Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
Type:
Application
Filed:
October 30, 2007
Publication date:
November 5, 2009
Applicants:
Insight Strategy & Marketing Ltd., Hadasit Maedical Research Services and Development Ltd.
Inventors:
Iris Pecker, Israel Vlodavsky, Elena Feinstein
Abstract: Methods of improving embryo implantation are disclosed and comprise contacting a receptive uterus and/or an embryo with an effective amount of heparanase and implanting the embryo in the receptive uterus.
Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and the use of a heparanase specific molecular probe as a therapeutic agent.
Type:
Application
Filed:
October 2, 2003
Publication date:
April 1, 2004
Applicants:
Insight Strategy & Marketing Ltd., Hadasit Medical Research Services and Development Ltd.
Inventors:
Iris Pecker, Israel Vlodavsky, Yael Friedmann, Tuvia Peretz
Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
Type:
Application
Filed:
June 9, 2003
Publication date:
December 25, 2003
Applicants:
Insight Strategy & Marketing Ltd., Hadasit Medical Research Services and Development Ltd.
Inventors:
Iris Pecker, Israel Vlodavsky, Elena Feinstein
Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression are provided.
Type:
Grant
Filed:
November 8, 1999
Date of Patent:
December 16, 2003
Assignees:
Insight Strategy & Marketing Ltd., Hadasit Medical Research Services and Development Ltd.
Inventors:
Iris Pecker, Israel Vlodavsky, Elena Feinstein
Abstract: A method of testing an agent for its potential at modulating induction of a molecular weight change of a first polyion is disclosed. The method is effected by (a) subjecting the first polyion to conditions under-which the first polyion undergoing the molecular weight change in a presence, in an absence or under several different concentrations of the agent; (b) interacting the first polyion with a second polyion having an opposite charge, the second polyion being fluorescently labeled; (c) providing reaction conditions so as to allow molecular weight discriminative interaction between the first polyion and the second polyion; and (d) employing a fluorescence polarization assay for determining a modulating effect of the agent on the induction of the molecular weight change of the first polyion.
Abstract: A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.
Type:
Grant
Filed:
November 4, 1998
Date of Patent:
May 13, 2003
Assignees:
Insight Strategy & Marketing Ltd., Hadasit Medical Research Services and Development Ltd.
Abstract: A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy are disclosed. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level of heparanase expression; the use of a heparanase specific molecular probe for therapy of a condition associated with expression of heparanase; the use of a heparanase specific molecular probe for quantification of heparanase in a body fluid; the use of a heparanase specific molecular probe for targeted drug delivery; and, the use of a heparanase specific molecular probe as a therapeutic agent.
Type:
Grant
Filed:
June 1, 1999
Date of Patent:
March 11, 2003
Assignees:
Insight Strategy & Marketing Ltd., Hadasit Medical Research Services and Development Ltd.
Inventors:
Iris Pecker, Israel Vlodavsky, Yael Friedman, Tuvia Perets
Abstract: A method of inducing bone formation in a subject in need thereof, the method comprises administering to the subject a therapeutically effective amount of heparanase. A pharmaceutical composition for inducing bone formation in a subject in need thereof, the pharmaceutical composition comprises, as an active ingredient, a therapeutically effective amount of heparanase, and a pharmaceutically acceptable carrier.
Abstract: A transgenic animal expressing heparanase from a transgene, methods for its preparation, compositions-of-matter derived therefrom and its uses.
Type:
Application
Filed:
May 25, 2001
Publication date:
December 19, 2002
Applicant:
Insight Strategy & Marketing Ltd.
Inventors:
Eyal Zcharia, Israel Vlodavsky, Shula Metzger, Tova Chajek-Shaul, Orit Goldshmidt, Iris Pecker, Neta Ilan
Abstract: Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
Abstract: A method of testing an agent for its potential at modulating induction of a molecular weight change of a first polyion is disclosed. The method is effected by (a) subjecting the first polyion to conditions under-which the first polyion undergoing the molecular weight change in a presence, in an absence or under several different concentrations of the agent; (b) interacting the first polyion with a second polyion having an opposite charge, the second polyion being fluorescently labeled; (c) providing reaction conditions so as to allow molecular weight discriminative interaction between the first polyion and the second polyion; and (d) employing a fluorescence polarization assay for determining a modulating effect of the agent on the induction of the molecular weight change of the first polyion.
Abstract: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.
Type:
Application
Filed:
February 6, 2001
Publication date:
August 1, 2002
Applicant:
Insight Strategy and Marketing Ltd.
Inventors:
Iris Pecker, Israel Vlodavsky, Elena Feinstein
Abstract: A preparation containing an enzymatically inactive form of heparanase, said enzymatically inactive form of heparanase being cleavable into an enzimatically active form of heparanase.
Abstract: A method of rendering a surface protected bacteria more susceptible to an anti-bacterial agent effected by subjecting the bacteria to a glycosaminoglycans degrading enzyme.
Abstract: Methods and compositions for inducing and/or accelerating wound healing and/or angiogenesis via the catalytic activity of heparanase are disclosed.
Type:
Application
Filed:
December 4, 2000
Publication date:
June 6, 2002
Applicant:
Insight Strategy & Marketing Ltd. and Hadasit Medical Research Services and Development Ltd.
Inventors:
Neta Ilan, Israel Vlodavsky, Oron Yacoby-Zeevi, Iris Pecker
Abstract: Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.