Patents Assigned to INSTITUT CLAUDIUS REGAUD
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Patent number: 11319381Abstract: The present invention relates to active form specific anti-Rho GTPase conformational single domain antibodies and their uses in particular in the therapeutic and diagnostic fields. In particular, the present invention relates to a single domain antibody wherein the amino acid sequences of CDR1-IMGT, CDR2-IMGT and CDR3-IMGT have at least 90% of identity with the amino acid sequences of the CDR1-IMGT, CDR2-IMGT and CDR3-IMGT of the H12, B6, 4P75, 4SP1, 4SNP36, 4SNP61, 5SP10, 5SP11, 5SP58, 5SNP47, 5SNP48, 5SNP65, B20, B15, B5, B71, E3, A6, G12, NB61, 212B, 111B or 404F (hs2dAb) single domain antibody which are defined in Table B.Type: GrantFiled: December 4, 2019Date of Patent: May 3, 2022Assignees: INSERM (Institut National de la Santéet de la Recherche Médicale), UniversitéPaul Sabatier Toulouse III, Institut Claudius RegaudInventors: Aurelien Olichon, Laura Keller, Gilles Favre, Nicolas Bery, Patrick Chinestra
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Patent number: 11186634Abstract: The present invention relates to antibodies targeting Tumor Associated Macrophages (TAMs) and uses thereof. The inventors investigated specific marker exposed on the surface of the macrophages associated to tumor in order to detect and target TAMs. They showed that sideroflexin 3, which is absent in normal macrophage, is expressed by tumor associated macrophages. The inventors further demonstrated that using antibody directed to sideroflexin 3, they depleted TAMs in PBMC sample obtained from LCC patient, and strongly reduced leukemic B cells number.Type: GrantFiled: July 28, 2017Date of Patent: November 30, 2021Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paul Sabatier Toulouse, Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse, Institut Claudius RegaudInventors: Mary Poupot, Loïc Ysebaert, Marie Tosolini, Jean-Jacques Fournie, Pierre Brousset, Philippe Rochaix
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Patent number: 10544210Abstract: The present invention relates to active form specific anti-Rho GTPase conformational single domain antibodies and their uses in particular in the therapeutic and diagnostic fields. In particular, the present invention relates to a single domain antibody wherein the amino acid sequences of CDR1-IMGT, CDR2-IMGT and CDR3-IMGT have at least 90% of identity with the amino acid sequences of the CDR1-IMGT, CDR2-IMGT and CDR3-IMGT of the H12, B6, 4P75, 4SP1, 4SNP36, 4SNP61, 5SP10, 5SP11, 5SP58, 5SNP47, 5SNP48, 5SNP65, B20, B15, B5, B71, E3, A6, G12, NB61, 212B, 111B or 404F (hs2dAb) single domain antibody which are defined in Table B.Type: GrantFiled: February 2, 2016Date of Patent: January 28, 2020Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paul Sabatier, Institut Claudius RegaudInventors: Aurelien Olichon, Laura Keller, Gilles Favre, Nicolas Bery, Patrick Chinestra
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Patent number: 10144772Abstract: The present invention relates to a TNF? blocking agent for use in the treatment and prevention of melanoma in a subject in whom melanoma cells express MHCI and in whom stroma cells exhibit TNF expression.Type: GrantFiled: May 12, 2015Date of Patent: December 4, 2018Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre Hospitalier Universitaire de Toulouse, Institut Claudius Regaud, Universite Paul Sabatier Toulouse IIIInventors: Bruno Segui, Nathalie Andrieu-Abadie, Thierry Levade, Celine Colacios Viatge, Philippe Rochaix, Florie Bertrand, Herve Benoist, Julia Rochotte
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Patent number: 8865408Abstract: The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in the patient cancer sample, calculating an expression level ratio of the expression level of POLQ to the expression of the control gene in the patient cancer sample, comparing the expression level ratio to a corresponding threshold value, and diagnosing cancer aggressiveness and genetic instability if the POLQ expression level ratio is superior to a corresponding threshold value. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.Type: GrantFiled: May 18, 2011Date of Patent: October 21, 2014Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paul Sabatier Toulouse III, Institut Claudius RegaudInventors: Christophe Cazaux, Jean-Sébastien Hoffmann, Jean-Christophe Bourdon, Alice Machado Da Silva, Henri Roche
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Publication number: 20120021935Abstract: The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.Type: ApplicationFiled: May 18, 2011Publication date: January 26, 2012Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT CLAUDIUS REGAUD, UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Christophe CAZAUX, Jean-Sébastien HOFFMANN, Jean-Christophe BOURDON, Alice MACHADO DA SILVA, Henri ROCHE
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Publication number: 20070072167Abstract: The invention relates to a tissue binding composition. The inventive composition is characterised in that it comprises: between 40 g/l and 80 g/l trehalose, preferably approximately 60 g/l; between 40% and 80% (v/v) ethanol, preferably approximately 70% (v/v): between 0% and 5% (v/v) acetic acid, preferably approximately 1% (v/v); and between 20% and 60% (v/v) water, preferably approximately 29% (v/v).Type: ApplicationFiled: March 12, 2004Publication date: March 29, 2007Applicant: INSTITUT CLAUDIUS REGAUDInventor: Philippe Rochaix