Patents Assigned to Institut National De La Sante Et De La Racherche Medicale
  • METHODS FOR THE TREATMENT OF LEBER CONGENITAL AMAUROSIS
    Publication number: 20140179767
    Abstract: The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.
    Type: Application
    Filed: June 8, 2012
    Publication date: June 26, 2014
    Applicants: INSERM (Institut National de la Sante et de la Racherche Medicale), GENETHON, CNRS (Centre National de la Racherche Scientifique
    Inventors: Jean-Michel Rozet, Antoine Kichler, Isabelle Perrault, Josseline Kaplan, Xavier Gerard, Daniel Scherman
  • Oligonucleotides which inhibit expression of the OB-RGRP protein and method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor
    Publication number: 20050009042
    Abstract: The present application relates to oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions. It also relates to a method for detecting compounds which modify the interaction between proteins of the OB-RGRP family and the leptin receptor. This detection may be carried out by measuring the energy transfer between fusion proteins composed of these proteins and of energy-donor and -acceptor proteins.
    Type: Application
    Filed: February 9, 2004
    Publication date: January 13, 2005
    Applicants: Aventis Pharma S.A., Institut National De La Sante Et De La Racherche Medicale, Institut National De La Centre National De La Rechercher Scientifique
    Inventors: Ralf Jockers, Cyril Couturier, Eugen Uhlmann