Patents Assigned to Institut de Radioprotection et de Surete Nucleaire
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Patent number: 10677936Abstract: The device (10) comprises a first detector (16) for a measurement on a thyroid and a second detector (18) for a measurement on a thorax. It comprises a portable device (14) for supporting detectors, comprising: a transverse support crossmember (20), —at least one support leg (22) carrying said support cross-member (20), and —a support member (28), borne by the crossmember (20), including first (28A) and second (28B) portions movable relative to one another in a longitudinal direction (X), the first movable portion (28A) bearing the first detector (16), and the second movable portion (28B) bearing the second detector (18).Type: GrantFiled: April 14, 2017Date of Patent: June 9, 2020Assignee: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventors: Alain Didier Franck, Roger Marcel Didier Viltard
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Patent number: 10624838Abstract: The present invention relates to the use of gingival fibroblast-derived products to reduce hair loss and promote hair growth. Specifically, the invention relates to a product derived from gingival fibroblasts to be used in the treatment or prevention of alopecia, as well as in the promotion of natural hair growth and/or in the control of natural hair loss.Type: GrantFiled: July 9, 2014Date of Patent: April 21, 2020Assignees: ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE, ETAT FRANCAIS—MINISTERE DE AL DEFENSE—DIRECTION CENTRALE DU SERVICE DE SANTE DES ARMEES, UNIVERSITE PARIS DESCARTESInventors: Antoine Lafont, Bernard Coulomb, Jean-Jacques Lataillade, Christine Linard
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Patent number: 10448918Abstract: The invention concerns a thyroid phantom (1), the phantom comprising a body (2) comprising at least two parts (3, 4) defining between them an imprint (7) of a thyroid and means for attaching the two parts together in order to close the imprint in a sealed manner, the phantom further comprising means for filling the imprint with a solution, said filling means comprising at least one channel (19, 20) extending from the outside of the body into the imprint and means for temporarily symmetrically plugging said channel. The invention also concerns a method for producing such a thyroid phantom, a family comprising a plurality of such thyroid phantoms corresponding to different categories of human beings, an overall phantom comprising one such thyroid phantom as well as a family comprising a plurality of overall phantoms.Type: GrantFiled: January 26, 2017Date of Patent: October 22, 2019Assignee: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventors: David Broggio, Tiffany Beaumont
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Patent number: 10234362Abstract: The invention relates to a collection device (10) that comprises a plurality of collection containers (12A, 12B, 12C) suitable for receiving rainwater, each collection container (12A. 12B, 12C) comprising a circumferential wall (14) and a lower wall (16). The collection containers (12A, 12B, 12C) are stacked so as to form a stack along a vertical axis (Z). Each container (12A, 12B) arranged above another, adjacent container (12B, 12C) comprises a water flow opening (18) that is provided in the lower wall (16) thereof and leads into said other, adjacent container (12B, 12C). Each container (12B, 12C) that is arranged below another, adjacent container (12A, 12B) houses a buoyant closure element (20) that is movable along the vertical axis (Z) between a lower position and an upper position depending on the amount of water in said container (12B, 12C) and closes the flow opening (18) in the upper position.Type: GrantFiled: August 18, 2015Date of Patent: March 19, 2019Assignee: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventors: Denis Maro, Philippe Laguionie
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Publication number: 20190029633Abstract: The invention concerns a thyroid phantom (1), the phantom comprising a body (2) comprising at least two parts (3, 4) defining between them an imprint (7) of a thyroid and means for attaching the two parts together in order to close the imprint in a sealed manner, the phantom further comprising means for filling the imprint with a solution, said filling means comprising at least one channel (19, 20) extending front the outside of the body into the imprint and means for temporarily symmetrically plugging said channel. The invention also concerns a method for producing such a thyroid phantom, a family comprising a plurality of such thyroid phantoms corresponding to different categories of human beings, an overall phantom comprising one such thyroid phantom as well as a family comprising a plurality of overall phantoms.Type: ApplicationFiled: January 26, 2017Publication date: January 31, 2019Applicant: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventors: David BROGGIO, Tiffany BEAUMONT
