Patents Assigned to InSite Vision, Incorporated
-
Patent number: 9789080Abstract: Ophthalmic formulations including mycophenolic acid or salt thereof in an aqueous medium having a reduced level of dissolved oxygen and processes for making such formulations and using such formulations are disclosed.Type: GrantFiled: September 4, 2015Date of Patent: October 17, 2017Assignees: Insite Vision IncorporatedInventors: Sui Yuen Eddie Hou, Lyle M. Bowman, Tang Nguyen, Gholam Peyman
-
Publication number: 20150190407Abstract: Methods of treating a subject after ocular surgery are disclosed. The methods include administering to an eye of a subject in need thereof a composition comprising at least one corticosteroid or an ophthalmically acceptable salt thereof in an ophthalmically acceptable vehicle that can provide a sustained release of the at least one corticosteroid or an ophthalmically acceptable salt thereof. Advantageously, the composition does not result in a statistically significant elevation in intraocular pressure in a statistically significant number of subject eyes when administered twice daily over a period of two weeks.Type: ApplicationFiled: January 7, 2014Publication date: July 9, 2015Applicant: INSITE VISION INCORPORATEDInventors: Kamran HOSSEINI, Lyle M. BOWMAN
-
Publication number: 20140274924Abstract: Provided is concentrated aqueous azithromycin formulation from about from about 2%-20%, and a method of making a concentrated aqueous azithromycin formulation which includes preparing and sterilizing a first solution comprising a strong base to form a sterilized solution, dissolving the azithromycin in an aqueous solution comprising an acid consisting essentially of a strong acid, and adding the aqueous solution comprising the strong acid to the sterilized solution comprising the strong base. The strong acid has a pKa less than about ?1.74 and the method is carried out without addition or use of a weak acid.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: INSITE VISION INCORPORATEDInventors: Lyle M. Bowman, Sui Yen Eddie Hou, Tang Nguyen
-
Patent number: 8778999Abstract: The disclosure provides compositions and systems for topical ophthalmic application, which include an aqueous mixture of bromfenac and flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.Type: GrantFiled: March 5, 2009Date of Patent: July 15, 2014Assignee: Insite Vision IncorporatedInventors: Kamran Hosseini, Lyle Bowman, Erwin C. Si, Stephen Pham
-
Patent number: 8695850Abstract: A tip arrangement for a bottle used for dispensing viscous liquid, such as drops of medicine, is provided. Embodiments include a tip insert having an insert body and a piercing point at a lower end of the insert body, for piercing a top surface of the bottle and for retaining the tip insert on the top surface of the bottle after piercing. A passage extends from a distal end of the piercing point, through the insert body, to an opposing upper surface of the insert body. A dispensing tip at the insert body upper surface communicates with the passage for precisely forming drops of the liquid from the bottle.Type: GrantFiled: March 6, 2009Date of Patent: April 15, 2014Assignee: Insite Vision IncorporatedInventors: Lyle Bowman, Surendra Patel
-
Publication number: 20130217657Abstract: Compositions and systems for topical ophthalmic application, which include an aqueous mixture of steroidal and non-steroidal anti-inflammatory agents in a flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.Type: ApplicationFiled: March 25, 2013Publication date: August 22, 2013Applicant: INSITE VISION INCORPORATEDInventor: INSITE VISION INCORPORATED
-
Patent number: 8501800Abstract: An ophthalmically acceptable vehicle includes an aqueous suspension having a first viscosity. The suspension includes about 0.1% to about 6.5% by weight of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent. The polymer has average particle size of not more than about 50 ?m in equivalent spherical diameter. The vehicle includes a second polymer that allows the carboxyl-containing polymer to remain suspended. Upon contact with tear fluid, the vehicle gels to a second viscosity which is greater than the first viscosity. A method of administering a medicament to the eye of a subject includes applying a composition that includes this ophthalmically acceptable vehicle and a medicament contained for treatment of a disease or disorder for which ophthalmic delivery is indicated. The medicament is released from the vehicle in a sustained release manner.Type: GrantFiled: March 5, 2009Date of Patent: August 6, 2013Assignee: Insite Vision IncorporatedInventors: Lyle Bowman, Stephen Pham
-
Publication number: 20100305054Abstract: The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.Type: ApplicationFiled: August 12, 2010Publication date: December 2, 2010Applicant: INSITE VISION INCORPORATEDInventors: Lyle Bowman, S. Kumar Chandrasekaran, Roy Duane Archibald, Stephen Pham, David Mufson
