Abstract: The invention relates to the use of peptidic conjugates containing Gly-His-Lys for producing dermatological or cosmetological compositions for stimulating hair growth or stopping hair fall.
Type:
Grant
Filed:
July 16, 2004
Date of Patent:
March 24, 2009
Assignee:
Institut European De Biologie Cellulaire
Abstract: The invention relates to peptides of formula (I) R-V1-Ala2-His3-X4-Y5-Trp5-NH2 wherein R represents a hydrogen atom or a protective group which can be chosen from among a benzoyl group, a tosyl group, a benzene sulfonyl group, a benzyloxycarbonyl group or a pyridinepropionyl group; V represents a natural amino acid or not chosen from among norleucine, norvaline and 2-N-Me-norleucine, X represents a natural amino acid or not having an aromatic character chosen from among phenylalanine, 1-naphtylalanine, 2-naphtylalanine, phenylglycine, benzothienylalanine, 4,4?-biphenylalanine, 3,3-diphenylalanine, homophenylalanine, indanylglycine, 4-methylphenylalanine, thienylalanine, p-nitrophenylalanine, halogenophenylalanine of configuration L or D; Y represents a natural amino acid of configuration L, having a basic character chosen from among arginine, lysine or ornithine, the enantiometers or diastercoisomers, and the mixtures thereof, including racemic mixtures.
Type:
Grant
Filed:
January 31, 2003
Date of Patent:
September 11, 2007
Assignee:
Institut European de Biologie Cellulaire
Abstract: The invention relates to peptide conjugates comprising a sequence of at least 3 amino acids derived from a thymic hormone selected amongst thymuline and thymopoietine, the amino acids being independently in the form D, L or DL, said sequence being chemically or physically conjugated with at least one compound selected amongst monocarboxylic acids having the general formula (I): HOOC—R, as well as alcohol, aldehyde or amide derivatives, the dicarboxylic acids having the general formula (II): HOOC—R1—COOH. The invention also relates to the use of such conjugates as medicaments, and pharmaceutical or cosmetological compositions containing them.
Type:
Grant
Filed:
August 24, 1998
Date of Patent:
April 3, 2001
Assignee:
Institut European de Biologie Cellulaire