Patents Assigned to Institut de Recherches Chimiques et Biologiques Appliquees
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Patent number: 5322846Abstract: The present invention relates to novel 4-methylthiazole derivatives, to tr methods of preparation and to the pharmaceutical compositions in which they are present.According to the invention, these derivatives have the general formula ##STR1## in which n is equal to 0 or 1 and R.sub.1 and R.sub.2, which are identical or different, are selected from a hydrogen atom, a halogen, a hydroxyl group, a trifluoromethyl group, an alkyl group having from 1 to 4 carbon atoms and an alkoxy group having from 1 to 5 carbon atoms and are useful in the treatment of cardiovascular diseases associated with hyperactivity of the sympathetic nervous system.Type: GrantFiled: October 19, 1992Date of Patent: June 21, 1994Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)Inventors: Fabienne Jobard-Rouppert, Patrick Houziaux, Jean-Pierre Riffaud, Jean-Yves Lacolle, Patrick Saur, Bernard Danree
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Patent number: 5212161Abstract: The present invention relates to novel derivatives of 2'-deoxyuridine substituted in the 5-, 3'- or 5'-position by .alpha.-aminoacyl groups, to a process for their preparation and the drugs in which they are present.These derivatives have the following general formula: ##STR1## in which R is selected from an alkyl or alkenyl radical having from 1 to 4 carbon atoms, an aryl radical or a halogen, it being possible for said alkyl, alkenyl and aryl radicals to contain at least one halogen substituent, and a radical of the formula --NH--R.sub.1, in which R.sub.1 is an amino acid residue or a peptide residue containing from 2 to 6 amino acids; andR' and R" are selected from a hydroxyl radical and a radical of the formula --NH--R.sub.1, in which R.sub.1 is as defined above,with the proviso that R' and R" are not simultaneously --NH--R.sub.1 and that, when R is --NH--R.sub.1, R' and R" are simultaneously a hydroxyl group.Application: treatment of cancers and viral infections.Type: GrantFiled: August 17, 1990Date of Patent: May 18, 1993Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)Inventors: Jean-Luc Moriniere, Michelle Faulques, Claude Rousseau, Bernard Danree, Claude Marquer, Patrick Saur, Jean Lemoine, Jean-Yves Lacolle
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Patent number: 5120736Abstract: The present invention relates to novel 4-methyl-5-[2-(4-phenylpiperazin-1-yl)ethyl]thiazole derivatives of the general formula ##STR1## in which R is selected from a hydrogen atom, an alkyl radical having from 2 to 7 carbon atoms and an aralkyl radical of which the aryl moiety preferably consists of phenyl and of which the alkyl moiety has from 1 to 4 carbon atoms, and to the pharmaceutically acceptable salts of these derivatives.It further relates to a method of preparing these products and to pharmaceutical compositions in which they are incorporated.These derivatives are applied especially in the preparation of drugs intended for the treatment of functional dysuria associated with hyperactivity of the .alpha.-adrenergic sympathetic nervous system.Type: GrantFiled: April 11, 1991Date of Patent: June 9, 1992Assignee: Institut de Recherches Chimiques et Biologiques AppliqueesInventors: Patrick Houziaux, Jean-Pierre Riffaud, Jean-Yves LaColle, Bernard Danree
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Patent number: 5110816Abstract: The present invention relates to the products of general formula (I): ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are selected om a hydrogen atom, a halogen atom, a hydroxyl radical, an alkyl radical having from 1 to 5 (sic) carbon atoms, an alkoxy radical having from 1 to 5 carbon atoms or a phenoxy, benzyloxy, trifluoromethyl or acetyl radical.It further relates toa method of preparing said productsand the drugs in which said products are present.Type: GrantFiled: December 12, 1990Date of Patent: May 5, 1992Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)Inventors: Patrick Houziaux, Jean-Pierre Riffaud, Jean-Yves Lacolle, Bernard Danree
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Patent number: 4880807Abstract: The present invention relates, by way of novel industrial products, to(i) 4-aryl-1-nicotinoylpiperazines of the formula ##STR1## in which R.sub.1 and R.sub.2, which can be identical or different, each represent the hydrogen atom, a halogen atom (especially F, Cl or Br) or a CF.sub.3, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.2 -C.sub.4 -acyl group; and(ii) addition salts thereof.These products are useful in therapy as anticonvulsants.Type: GrantFiled: December 7, 1988Date of Patent: November 14, 1989Assignee: Institut De Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)Inventors: Bernard Danree, Michelle Faulques, Jean-Yves Lacolle, Jean-Pierre Riffaud
