Patents Assigned to Insmed Pharmaceuticals, Inc.
  • Use of D-chiro-inositol in the treatment of conditions associated with hypothalamic gene expression
    Publication number: 20020032177
    Abstract: The present invention relates to the use of D-chiro-inositol (DCI) as a regulator of hypothalamic gene expression and, more particularly, to the use of DCI and derivatives and metabolites thereof to treat neuroendocrine impairments such as obesity, polycystic ovarian syndrome (PCOS), impaired regulation of hormones during aging and to correct such neuroendocrine impairments and associated functions.
    Type: Application
    Filed: April 30, 2001
    Publication date: March 14, 2002
    Applicant: Insmed Pharmaceuticals, Inc.
    Inventors: Geoffrey Allan, Charles V. Mobbs
  • Methods for the production and isolation of D-chiro-inositol from kasugamycin and the use of D-chiro-inositol obtained therefrom
    Patent number: 6342645
    Abstract: The present invention relates to methods for the production and isolation of D-chiro-inositol (DCI) from kasugamycin. More specifically, the present invention relates to a method of producing DCI by hydrolysis of kasugamycin with aqueous trifluoroacetic acid in the presence of a strongly acidic ion exchange resin. The present invention further relates to methods of isolating DCI from an aqueous mixture, such as a hydrolysis mixture, either directly or by forming an organic derivative of DCI.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: January 29, 2002
    Assignee: Insmed Pharmaceuticals, Inc.
    Inventors: Robert Plourde, Jr., Mark C. Sleevi, Rachel K. Longo
  • COMPOSITIONS AND METHOD FOR IMPROVING INSULIN SENSIVITY AND GLUCOSE METABOLISM IN INDIVIDUALS WITH IMPAIRED FASTING GLUCOSE OR IMPAIRED GLUCOSE TOLERANCE
    Publication number: 20010039297
    Abstract: The current invention relates to the use of D-chiro-inositol in improving insulin sensitivity and glucose metabolism in individuals with abnormal glucose tolerance who do not have Type 2 diabetes. D-chiro-inositol and related oral compositions may be used in treating abnormal glucose tolerance and metabolism and insulin sensitivity in mammals, and thus help prevent the progression to insulin-resistant Type 2 diabetes.
    Type: Application
    Filed: May 19, 1998
    Publication date: November 8, 2001
    Applicant: Insmed Pharmaceuticals, Inc.
    Inventor: GEOFFREY ALLAN
  • Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility
    Patent number: 5906979
    Abstract: This invention relates to compositions and methods for decreasing the level of serum insulin, triglycerides, cholesterol, and/or free and total testosterone, and/or improving ovulation, and/or increasing progesterone and/or sex hormone binding globulin in mammals. This invention also relates to compositions and methods for treating metabolic diseases characterized by hyperinsulinemia, hyperandrogenism, hyperlipidemia and/or anovulation, such as polycystic ovary syndrome.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: May 25, 1999
    Assignee: Insmed Pharmaceuticals, Inc.
    Inventor: Geoffrey Allan
  • Method for the production of D-chiroinositol
    Patent number: 5516950
    Abstract: The present invention relates to the synthesis of D-chiroinositol from a dialdose, comprising the steps of condensing the dialdose by an acyloin condensation reaction to form an inosose, protecting the carbon atoms at the 2, 3, 4 and 5 positions, reducing the ketone of the inosose and removing the protecting groups. In addition, a method of preparing mannodialdose from mannuronic acid is disclosed.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: May 14, 1996
    Assignee: Insmed Pharmaceuticals, Inc.
    Inventors: Thomas Piccariello, Gamini Samanaryke