Abstract: A meat analogue may include a macrostructure of connected sheared fibers oriented parallel to one another and gaps positioned between the sheared fibers. The macrostructure may not include meat and may include a vegetable protein. An extrusion system may include an extruder and a die. The extrusion system may produce a meat analogue. A meat analogue may include a plant protein. The extruder may be connectable to the die. The extrusion system may be configured to direct a material including a vegetable protein from the extruder to the die and through a fluid path extending through the die. The die may be configured to inject a fat or a fat analogue into the material such that the fat or the fat analogue is embedded but visually distinct from the material including the vegetable protein when the fat or the fat analogue and the material exit the die.

Abstract: The invention is related to an inducible promoter for improved and regulated gene expression, useful in synthetic biology and metabolic engineering. In particular, the present invention relates to a nucleotide sequence comprising the regulatory regions of an erythritol- and erythrulose-inducible promoter in yeast and uses thereof in an expression system thus allowing an improved and regulated gene expression and production of gene product.

Abstract: A fusion protein including fragments of the spike protein and of the nucleoprotein of a coronavirus. Also a vaccine, a composition, a pharmaceutical composition, or a diagnostic kit including the fusion protein, a method for diagnosing an infection by a coronavirus and to a method for preventing or treating a coronavirus infection based on the use of the fusion protein.

Abstract: An optimised bio-electrochemical reactor for treating a liquid effluent containing a biodegradable organic pollution. At least one of the anode and cathode compartments of the reactor is a microbial biofilm compartment (12) including a multi-stage current collector immersed in an electrolyte comprising electroactive microorganisms. This current collector includes at least two stages, each defining a chamber acting as a container for a biocompatible granular support material and letting the fluid pass through. The effluent circulates inside the compartment (12) according to an X direction crossing the stages of the current collector. In operation, the support material (17) is in a fluidised state resulting either from the circulation of the effluent, or from the circulation of a fluidisation gas allowing optimising the active surface of the electrode and, consequently, the treatment of the effluent.

Abstract: An in vitro or ex vivo method for producing and isolating a cell subpopulation including T cells specific for an antigen linked to a disease of interest, which includes steps of obtaining, from an isolated human biological sample, a population of mononuclear cells including T cells specific for the antigen with a high proliferative capacity, culturing these mononuclear cells in a suitable cell culture medium containing the antigen, and isolating T cells specific to the antigen which do not express the CD45RO and CD27 markers at their surface. The cell subpopulation thus obtained and isolated finds application in particular for the treatment of the disease of interest.

Abstract: The present invention relates to genetically modified bacteria capable of inducibly expressing a nucleic acid sequence of interest, genetic constructs, vectors and uses thereof.

Abstract: A phytopharmaceutical method for treating a plant organ affected by a phytopathogenic fungal strain. The method includes the steps of applying on the plant organ a composition including at least one xanthone UPR (Unfolded Protein Response) inhibitor, preferably, an IRE-1 (Inositol-Requiring Enzyme 1) inhibitor, in a sub-effective amount. Also, a phytopharmaceutical composition including at least one UPR (Unfolded Protein Response) inhibitor in a sub-effective amount.

Abstract: The subject of the invention is a process for treating lignocellulosic biomass comprising the following steps: a) conditioning the lignocellulosic biomass, b) washing said particles, c) separating the aqueous solution from the washed biomass particles, d) impregnating said lignocellulosic substrate with an acid liquor, e) carrying out a solid/liquid separation of the impregnated lignocellulosic substrate, f) pretreating said substrate from step e) by cooking, g) carrying out an enzymatic hydrolysis of the pretreated lignocellulosic substrate, h) carrying out a fermentation of the hydrolyzate from step g), and introducing the used aqueous washing solution into a step of said biomass treatment process which is after the pretreatment step f), and/or into an enzyme production step and/or into a step of producing/propagating the microorganisms necessary for steps g) or h).

