Patents Assigned to Institut Farmaceutyczny
  • Methods for preparation of olanzapine polymorphic form I
    Patent number: 7538213
    Abstract: The invention relates to the methods for preparation of olanzapine polymorphic Form I. The invention also provides new mixed solvates of olanzapine, which are valuable intermediates used in the preparation of pure olanzapine polymorphic Form I.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: May 26, 2009
    Assignee: Institut Farmaceutyczny
    Inventors: Janina Piechaczek, Magdalena Glice, Urszula Fraczek, Jadwiga Serafin, Wieslaw Szelejewski, Krzysztof Soltysiak
  • Process and intermediates to prepare17beta-hydroxy-7alpha-methyl-19-nor-17alpha-pregn -5(10)-en-20-yn-3-one
    Publication number: 20060111332
    Abstract: The present invention is a process for the preparation of 17?-hydroxy-7?-methyl-19-nor-17?-pregn-5(10)-en-20-yn-3-one (17?-ethynyl-17?-hydroxy-7?-methyl-5(10)-estren-3-one, tibolone) of formula 1, which comprises hydrolysis of 17?-ethynyl-17?-hydroxy-7?-methyl-5(10)-estrene 3,3-cyclic ketals of formula 2, where groups R1, R2, R3 and R4 are hydrogen atoms or alkyl groups, or R1 and R3, taken together with the carbon atoms within the dioxolane ring to which they are attached, form an alicyclic ring fused to the dioxolane ring, with R2 and R4 being hydrogen atoms, or R1 and R3 together with the carbon atoms to which they are attached form an aromatic ring fused to the dioxolane ring, where R2 and R4, taken together, form a chemical bond within said aromatic ring.
    Type: Application
    Filed: October 1, 2003
    Publication date: May 25, 2006
    Applicant: Institut Farmaceutyczny
    Inventors: Jacek Martynow, Andrzej Kutner, Wieslaw Szelejewski, Wanda Wojciechowska, Hanna Fitak
  • METHODS FOR PREPARATION OF OLANZAPINE POLYMORPHIC FORM I
    Publication number: 20050239772
    Abstract: The invention relates to the methods for preparation of olanzapine polymorphic Form I. The invention also provides new mixed solvates of olanzapine, which are valuable intermediates used in the preparation of pure olanzapine polymorphic Form I.
    Type: Application
    Filed: May 16, 2003
    Publication date: October 27, 2005
    Applicant: Institut Farmaceutyczny
    Inventors: Janina Piechaczek, Magdalena Glice, Urszala Fraczek, Jadwiga Serafin, Wieslaw Szelejewski, Krzysztof Soltysiak