Patents Assigned to Insitut National de la Sante et de la Recherche Medicale (INSERM)
  • Specific interleukin-15 (IL-15) antagonist polypeptide and uses thereof for the treatment of inflammatory and auto-immune diseases
    Patent number: 10858452
    Abstract: The present invention relates to specific interleukin-15 (IL-15) antagonist polypeptides and uses thereof for the treatment of inflammatory and auto-immune diseases. In particular, the present invention relates to a specific interleukin-15 (IL-15) antagonist polypeptide comprising i) a IL15-Ralpha sushi-containing polypeptide comprising an amino acid sequence having at least 80% of identity with the amino acid sequence of SEQ ID NO:1 ii) a linker and iii) an IL-polypeptide comprising the amino acid sequence having at least at least 80% of identity with the amino acid sequence of SEQ ID NO:4 provided that the glutamine (Q) residue at position 108 is mutated.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: December 8, 2020
    Assignees: Insitut National de la Sante et de la Recherche Medicale (INSERM), Universite de Nantes, Universite d'Angers, Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Nantes
    Inventors: Erwan Mortier, Dihia Meghnem, Sebastien Morisseau, Yannick Jacques
  • Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-deltaC virus) in cancer therapy
    Patent number: 9889193
    Abstract: The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumor or cancer conditions, and for the preparation of agents or compositions for such treatment.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: February 13, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCENTIFIQUE (CNRS), INSITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR, UNIVERSITE DE NANTES
    Inventors: Frédéric Tangy, Marc Gregoire, Jean-François Fonteneau, Jean-Baptiste Guillerme, Chantal Combredet
  • Detection of platelet-derived shed CD31
    Patent number: 9534036
    Abstract: The present invention relates to various soluble forms of CD31, including a novel form which is shed by activated platelets and released into the circulation. Methods for detecting said soluble forms of CD31 are disclosed, as are methods of specifically 1 detecting said platelet-derived shed CD31 and the use of such methods as a diagnostic tool.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 3, 2017
    Assignees: Insitut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris Diderot—Paris 7, Universite Paris 13—Paris Nord, Assistance Publique—Hopitaux de Paris
    Inventors: Giuseppina Caligiuri, Antonino Nicoletti
  • Anti-CD28 humanized antibodies
    Patent number: 8785604
    Abstract: The invention relates to humanized antibodies directed against the human lymphocyte receptor CD28. When used in a monovalent form these antibodies are antagonists, i.e. capable of blocking of the CD28/B7 interaction, without activating CD28. These antibodies can be used in particular as therapeutic agents for blocking T cell activation through the CD28 receptor.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: July 22, 2014
    Assignees: Effimune, Insitut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Caroline Mary, Nicolas Poirier, Bernard Vanhove
  • Methods for Selecting Oocytes and Competent Embryos with High Potential for Pregnancy Outcome
    Publication number: 20140148363
    Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo.
    Type: Application
    Filed: January 30, 2014
    Publication date: May 29, 2014
    Applicant: Insitut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Samir Hamamah, John De Vos, Said Assou