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Patent number: 10175333Abstract: The invention relates to a dosimeter comprising a quantity of dosimetric material, the dosimeter being suitable for being irradiated and undergoing a dose measurement by EPR spectroscopy, the enclosure being made from a material not having a response in EPR spectroscopy or having a response different from the response of the dosimetric material after identical irradiation such that the signal of the material of the enclosure decreases as a function of time after irradiation of said material such that a period of time exists after irradiation at the end of which the material has no measurable signal, or a residual signal whose intensity is less than 5% of that measured after irradiation, and the dosimetric material has a constant EPR signal alter irradiation. The invention also relates to a method for measuring the dose absorbed by the dosimetric material contained in such a dosimeter.Type: GrantFiled: July 9, 2014Date of Patent: January 8, 2019Assignees: Institut de Radioprotection et de Sûreté Nucléaire, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Tristan Garcia, François Trompier
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Patent number: 10031093Abstract: The invention relates to a radiation-induced radical species characterized in that it has, when measuring a biological nail, hair, or stratum corneum tissue sample by continuous wave EPR spectroscopy at ambient temperature: a Lande factor of 2.004; during Q band measurements at ambient temperature, a minimum signal intensity and a maximum signal intensity, said intensities being reached for magnetic field values separated by 1.8 mT; during X band measurements, a signal forming a singlet; and at the highest frequency, a signal having Lande factor anisotropy. The invention also relates to methods suitable for the identified radical species and intended for preparing a sample, analyzing the measured signal, and estimating a received dose.Type: GrantFiled: December 18, 2014Date of Patent: July 24, 2018Assignee: Institut de Radioprotection et de Sûreté NucléaireInventor: François Trompier
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Patent number: 9835506Abstract: The present invention relates to a method for estimating the thermophysical properties of a material (?) that incorporates at least one temperature sensor (1, 2, 3) and one point heat source (4), the distance between the at least one temperature sensor (1, 2, 3) and the point heat source (4) being known. The method includes the steps of: expression of the theoretical temperature as a function of time at the at least one temperature sensor (1, 2, 3) when the point heat source (4) is activated, said expression depending on the thermophysical parameters of the material (?); acquisition of a plurality of temperature measurements by the at least one temperature sensor (1, 2, 3) over a time period during which the point heat source (4) is activated; and determining of the values of the thermophysical parameters of the material (?), such that the difference between the theoretical temperatures obtained via said expression and the temperatures that are actually measured is minimal.Type: GrantFiled: December 20, 2012Date of Patent: December 5, 2017Assignees: Institut de Radioprotection et de Sûreté Nucléaire, Universite D'Aix-MarseilleInventors: Serge Pons, Mickaël Coutin, Sébastien Luciani, Christophe Le Niliot, Fabrice Rigollet
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Publication number: 20160370308Abstract: The invention relates to a radiation-induced radical species characterized in that it has, when measuring a biological nail, hair, or stratum corneum tissue sample by continuous wave EPR spectroscopy at ambient temperature: a Lande factor of 2.004; during Q band measurements at ambient temperature, a minimum signal intensity and a maximum signal intensity, said intensities being reached for magnetic field values separated by 1.8 mT; during X band measurements, a signal forming a singlet; and at the highest frequency, a signal having Lande factor anisotropy. The invention also relates to methods suitable for the identified radical species and intended for preparing a sample, analyzing the measured signal, and estimating a received dose.Type: ApplicationFiled: December 18, 2014Publication date: December 22, 2016Applicant: Institut de Radioprotection et de Sûreté NucléaireInventor: François Trompier
