Abstract: The invention concerns a process and a device for the determination of parameters of particles in electrolytes, in particular of biological particles, whereby the particles to be measured are flushed through a measure pore which consists of a multilayer system. The process is characterized in that the particles are alternatingly exposed to different electrical potentials during the passage and that the signals obtained due to the interaction of the different potentials with the particles are then combined with each other. Preferably, the signals measured with a temporal offset are combined so that the resulting signals have different signs. The device has a measurement pore made up of a multilayer system, whereby electrically conducting and nonconducting layers are disposed alternatingly and whereby the measurement pore runs crosswise through the various layers.