Patents Assigned to Institut National de le Sante et de la Recherche Medicale
  • Probe for diagnosis of marfan syndrome and a method for screening using the probe
    Publication number: 20100209923
    Abstract: The purpose of this invention is to provide a probe for diagnosis of Marfan syndrome, which enables early diagnosis of Marfan syndrome, and to provide a method for screening using said probe. The invention is a probe for a Marfan Syndrome characterized by using a nucleic acid comprising following (a) or (b); (a) a nucleic acid comprising a base sequence represented by base numbers 1-180000 shown in SEQ ID No. 1 of the sequence listing, or (b) a nucleic acid in which a part of the base sequence of said base numbers 1-180000 is deleted, substituted or added, and having 80% homology with said base sequence.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 19, 2010
    Applicants: NAGASAKI UNIVERSITY, INSTITUT NATIONAL DE LE SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Norio Niikawa, Naomichi Matsumoto, Catherine Boileau, Gwenaielle Beroud, Guillaume Jondeau
  • Pharmaceutical composition which improves in vivo gene transfer
    Patent number: 7709452
    Abstract: The invention relates to a pharmaceutical composition which combines a tetrafunctional copolymer with a nucleic acid, said copolymer having formula I (namely a poloxamine), and preferably taking the form of one of the cationic mineral or organic salts thereof. The inventive composition can be used to improve in vivo gene transfer.
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: May 4, 2010
    Assignee: Institut National de le Sante et de la Recherche Medicale
    Inventor: Bruno Pitard
  • Proteins with urease activity
    Patent number: 6146634
    Abstract: The invention relates more particularly to any nucleotide sequence corresponding, according to the universal genetic code, to at least one part of the following amino acid sequence (VIII) of 61 kDa (coded by the nucleotide sequence (VII)):1MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTTYGEELKFGGGKTLREGM SQSNNPSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNN LSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPAD GTNATTTTPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGF KIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMH TFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLD KSIKEDVQFADSRIRPQTIAAEDTLHDMIGIFSITSSDSQAMGRVGEVTTRTWQT ADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISEYVGSVEVGKVADL VLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYD ANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETY HVFVDGKEVTSKPANKVSLAQLFSIF.sub.--.sbsb.569.Molecular weight: 61,729 daltons.The comparison between the aminoacid sequence (VIII) with the Jack bean urease sequence described in Eur. J. Biochem.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: November 14, 2000
    Assignee: Institut Pasteur and Institut National de le Sante et de la Recherche Medicale
    Inventor: Agnes Labigne