Patents Assigned to Institut National De La Centre National De La Rechercher Scientifique
  • Oligonucleotides which inhibit expression of the OB-RGRP protein and method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor
    Publication number: 20050009042
    Abstract: The present application relates to oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions. It also relates to a method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor. This detection may be carried out by measuring the energy transfer between fusion proteins composed of these proteins and of energy-donor and -acceptor proteins.
    Type: Application
    Filed: February 9, 2004
    Publication date: January 13, 2005
    Applicants: Aventis Pharma S.A., Institut National De La Sante Et De La Racherche Medicale, Institut National De La Centre National De La Rechercher Scientifique
    Inventors: Ralf Jockers, Cyril Couturier, Eugen Uhlmann