Abstract: A method of generating a cellular model of Alzheimer's disease (AD) comprises integrating AD related gene to hiPSC to induce increased beta secretase and/or Abeta 42 peptides, and the cellular model of Alzheimer's disease (AD) is prepared by the method.

Abstract: An apparatus includes an implantable stimulator to treat sleep disordered breathing (SDB) and at least one electrode associated with the stimulator.

Abstract: Examples are directed to methods, devices, systems, computer-readable storage medium. An example non-transitory computer-readable storage medium comprises instructions that when executed cause a processing resource to present a graphical user interface (GUI) associated with a clinician portal, the GUI including a plurality of GUI portions that are individually and selectively displayable to present patient data for a plurality of patients based on at least one filter for different classes of the plurality of patients.

Abstract: An electrode cuff includes a first elongate portion and a second elongate portion. The first elongate portion is configured to removably contact a length of a nerve while the second elongate portion extends outwardly at an angle relative to a first side edge of the first elongate portion to at least partially wrap about the nerve. The electrode cuff includes a first series of electrodes that is spaced apart longitudinally along the first elongate portion. A width of the second elongate portion is sized to fit between adjacent branches extending from a nerve.

Abstract: A device for treating sleep disordered breathing includes a stimulation element to stimulate an airway-patency-related nerve.

Abstract: A system and method for treating sleep apnea includes inserting an implantable pulse generator subcutaneously within a body of a patient and connecting a lead to the pulse generator. The lead is inserted within the vasculature and advanced transvenously through the vasculature until a stimulation portion of the lead becomes positioned in close proximity to the hypoglossal nerve. A nerve-stimulation signal is applied to the hypoglossal nerve via the stimulation portion of the lead.

Abstract: Solder reflowing a feedthrough pin to internal electronics of an electronic device and interface block constructions conducive to solder reflow.

Abstract: Provided are stellate compounds that target spike proteins and have a significant anti-SARS-CoV-2 ability and a certain broad spectrum. Such molecules and salts thereof have at least one basic unit R(X)n, which binds at an orthotopic binding site such as an MD domain or an allosteric site, to a virus containing spike proteins or a virus having spike proteins on its surface, thereby preventing coronavirus or other viruses which express spike proteins on their surfaces from invading host cells, and preventing the occurrence of viral infection. In addition, interaction of the molecules and salts thereof with vitamin K-dependent proteins in the human body inhibits the expression of vitamin K so as to inhibit blood coagulation in the human body, thereby treating thrombosis caused by coronavirus and producing a curative effect for pneumonia caused by a severe viral infection.

Abstract: A method comprises establishing communication between a therapy device implantable in a patient and a consumer electronic device operable by the patient. The method comprises controlling, by the consumer electronic device, a predetermined set of therapy device functions in response to patient inputs to the consumer electronic device. The method also comprises transmitting therapy data from the therapy device to the consumer electronic device. The method further comprises presenting therapy data on a display of the consumer electronic device.

Abstract: An apparatus includes an implantable stimulator to treat sleep disordered breathing (SDB) and at least one electrode associated with the stimulator. The apparatus includes a therapy device arranged to be implanted within a head/neck region of a patient. The therapy device includes a microstimulator including a housing to encapsulate at least stimulation circuitry, a rechargeable power element, and a control portion including a therapy manager to control the stimulation circuitry.

Abstract: Methods and/or devices to identify disease burden indication are disclosed. One type of disease comprises sleep disordered breathing and/or related parameters, which may be sensed via implantable sensors such as an acceleration sensor.

Abstract: A system and/or method to control operation of an implantable medical device in response to sensed posture information.

Abstract: A dermal skin protectant and carrier comprising a combination of two different viscosity dimethicone components, wherein the difference between the two different viscosity dimethicone components is about 2.0 million cP or greater; and comprising at least one active ingredient.

Abstract: An output signal driver includes a positive output node, a negative output node, a power supply input node, a power supply common node, a charging capacitor, a discharging capacitor, a current source, a current sink, a first switch, a second switch, and a controller. The charging capacitor is coupled to the power supply input node. The discharging capacitor is coupled to the negative output node. The current source is coupled between the power supply input node and the positive output node. The current sink is coupled between the positive output node and the power supply common node. The first switch is coupled in parallel with the current source. The second switch is coupled in parallel with the current sink. The controller is coupled to the current source, the current sink, the first switch, and the second switch to apply either complementary constant current pulses or complementary constant voltage pulses to the positive output node.

Abstract: A method of using a self-adjusting stent assembly includes estimating body lumen diameter(s) associated with a portion of a body lumen in which a stent assembly will be placed; determining, based on the estimated diameter(s), target expanded stent diameter(s) of the stent assembly which is to be placed in the portion of the body lumen; selecting the stent assembly for stenting the portion of the body lumen, wherein the stent assembly is configured to: expand from an initial to expanded diameters within a range of expanded diameters; wherein the range of expanded diameters is from about 9 mm to about 5.5 mm; and wherein the target expanded stent diameter(s) is/are within the range of expanded diameters; and apply a chronic radial force to a wall that forms the portion of the lumen, wherein the radial force is less than about 0.33 N/mm; and implanting the stent assembly in the portion of the body lumen.

Abstract: Devices and/or methods for treating sleep disordered breathing may include stimulation of a single nerve, multiple nerves, as well as other tissues relating to upper airway patency.

Abstract: A device includes a sensor signal input node and a high-pass filter stage. The high-pass filter stage includes an operational amplifier and a feedback integrator. The operational amplifier includes an input node coupled to the sensor signal input node. The feedback integrator is coupled between an output node of the operational amplifier and the input node of the operational amplifier to set a high-pass pole frequency of the high-pass filter stage.