Abstract: The invention refers to the field of molecular biology and bio-organic chemistry and deals with a composition for immobilization in polymer carriers of oligonucleotides, proteins, nucleic acids or any other molecules, which structure comprises active groups, including amino- or sulfhydryl groups, as well as a method for immobilization of various molecules including oligonucleotides, proteins, nucleic acids or any other molecules which structure comprises active groups, including amino- or sulfhydryl groups, consisting of a porous polymer being obtained on the basis of the composition claimed under conditions of addition or substitution reaction (radical, nucleophilic, or electrophilic nature, etc.) during synthesis of polymer by photo- and chemical initiated polymerization.

Abstract: The invention provides a method for changing the genetic properties of an eukaryotic organism by suppression of expression of a target gene. Proposed method can be used in gene-therapy in medicine, agriculture, or industrial biotechnology. Genetic properties of an eukaryotic organism are changed by gene-specific silencing of a selected gene using small RNA molecules, that are complementary in a parallel orientation (pcRNAs) to mRNA of the selected gene; wherein pcRNAs are synthesized in vivo or in vitro on the artificial DNA sequence encoding pcRNA, said artificial DNA sequence possesses symmetrical nucleotide ordering (mirror inversion) in respect to the nucleotide sequence of the gene.

Abstract: The invention relates to molecular biology and bioorrganic chemistry and concerns compositions for immobilising modified oligonucleotides, proteins, nucleic acids and any other molecules carrying unsaturated groups in a hydrogel for producing microchips by means of a photo-induced copolymerisation. Said invention also relates to the production of microchips and a polymerase chain reaction (PCR) on a chip which are used in molecular biology for sequencing and mapping DNA, detecting mutations and for an entire range of medical applications.