Patents Assigned to Insight Genetics, Inc.
  • Patent number: 9428812
    Abstract: Disclosed are methods and kits for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR) techniques to detect the presence of point mutations, truncations, or fusions of anaplastic lymphoma kinase.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: August 30, 2016
    Assignee: Insight Genetics, Inc.
    Inventors: David R. Hout, Rachel Skelton, John Handshoe, Kasey Lawrence, Brock Schweitzer
  • Publication number: 20150240301
    Abstract: Disclosed are methods, assays, and compositions for detecting the presence of a kinase inhibitor resistance. The disclosed method and primer panels work with any method for detecting nucleic acid variation in a sample including, but not limited to next generation sequencing.
    Type: Application
    Filed: September 26, 2013
    Publication date: August 27, 2015
    Applicant: Insight Genetics, Inc.
    Inventors: David Hout, Eric Dahlhauser, Adam Platt
  • Patent number: 7906287
    Abstract: Disclosed are methods and compositions for detecting variation in nucleic acids. The disclosed method compares the sequence of a nucleic acid of interest with the sequence of a reference nucleic acid to sensitively identify variations between the sequence of a nucleic acid of interest and the sequence of a reference nucleic acid. The disclosed method generally involves excision and replacement of selected nucleotides in nucleic acid strands hybridized to other strands. In the method, if the excised nucleotide was mismatched with the nucleotide in the other, hybridized strand, then the replacement nucleotide will not be mismatched. If the excised nucleotide was not mismatched with the nucleotide in the other, hybridized strand, then the excised nucleotide is not replaced. This difference allows detection of variation in the nucleic acid of interest.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: March 15, 2011
    Assignee: Insight Genetics, Inc.
    Inventor: Paul A. Dahlhauser