESOTHELIOMA
    Publication number: 20100278872
    Abstract: The present invention relates to the use of at least one attenuated measles virus for the manufacture of a medicament intended for treating malignant mesothelioma in an individual.
    Type: Application
    Filed: October 10, 2008
    Publication date: November 4, 2010
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCH MEDICALE (INSERM), INSTITUT PASTEUR
    Inventors: Anne Gauvrit, Frédéric Tangy, Marc Gregoire
  • Inhibitors of MRP4 for the Treatment of Vascular Disorders
    Publication number: 20100278809
    Abstract: The invention relates to inhibitors of MRP4 for the treatment and/or the prevention of vascular disorders such as atherosclerosis, post-angioplasty restenosis, pulmonary arterial hypertension or vein-graft disease.
    Type: Application
    Filed: April 10, 2008
    Publication date: November 4, 2010
    Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Jean-Sebastien Hulot, Anne-Marie Lompre, Yassine Sassi, Philippe Lechat
  • Use of a protein of the CRMP family for treating diseases related to the immune system
    Patent number: 7820375
    Abstract: The invention concerns the use of at least a protein of the CRMP family, a polypeptide fragment or an active biological derivative thereof, a nucleotide sequence or sequence fragment coding for said protein, an antisense sequence capable of being specifically hybridized with a sequence with nucleotide-type encoding of said protein or an antibody directed against said protein for producing a medicine for treating diseases related to a dysfunction of the immune system. The invention also concerns a method for diagnosing an autoimmune pathology which consists in measuring the expression of a CRMP protein in the lymphocytes.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: October 26, 2010
    Assignee: Institut National de la Sante Et de la Recherche Medicale (Inserm)
    Inventors: Pascale Giraudon, Marie-Françoise Belin, Christophe Malcus, Pierre Colas, Jean-Christophe Antoine, Jérôme Honnorat
  • Trophic Factor for the Treatment of Retinal Degenerative Diseases
    Publication number: 20100267646
    Abstract: This invention relates to methods and compositions for detection and treatment of retinal degenerative diseases. In particular, the invention relates to polypeptides that can protect against cone degeneration, nucleic acid molecules that encode such polypeptides, and antibodies that recognize said polypeptides.
    Type: Application
    Filed: December 5, 2008
    Publication date: October 21, 2010
    Applicant: INSERM (institut national de la Sante et de la Rec
    Inventors: Thierry Leveillard, Jose-Alain Sahel, Valerie Fontaine
  • Methods for Producing a Non Human Model for Aortic Aneurysm
    Publication number: 20100260726
    Abstract: The present invention relates to methods for producing a non human animal model for aortic aneurysm which could provide insight into the diagnosis and treatment of said disease. Furthermore, the present invention relates to methods and compositions for the treatment or the prevention of aneurysm in a subject in need thereof.
    Type: Application
    Filed: September 30, 2008
    Publication date: October 14, 2010
    Applicant: INSERM
    Inventors: Pierre Louis Tharaux, Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat
  • METHOD FOR MEASURING THE PLASMINE ACTIVITY OF MICROPARTICLES PRESENT IN A SAMPLE OF A BIOLOGICAL FLUID AND USE THEREOF
    Publication number: 20100260724
    Abstract: The invention relates to a method for measuring the plasmine activity of microparticles, in particular circulating microparticles, in a sample of a biological fluid, particularly a biological fluid in a flow situation, wherein said method can be used as a diagnosis method or a method for following a treatment.
    Type: Application
    Filed: June 6, 2008
    Publication date: October 14, 2010
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE -HOPITAUX DE MARSEILLE, UNIVERSITE DE LA MEDITERRANEE, UNIVESITE DE CAEN BASSE- NORMANDIE
    Inventors: Eduardo Angles Cano, Romaric Lacroix, Florence Malaterre, Francoise Dignat-George
  • COMPOSITIONS AND METHODS FOR INCREASING VASCULARIZATION
    Publication number: 20100261654
    Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
    Type: Application
    Filed: May 1, 2008
    Publication date: October 14, 2010
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), Biogen Idec MA Inc.