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Patent number: 9399270Abstract: The invention relates to an optimized laser cutting method for cutting a part from a material by means of a cutting system comprising: a laser source for producing a laser beam having a certain power; and a cutting head comprising an end nozzle for passage of a cutting laser beam, said method being characterized in that it comprises a step of determining the cutting power Pd such that: Pd=Max(Popt;?e) where Max is the mathematical operator of the maximum, Popt is an optimal power of the laser beam of the cutting system, which is predetermined in accordance with the part to be cut, and/or with cutting parameters and/or with system parameters, to minimize the mass defect per unit length of the part when the part is being cut, ? is a leading coefficient representing the number of kW required for cutting the part per mm of the thickness of the part, and e is the thickness of the part in mm.Type: GrantFiled: October 28, 2011Date of Patent: July 26, 2016Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, Institut de Radioprotection et de Sûreté NucléaireInventors: Christophe Chagnot, Gaëtan Canneau, Guy Pilot, Sylvain Fauvel
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Publication number: 20160146919Abstract: The invention relates to a dosimeter comprising a quantity of dosimetric material, the dosimeter being suitable for being irradiated and undergoing a dose measurement by EPR spectroscopy, the enclosure being made from a material not having a response in EPR spectroscopy or having a response different from the response of the dosimetric material after identical irradiation such that the signal of the material of the enclosure decreases as a function of time after irradiation of said material such that a period of time exists after irradiation at the end of which the material has no measurable signal, or a residual signal whose intensity is less than 5% of that measured after irradiation, and the dosimetric material has a constant EPR signal alter irradiation. The invention also relates to a method for measuring the dose absorbed by the dosimetric material contained in such a dosimeter.Type: ApplicationFiled: July 9, 2014Publication date: May 26, 2016Applicants: Institut de Radioprotection et de Sûreté Nucléaire, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Tristan Garcia, François Trompier
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Patent number: 9333592Abstract: The invention relates to an optimized laser cutting method for cutting a part from a material by means of a cutting system comprising: a laser source for producing a laser beam having a certain power; and a cutting head comprising an end nozzle for passage of a cutting laser beam, wherein the method comprises: determining a cutting power Pd such that Pd=Max(Popt;?e) where Max is the mathematical operator of the maximum, Popt is an optimal power of the laser beam of the cutting system, which is predetermined in accordance with the part to be cut, and/or with cutting parameters and/or with system parameters, in order to minimize the amount of aerosols produced when the part is cut, ? is a leading coefficient representing the number of kW required for cutting the part per mm of the thickness of the part, and e is the thickness of the part in mm.Type: GrantFiled: October 28, 2011Date of Patent: May 10, 2016Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, Institut de Radioprotection et de Sûreté NucléaireInventors: Christophe Chagnot, Gaétan Canneau, Guy Pilot, Sylvain Fauvel
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Publication number: 20150177408Abstract: The invention relates to a method for a study of a photon emission source at a site, the method including the steps consisting of: measuring (100) the spectrometric data and the geographic coordinates of the measurement point at a surface point of said site and storing said data in association with said coordinates in a memory; moving (200) the detector to at least one other point of the site and, at each point, repeating the step of measuring and storing; and implementing a deconvolution step (500), using a predetermined detector response function, on all the measured spectrometric surface data, in order to obtain refined spectrometric surface information, said spectrometric surface information enabling the geographic location and the evaluation of the photon emission rate of said source. The invention further relates to a system suitable for implementing the method.Type: ApplicationFiled: July 19, 2013Publication date: June 25, 2015Applicant: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventors: Fabien Panza, Rodolfo Gurrarian
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Patent number: 8987334Abstract: The invention relates to the use of calixarenes for preventing or limiting the transfer of an actinide in the body from a site of skin contamination.Type: GrantFiled: December 17, 2009Date of Patent: March 24, 2015Assignee: Institut de Radioprotection et de Surete NucleaireInventors: Aurélie Spagnul, François Rebiere, Guillaume Phan, Céline Bouvier-Capely, Elias Fattal