-
Patent number: 7795231Abstract: The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.Type: GrantFiled: October 4, 2007Date of Patent: September 14, 2010Assignee: Insite Vision IncorporatedInventors: Lyle Bowman, S. Kumar Chandrasekaran, Roy Duane Archibald, Stephen Pham, David Mufson
-
Patent number: 7749970Abstract: The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.Type: GrantFiled: April 7, 2003Date of Patent: July 6, 2010Assignee: Insite Vision IncorporatedInventors: Chandler R. Dawson, Lyle M. Bowman
-
Patent number: 7732415Abstract: The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.Type: GrantFiled: July 26, 2004Date of Patent: June 8, 2010Assignee: Insite Vision IncorporatedInventors: Chandler R. Dawson, Lyle M. Bowman
-
Patent number: 7141607Abstract: Methods and compositions for the prophylactic and therapeutic treatment of retinal disorders associated with neovascularization using topical ophthalmic compositions comprising hydroxamic acid matrix metalloproteinase inhibitors such as batimastat.Type: GrantFiled: March 10, 2000Date of Patent: November 28, 2006Assignee: Insite Vision IncorporatedInventors: Erwin Si, Lyle M. Bowman
-
Publication number: 20050255506Abstract: Methods of diagnosis of the presence or absence of an NOS-2-associated increased risk of glaucoma, or of a NOS-2-associated decreased risk of glaucoma, are described, in which a sample is tested for the presence of certain alleles of polymorphisms in the promoter of NOS-2, that are associated with an increased risk of glaucoma or with a decreased risk of glaucoma. Also described are methods of therapy of glaucoma, utilizing NOS-2 therapeutic agents.Type: ApplicationFiled: February 16, 2005Publication date: November 17, 2005Applicant: Insite Vision IncorporatedInventor: Claes Wadelius
-
Publication number: 20040266702Abstract: The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.Type: ApplicationFiled: July 26, 2004Publication date: December 30, 2004Applicant: INSITE VISION INCORPORATEDInventors: Chandler R. Dawson, Lyle M. Bowman
-
Patent number: 6699492Abstract: The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.Type: GrantFiled: April 22, 2002Date of Patent: March 2, 2004Assignees: InSite Vision Incorporated, SSP Co., Ltd.Inventors: Samir Roy, Santosh Kumar Chandrasekaran, Katsumi Imamori, Takemitsu Asaoka, Akihiro Shibata, Masami Takahashi, Lyle M. Bowman
-
Patent number: 6685958Abstract: The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.Type: GrantFiled: April 25, 2001Date of Patent: February 3, 2004Assignees: InSite Vision Incorporated, SSP Co., Ltd.Inventors: Samir Roy, Santosh Kumar Chandrasekaran, Katsumi Imamori, Takemitsu Asaoka, Akihiro Shibata, Masami Takahashi, Lyle M. Bowman
-
Publication number: 20030206956Abstract: The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.Type: ApplicationFiled: April 7, 2003Publication date: November 6, 2003Applicant: INSITE VISION INCORPORATEDInventors: Chandler R. Dawson, Lyle M. Bowman
-
Patent number: 6397849Abstract: Intrascleral injection of a therapeutic or diagnostic material at a location overlying the retina provides a minimally invasive technique for delivering the agent to the posterior segment of the eye. The procedure also allows for close proximity of the material to the targeted site and can be effectively used to treat conditions associated with the posterior segment of the eye, including macular degeneration, vein occlusion, and diabetic retinopathy. The sclera can be used to hold a depot of the material such as for sustained released or as a conduit for propelling material through whereby the material is delivered immediately to the underlying tissues but without physically penetrating the sclera with an instrument or otherwise unreasonably traumatizing the eye.Type: GrantFiled: August 2, 1999Date of Patent: June 4, 2002Assignee: InSite Vision IncorporatedInventors: Lyle M. Bowman, James F. Pfeiffer, Leslie A. Clark, Karl I. Hecker
-
Patent number: 6378526Abstract: Intrascleral injection of a therapeutic or diagnostic material at a location overlying the retina provides a minimally invasive technique for delivering the agent to the posterior segment of the eye. The procedure also allows for close proximity of the material to the targeted site and can be effectively used to treat conditions associated with the posterior segment of the eye, including macular degeneration, vein occlusion, and diabetic retinopathy.Type: GrantFiled: August 3, 1998Date of Patent: April 30, 2002Assignee: InSite Vision, IncorporatedInventors: Lyle M. Bowman, James F. Pfeiffer, Leslie A. Clark, Karl L. Hecker
-
Patent number: D603525Type: GrantFiled: October 10, 2008Date of Patent: November 3, 2009Assignees: Insite Vision Incorporated, Catalent Pharma SolutionsInventors: James Foreman, David Mufson, Roy Duane Archibald, Randal R. Schettl