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Patent number: 4795758Abstract: The present invention relates to novel products of the formula: ##STR1## in which R is selected from the group comprising H, OH, --O--COCH.sub.3 and --O--CO--(CH.sub.2).sub.n --CH.sub.3, in which n is between 1 and 8, and the salts of the products of the formula (I) with pharmaceutically acceptable acids.Type: GrantFiled: May 15, 1987Date of Patent: January 3, 1989Assignee: Societe a Responsabilite Limitee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)Inventors: Bernard Danree, Patrick Houziaux, Jean-Yves Lacolle
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Patent number: 4659741Abstract: This invention is concerned with new .beta.-[2-(halogenobenzyl)-phenoxy]-ylamine derivatives of the general formula ##STR1## wherein R represents a C.sub.1 -C.sub.8 -alkyl group having a linear or branched hydrocarbon chain,R.sub.1 and R.sub.2, which may identical or different, represent each a C.sub.1 -C.sub.4 -alkyl-group, andAr represents a polychlorophenyl group of the formula ##STR2## (in which Y.sub.1 is 4-Cl, Y.sub.2 is H or Cl, and Y.sub.3 is H or Cl, at least one of the Y.sub.2 and Y.sub.3 being Cl); and their addition salts.These new compounds are useful as pharmaceuticals.Type: GrantFiled: November 27, 1984Date of Patent: April 21, 1987Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A)Inventors: Jean-Yves Lacolle, Bernard Danree
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Patent number: 4186211Abstract: This invention is concerned with a therapeutic composition intended in particular for the treatment of secretory disorders of the prostate gland, containing a pharmaceutically active quantity of at least one higher alkanol with 16 or more carbon atoms or one of its esters in association with a physiologically acceptable vehicle.Type: GrantFiled: August 30, 1974Date of Patent: January 29, 1980Assignee: Societe Dite: Institut de Recherches Chimiques et Biologiques Appliquees-I.R.C.E.B.A.Inventor: Jacques Debat
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Patent number: 4151278Abstract: The present invention relates to a process for the preparation of an extract of Teucrium marum used in therapy, according to which the whole plant, or part of the plant, is subjected to a treatment with a solvent, the said process being characterized in that the said treatment is carried out with a solvent chosen from among the group comprising boiling water in the presence of NH.sub.3, pentane, hexane, heptane, cyclohexane, cyclopentane, petroleum ether, methylene chloride and mixtures of these, and in that, if necessary, the resulting extract is subjected to a purification.Type: GrantFiled: October 14, 1977Date of Patent: April 24, 1979Assignee: Institut de Recherches Chimiques et Biologiques AppliqueesInventors: Jacques Debat, Jean Lemoine, Bernard Guay, Claude Crescioni
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Patent number: 4113875Abstract: The invention relates to novel compounds in the form of epoxy alkanes corresponding to the formula ##STR1## in which B is H or CH.sub.3 and A represents a hydrocarbon radical containing at least 15 carbon atoms.These epoxy alkanes are suitable for therapeutic application, especially in the treatment of secretory disorders of the prostate gland, more especially prostate adenoma.Type: GrantFiled: April 5, 1976Date of Patent: September 12, 1978Assignee: Institut de Recherches Chimiques et Biologiques AppliqueesInventor: Jacques Debat
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Patent number: 3984482Abstract: The specification describes novel 2-(4'-halobenzyl) phenols of the formula: ##SPC1##In which R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, re hydrogen or a lower alkyl group, provided that only one of R.sub.1 , R.sub.2 and R.sub.3 is hydrogen, or any two or R.sub.1, R.sub.2 and R.sub.3 form, together with the carbon atom to which they are attached, a cycloalkyl ring, particularly cyclohexyl, and the third substituent is hydrogen; R.sub.4 is hydrogen, halogen, a nitro group or a benzyl group, the latter, if desired, being substituted in the same manner as the benzyl group shown in the ortho position of the phenolic nucleus; R.sub.5 is hydrogen or a hydroxyl group; X is halogen, particularly chlorine or bromine, and Y is hydrogen or halogen, particularly chlorine or bromine, and a process for their preparation. These compounds have useful bacteriostatic activity.Type: GrantFiled: September 25, 1974Date of Patent: October 5, 1976Assignee: Institut de Recherches Chimiques et Biologiques Appliquees I.R.C.E.B.A.Inventor: Jacques Debat