Abstract: Tunable monolithic cavity-based frequency converter pumped by a single-frequency laser where cavity resonance(s) are achieved by independently changing the temperatures of different sections of the crystal, including the periodically poled section and one or more adjacent, non-poled regions. Having independent control of the phase matching temperature and the cavity resonance for a down-converted beam increases the efficiency.
Type:
Grant
Filed:
September 21, 2017
Date of Patent:
June 26, 2018
Assignees:
FUNDACIO INSTITUT DE CIENCIES FOTONIQUES, INSTITUCIO CATALANA DE RECERCA I ESTUDIOS AVANCATS
Inventors:
Joanna A. Zielinska, Morgan W. Mitchell
Abstract: The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a large set of effector functions. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen.
Type:
Grant
Filed:
March 22, 2013
Date of Patent:
July 18, 2017
Assignees:
LABORATORIOS DEL DR. ESTEVE S.A., FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIOS AVANÇATS
Inventors:
Marta Ruiz Riol, Christian Brander, Javier Ibarrondo