Patents Assigned to Institut National de la Sante et de la Reserche Medicale
  • Patent number: 8293528
    Abstract: The invention relates to peptide compositions for use in the preparation of pharmaceutical compositions against hepatitis C virus, as well as corresponding methods.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: October 23, 2012
    Assignees: Transgene SA, INSERM (Institut National de la Sante et de la Reserche Medicale)
    Inventors: Geneviève Inchauspe, Anne Fournillier, Nourredine Himoudi, Perrine Martin
  • Patent number: 4540792
    Abstract: This invention relates to a process for the preparation of free L .alpha.-amino acids by the complete conversion of their D antipodes taken individually or possibly in racemic mixtures.The process according to the present invention is characterized in that the D antipodes of an ester of said .alpha.-amino acid is racemized in the presence of a chemical catalyst formed by at least one aromatic aldehyde corresponding to the general formula: ##STR1## wherein: Ar represents an aromatic ring optionally containing a heteroatom, such as nitrogen, andB represents a basic function,to produce a mixture in dynamic equilibrium of the two forms D and L of said ester, the ester which is present in the L form is hydrolyzed enzymatically and irreversibly to produce the corresponding stereostable L .alpha.-amino acid, said stages of chemical racemization and of enzymatic hydrolysis being carried out under identical reaction conditions, and the free L .alpha.-amino acid is recovered.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: September 10, 1985
    Assignees: Centre National de la Recherche Scientifique, Institut National de la Sante et de la Reserche Medicale
    Inventors: Auguste Commeyras, Aldo Previero, Martine Pugniere