Abstract: The present invention relates to polypeptides encoded by a nucleotide sequence from an HIV-1, HIV-2, or SIV viral genome, in which the nucleotide sequence is amplified from the viral genome using a pair of primers that contain sequences that are conserved between different HIV and SIV strains. The primers are insensitive to variations in the genomes of different HIV and SIV isolates and, therefore, can be used to amplify nucleotide sequences from HIV-1, HIV-2, and SIV strains. The invention also relates to antibodies directed against these polypeptides and methods and kits for diagnosing viral infection.
Type:
Grant
Filed:
September 26, 2000
Date of Patent:
April 4, 2006
Assignee:
Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
Abstract: The present application relates to nucleotide sequences which regulate the biosynthesis of the flagella proteins Helicobacter pylori, to the proteins encoded by these sequences and to aflagellate bacterial strains. The invention also relates to the use of these means for detecting an infection due to H.pylori or for protecting against such an infection.
Type:
Grant
Filed:
January 29, 1998
Date of Patent:
January 4, 2005
Assignee:
Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
Abstract: The present application relates to nucleotide sequences which regulate the biosynthesis of the flagella proteins Helicobacter pylori, to the proteins encoded by these sequences and to aflagellate bacterial strains. The invention also relates to the use of these means for detecting an infection due to H.pylori or for protecting against such an infection.
Type:
Application
Filed:
September 10, 2002
Publication date:
October 16, 2003
Applicant:
Institut Pasteur and Institut National De La Sante Et De La Recherche Medicale
Abstract: This invention relates to the detection and analysis of viral protein-protein interactions using a two-hybrid system. This invention allows the definition and use of minimal peptides involved in these protein-protein interactions. In particular, this invention relates to the use of a two-hybrid assay to screen for molecules that interact with hepatitis C virus proteins.
Type:
Application
Filed:
September 26, 2001
Publication date:
August 1, 2002
Applicant:
Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
Inventors:
Pierre LeGrain, Marc Flajolet, Giuseppe Rotondo, Catherine Transy, Genevieve Inshauspe
Abstract: An altered MHC class I determinant comprises .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .beta..sub.2 -microglobulin (.beta..sub.2 m) polypeptide domains encoded by a mammalian MHC class I locus in which the .alpha..sub.3 domain is covalently linked to the .beta..sub.2 M domain. An altered MHC class II determinant comprises .alpha..sub.1, .alpha..sub.2, .beta..sub.1, and .beta..sub.2 polypeptide domains encoded by a mammalian MHC class II locus, in which the domains are covalently linked to form a polypeptide comprising the .beta..sub.2 -.alpha..sub.2 -.alpha..sub.1 -.beta..sub.1 domains in sequence. The altered MHC class I and class II determinants can be associated with an antigen to elicit an immune response. The invention can be used in the immunization or treatment of diseases such as AIDS, multiple sclerosis, lupus erythematosus, toxic shock or snake bite.
Type:
Grant
Filed:
January 9, 1995
Date of Patent:
November 28, 2000
Assignee:
Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
Inventors:
Jean-Pierre Abastado, Estelle Mottez, Philippe Kourilsky, Armanda Casrouge, David Ojcius, Yu-Chun Lone
Abstract: The invention concerns a composition useful for the manufacture of vaccines containing particles having the immunogenic properties characteristic of the antigen HBsAg, these particles being more particularly characterized by the fact that the particles equally contain a receptor for polymerized human albumin. They are obtained by transformation of human or animal cells by a vector containing a DNA sequence coding for the S and pre-S regions of a genome of viral hepatitis B, this DNA sequence being placed under the direct control of a promoter permitting the effective transcription of the sequence in the human or animal cells transformable by the vector.
Type:
Grant
Filed:
February 6, 1995
Date of Patent:
April 18, 2000
Assignee:
Institut Pasteur, Institut National de la Sante et de la Recherche Medicale and Centre National de la Recherche Scientifique
Inventors:
Elaine Sobczak, Yves Malpiece, deceased, Marie-Louise Michel, Pierre Tiollais, Rolf E. Streeck
Abstract: The present invention provides papillomavirus DNA, and more particularly DNA probes derived from papillomavirus. The present invention also provides procedures for the use of DNA derived from papillomavirus in the in vitro diagnosis of papillomavirus infections.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
January 4, 2000
Assignee:
Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
Inventors:
Carol Ann Komly, Odile Croissant, Francoise Breitburd
Abstract: The invention relates to the DNAs of papillomaviruses, and more particularly to the probes derived from these papillomaviruses, as well as procedures for their implementation in the in vitro diagnosis of papillomavirus infections.
Type:
Grant
Filed:
April 21, 1995
Date of Patent:
September 21, 1999
Assignee:
Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
Inventors:
Carol Ann Komly, Odile Croissant, Francoise Breitburd
Abstract: The present invention provides papillomavirus polypeptides and antibodies against said polypeptides. The peptides and antibodies of the present invention are particularly useful for in the prevention, diagnosis, and treatment of infections caused by distinct papillomaviruses. These papillomaviruses are linked to distinct infectious states. The polypeptides of the present invention are derived from L2 genes of different papillomaviruses (or from a portion of said genes). The present invention further provides kits containing one or more antibodies according to the present invention, and a method for the detection and identification of papillomaviruses in biological samples by immunological reaction with said antibodies. The diagnostic kits of the present invention are suitable for diagnosis of the specific infection affecting the donor subject of the biological sample, or infections to which the subject risks being exposed.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
July 6, 1999
Assignee:
Institut Pasteur and Institut National de la Sante et de la Recherche Medicale
Inventors:
Carol Ann Komly, Odile Croissant, Francoise Breitburd