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Patent number: 8866472Abstract: A device for detection of at least one defect in a concave or convex structure including an emitting part and a receiving part, in which the emitting part includes at least one current layer that makes it possible to create currents oriented approximately along a same direction as the defects whose influence is to be minimized and the receiving part includes at least one magnetic field receiver, added on or etched on a flexible support.Type: GrantFiled: July 28, 2010Date of Patent: October 21, 2014Assignees: Commissariat à l' énergie Atomique et aux énergies Alternatives, Institut de Radioprotection et de Surete NucleaireInventors: Jean-Marc Decitre, Olivier Casula, Gerard Cattiaux
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Publication number: 20140054274Abstract: The invention relates to an optimized laser cutting method for cutting a part from a material by means of a cutting system comprising: a laser source for producing a laser beam having a certain power; and a cutting head comprising an end nozzle for passage of a cutting laser beam, wherein the method comprises: determining a cutting power Pd such that Pd=Max(Popt;?e) where Max is the mathematical operator of the maximum, Popt is an optimal power of the laser beam of the cutting system, which is predetermined in accordance with the part to be cut, and/or with cutting parameters and/or with system parameters, in order to minimize the amount of aerosols produced when the part is cut, ? is a leading coefficient representing the number of kW required for cutting the part per mm of the thickness of the part, and e is the thickness of the part in mm.Type: ApplicationFiled: October 28, 2011Publication date: February 27, 2014Applicants: Institut de Radioprotection et de Sûreté Nucléaire, Commissariat À L' Energie Atomique et aux Energies AlternativesInventors: Christophe Chagnot, Gaétan Canneau, Guy Pilot, Sylvain Fauvel
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Publication number: 20140044721Abstract: The present invention lies in the field of new cancer therapies, more precisely in the field of antiangiogenic compounds. It notably concerns anti-Gb3 antibodies having specific CDR sequences, as well as the use of anti-Gb3 antibodies not coupled to a therapeutic molecule in the treatment of diseases associated with angiogenesis, such as solid tumors.Type: ApplicationFiled: February 7, 2012Publication date: February 13, 2014Applicants: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE, UNIVERSITE DE NANTESInventors: François Paris, Stephane Birkle, Ariane Desselle, Jacques Aubry, Marie-Hélène Gaugler, Denis Cochonneau, Tanguy Chaumette
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Publication number: 20130299473Abstract: The invention relates to an optimized laser cutting method for cutting a part from a material by means of a cutting system comprising: a laser source for producing a laser beam having a certain power; and a cutting head comprising an end nozzle for passage of a cutting laser beam, said method being characterized in that it comprises a step of determining the cutting power Pd such that: Pd=Max(Popt;?e) where Max is the mathematical operator of the maximum, Popt is an optimal power of the laser beam of the cutting system, which is predetermined in accordance with the part to be cut, and/or with cutting parameters and/or with system parameters, to minimize the mass defect per unit length of the part when the part is being cut, ? is a leading coefficient representing the number of kW required for cutting the part per mm of the thickness of the part, and e is the thickness of the part in mm.Type: ApplicationFiled: October 28, 2011Publication date: November 14, 2013Applicants: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventors: Christophe Chagnot, Gaëtan Canneau
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Patent number: 8212204Abstract: A calibrated radioactive source comprises a container and a material labelled by at least one radionuclide. The labelled material is contained in the container and the container is made of a material that is transparent to the radiation emitted by the at least one radionuclide. The source is characterized in that the labelled material is a self-hardening polymer that is chemically inert relative to the material used for the container and in that the container is a flexible sheath. The calibrated source is placed into a hole of a brick of a tissue-equivalent phantom. An assembly is formed by such a calibrated source and a brick of tissue-equivalent phantom.Type: GrantFiled: December 4, 2008Date of Patent: July 3, 2012Assignee: Institut de Radioprotection et de Surete NucleaireInventor: Alain Maulard
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Patent number: D753516Type: GrantFiled: August 6, 2014Date of Patent: April 12, 2016Assignee: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventor: Mathieu Le Gall