Abstract: The invention relates to pseudo-peptides according to the formula:
wherein
R1 is a group inhibiting an amine function, or an amino acid residue or peptide with an inhibited terminal amino function,
R2 represents the lateral chain of a natural or non-natural amino acid,
R3 represents:
1) the lateral chain of a natural amino acid except for Gly and Ala, not substituted or substituted by an aryl group,
2) an aralkyl group, or
3) an alkyl group comprising at least 3 carbon atoms, and
R4 represents a lateral chain of natural or non-natural amino acid.
They are useful as matrix zinc metalloprotease inhibitors, particularly in the treatment of cancer.
Type:
Grant
Filed:
March 25, 2002
Date of Patent:
October 7, 2003
Assignees:
Commissariat a l'energie Atomique, Institut National de la Recherche Medical, Centre National de la Recherche Scientifique
Inventors:
Vincent Dive, Philippe Cuniasse, Marie-Christine Rio, Paul Basset, Athanasios Yotakis, Fabrice Beau, Stamania Vassiliou