    Inventors: Anthony Rossomando, Jean-Sebastien Silvestre, Radia Tamarat
  • ULTRASOUND TREATMENT DEVICE AND METHOD
    Publication number: 20100256534
    Abstract: A method for treating a varicose vein comprises heating a dehiscent portion of a wall of the vein so as to produce a localized retraction of collagen. Heating may be via application of high-intensity focused ultrasound energy.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 7, 2010
    Applicants: INSERM, THERACLION
    Inventors: Francois Lacoste, Jean-Yves Chapelon, Olivier Pichot, Réné Milleret, Samuel Pichardo
  • NEURONAL VIABILITY FACTOR AND USE THEREOF
    Publication number: 20100247496
    Abstract: The present disclosure concerns a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected in the group comprising (i) a polypeptide comprising an amino acid sequence selected in the group comprising the amino acid sequence of the long isoform in Homo sapiens of the RdCVF2 gene (SEQ ID NO:10), orthologs, derivatives and fragments thereof, (ii) a polynucleotide coding for said polypeptide, (iii) a vector comprising said polynucleotide, and (iv) a host cell genetically engineered expressing said polypeptide; the use of such a composition for the manufacture of a medicament for treating and/or preventing a neurodegenerative disorder in a subject; and a method of testing a subject thought to have or be predisposed to having a neurodegenerative disorder.
    Type: Application
    Filed: June 5, 2008
    Publication date: September 30, 2010
    Applicant: Institute National De La Sante ET De Las Recherche Medicale (INSERM)
    Inventors: Thierry Leveillard, José-Alain Sahel, Céline Jaillard, Olivier Poch
  • MUTATED NETRIN 4, FRAGMENTS THEREOF AND USES THEREOF AS DRUGS
    Publication number: 20100247520
    Abstract: The present invention relates to a protein comprising or consisting of one of the following sequences: the sequence SEQ ID NO: 2 or SEQ ID NO: 4, or a fragment of said sequence represented by one of the sequences SEQ ID NO: 2q, q varying from 3 to 36, or the sequence SEQ ID NO: 185 to SEQ ID NO: 209. It also relates to a nucleotide sequence coding for said protein.
    Type: Application
    Filed: January 21, 2008
    Publication date: September 30, 2010
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, IVS INSTITUT DES VAISSEAUX ET DU SANG, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC
    Inventors: Jean Plouet, Isabelle Clarisse Solange Plouet, Claire Charlotte Plouet, Anne Florence Plouet, Laurence Leconte, Esma Lejmi
  • CONSTITUTIVELY ACTIVE MUTANTS OF THE PROLACTIN RECEPTOR
    Publication number: 20100240033
    Abstract: The invention relates to constitutively active mutants of the prolactin receptor (PRLR), wherein an Ile residue at position 76 or at position 146 of the mature form of said receptor has been substituted by another amino acid residue. The invention also provides methods useful for the diagnosis, prognosis, or treatment of diseases involving the PRLR.
    Type: Application
    Filed: March 20, 2007
    Publication date: September 23, 2010
    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM)
    Inventors: Vincent Goffin, Philippe Touraine
  • USE OF THE PROTIEN MABA (FABG1) OF MYCOBACTERIUM TUBERCULOSIS FOR DESIGNING AND SCREENING ANTIBIOTICS
    Publication number: 20100240084
    Abstract: The protein MabA, also named protein FabG1, which is recombinant in a purified form, or the recombinant proteins derived from the protein MabA by mutation of at least one amino acid. The uses of proteins MabA, or recombinant proteins derived from protein MabA by mutation of at lease one amino acid, proteins and to the crystalloghraphis co-ordinates thereof, in terms of the implementation of methods for designing and screening ligands of these proteins, and advantageously, ligands inhibiting the enzymatic activity of these proteins.
    Type: Application
    Filed: April 14, 2009
    Publication date: September 23, 2010
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE MONTPELLIER 1
    Inventors: Annaik QUEMARD, Gilles Labesse, Mamadou Daffe, Hedia Marrakchi, Dominique Douguet, Martin Cohen-Gonsaud, Stephanie Ducasse
  • METHODS OF ASSESSING A PROPENSITY OF CLINICAL OUTCOME FOR A FEMALE MAMMAL SUFFERING FROM BREAST CANCER
    Publication number: 20100234292
    Abstract: The present invention relates to a method of assessing a propensity of clinical outcome for a female mammal suffering from breast cancer in view of the expression of specific nucleic acid sequences in a biological sample.
    Type: Application
    Filed: April 16, 2008
    Publication date: September 16, 2010
    Applicants: IPSOGEN, INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RE CHECHE MEDICALE, INSTITUT PAOLI-CALMETTES
    Inventors: Francois Bertucci, Daniel Birnbaum, Patrice Viens, Vincent Fert, Fabienne Hermitte, Stephane Debono, Stephane Deraco, Nathalie Borie, Fanny Piette