Patents Assigned to InSight Biopharmaceuticals Ltd.
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Patent number: 8048993Abstract: According to the present invention there is provided an antibody that specifically binds an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at position 246. The present invention also provides an antibody elicited by an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at position 246.Type: GrantFiled: January 4, 2008Date of Patent: November 1, 2011Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
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Publication number: 20110150820Abstract: Conjugates of polypeptides and a polymeric moiety such as PEG covalently attached to the sulfur atom of a methionine side chain are disclosed. Processes of preparing such conjugates, including intermediates and reagents utilized therefore are also disclosed. Further disclosed are therapeutic uses of these conjugates.Type: ApplicationFiled: August 27, 2009Publication date: June 23, 2011Applicant: Insight Biopharmaceuticals Ltd.Inventors: Joel M. Van Gelder, Andrei Serban, Susanna Tchilibon, Daphna Miron
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Patent number: 7893240Abstract: The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5?-UTR sequence and a truncated 3?-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.Type: GrantFiled: July 25, 2008Date of Patent: February 22, 2011Assignee: InSight Biopharmaceuticals Ltd.Inventor: Iris Pecker
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Patent number: 7795255Abstract: Disclosed are novel rigidified compounds having a rhodanine-like residue and at least one aryl or heteroaryl residue linked to the rhodanine-like residue, whereby a core structure of these compounds, as defined in the specification, is characterized as having one or zero free-to-rotate bonds. Also disclosed are pharmaceutical compositions containing these rigidified compounds and uses thereof for modulating the activity of heparanase and hence in the treatment of heparanase-associated diseases and disorders, and uses thereof for modulating the activity of heparin-binding proteins and hence in the treatment of heparin-binding proteins-associated diseases and disorders as well as in the treatment of medical conditions that are at least partially treatable by rhodanine or a rhodanine analog.Type: GrantFiled: January 5, 2006Date of Patent: September 14, 2010Assignee: InSight Biopharmaceuticals Ltd.Inventors: Joel M. Van Gelder, Joseph Y. Klein, Yochai Basel, Anat Reizelman, Susanna Tchilibon, Orly Mouallem
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Patent number: 7790376Abstract: Heparanase specific molecular probes which can be used for detection of the presence, absence or level of heparanase expression and methods of utilizing same are provided.Type: GrantFiled: May 24, 2004Date of Patent: September 7, 2010Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
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Patent number: 7666651Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.Type: GrantFiled: February 6, 2001Date of Patent: February 23, 2010Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Elena Feinstein
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Publication number: 20090099341Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.Type: ApplicationFiled: January 4, 2008Publication date: April 16, 2009Applicants: InSight Biopharmaceuticals Ltd., Hadasit Medical Research ServicesInventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
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Publication number: 20080312179Abstract: The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5?-UTR sequence and a truncated 3?-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.Type: ApplicationFiled: July 25, 2008Publication date: December 18, 2008Applicant: InSight Biopharmaceuticals Ltd.Inventor: Iris Pecker
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Patent number: 7423139Abstract: The present invention provides an expression construct capable of producing high levels of erythropoietin in mammalian cells. More particularly, the expression construct includes an erythropoietin coding region fused to a unique 5?-UTR sequence and a truncated 3?-UTR. The present invention also provides methods of synthesizing large amounts of erythropoietin and in increasing serum erythropoietin level in individuals in need thereof.Type: GrantFiled: January 20, 2004Date of Patent: September 9, 2008Assignee: InSight Biopharmaceuticals Ltd.Inventor: Iris Pecker
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Patent number: 7339038Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.Type: GrantFiled: October 2, 2003Date of Patent: March 4, 2008Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
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Patent number: 7101706Abstract: The present invention relates to novel polynucleotides encoding polypeptides homologous to heparanase, nucleic acid constructs including these novel polynucleotides, genetically modified cells expressing the same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotides, analogs thereof and ribozymes derived from these polynucleotides.Type: GrantFiled: June 19, 2000Date of Patent: September 5, 2006Assignee: InSight Biopharmaceuticals Ltd.Inventors: Iris Pecker, Israel Michal, Hanan Itzhaki
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Patent number: 7049407Abstract: A variety of heparanase specific antibodies which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific antibodies for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific antibodies for therapy of a condition associated with expression of heparanase; the use of a heparanase specific antibodies for quantification of heparanase in a body fluid; the use of a heparanase specific antibodies for targeted drug delivery; and the use of a heparanase specific antibodies as a therapeutic agent.Type: GrantFiled: January 16, 2001Date of Patent: May 23, 2006Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedman, Tuvia Perets
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Patent number: 6986996Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.Type: GrantFiled: February 26, 2004Date of Patent: January 17, 2006Assignees: Insight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
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Patent number: 6960471Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.Type: GrantFiled: March 10, 2003Date of Patent: November 1, 2005Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Elena Feinstein
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Patent number: 6800441Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.Type: GrantFiled: September 4, 2001Date of Patent: October 5, 2004Assignees: Insight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedman, Tuvia Perets
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Patent number: 6790658Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.Type: GrantFiled: November 19, 2001Date of Patent: September 14, 2004Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Elena Feinstein
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Patent number: 6699672Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.Type: GrantFiled: November 3, 2000Date of Patent: March 2, 2004Assignees: InSight Biopharmaceuticals Ltd., Hadasit Medical Research Services and Development Ltd.Inventors: Iris Pecker, Israel Vlodavsky, Yael Friedman, Tuvia Perets