Abstract: The invention relates to gut microbiota profiles associated with response or resistance to treatments with ICB, in particular with anti-PD1 or anti PD-L1 or anti-PD-L2 antibodies. In particular, the invention pertains to a theranostic method for identifying good responders, to whom an anti-PD1 or anti PD-L1 or anti-PD-L2 can be administered, while a pre-treatment based on FMT and/or immunogenic probiotics is recommended to bad responders exhibiting a dysbiosis. In particular, the present invention pertains to Akkermansia muciniphila as the main commensal species distinguishing responders from progressors and its use alone or with E. hirae for the treatment of antibiotics or gut repertoire insufficiency-associated dysbiosis.

Abstract: An air-moving device (10) for pollinating at least one recipient plant using pollen collected on at least one donor plant includes a pollen collector for collecting pollen from the at least one said donor plant, and a distributor for distributing pollen on at least one recipient plant. A channel for conveying the pollen collected from the pollen collector to the distributor is provided. An air flow amplifier (18) employs Coanda effect for inducing a flow of air inside the conveying channel (16) from the pollen collector to the distributor for distributing the pollen. A pneumatic deflector deflects the Coanda effect flow of pollen disposed at the level of the pollen distributor.

Abstract: The present invention in general relates to enzymes with a polysaccharide oxidase activity. In particular, the invention relates to the field of second-generation ethanol production by oxidation and enzymatic hydrolysis of materials containing polysaccharides, in particular lignocellulosic biomass. The invention further relates to the field of celluloses, and to method for producing cellulose fibres and defibrillating cellulose substrates.

Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).

Abstract: The invention relates to the field of modified Escherichia coli strain Nissle 1917 (EcN) and its use for treating gastro-intestinal disorders. The invention is based on the study of the mechanisms implicated in the probiotic properties of the Escherichia coli strain Nissle 1917 (EcN). This study has allowed the inventors to decouple the probiotic activity of EcN from its genotoxic activity by demonstrating that EcN ClbP protein, the enzyme that activates the genotoxin colibactin, is also required for the siderophore-microcins activity of probiotic EcN, but interestingly, not its enzymatic domain that cleaves precolibactin to form active colibactin.

Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: The present invention relates to a plant obtained by mutagenesis, such that the expression and/or the activity of the ESK1 protein and the expression and/or the activity of the TPS7 protein are diminished compared to a non-mutagenated plant. Said plant with biomass that has better digestibility maintains satisfactory growth. A further aim of the present invention is a method for preparing said plant, as well as the use of said plant for the production of biofuel.

Abstract: The present invention relates to a system for spraying a product, notably a plant-protection product, comprising product spray nozzles (10) and airflow generating means (110), characterized in that the airflow generating means comprise an outlet (112) in the form of an annular slit designed to generate an airflow (102) in the form of a continuous tubular curtain of air enclosing the jets (12) emanating from the spray nozzles (10) and that the sprayed product cannot cross.

Abstract: The subject of the invention is a process for treating lignocellulosic biomass comprising the following steps: a) conditioning the lignocellulosic biomass, b) washing said particles, c) separating the aqueous solution from the washed biomass particles, d) impregnating said lignocellulosic substrate with an acid liquor, e) carrying out a solid/liquid separation of the impregnated lignocellulosic substrate, f) pretreating said substrate from step e) by cooking, g) carrying out an enzymatic hydrolysis of the pretreated lignocellulosic substrate, h) carrying out a fermentation of the hydrolyzate from step g), and introducing the used aqueous washing solution into a step of said biomass treatment process which is after the pretreatment step f), and/or into an enzyme production step and/or into a step of producing/propagating the microorganisms necessary for steps g) or h).

Abstract: A combination of agents capable of binding an infectious agent, such as an antibody, an antibody derivative, or an antibody mimetic, and immunomodulatory agents, such as probiotic strains, for the treatment or prevention of respiratory infections, in particular bacterial respiratory infections. The agents capable of binding an infectious agent are administered by inhalation.

Abstract: The present invention relates to novel plants displaying an improved resistance to nematodes. The present invention also relates to seeds and parts of said plants. The present invention further relates to methods of making and using such seeds and plants. The present invention also relates to a novel SmD1 allele, which results in a modified SmD1 protein associated with such improved resistance to nematodes.