Abstract: The present disclosure relates to a method of preventing or treating an infectious disease in a subject, comprising the step of administering to the subject an antagonist or expression inhibitor for a natural killer (NK) cell immune checkpoint molecule. The present disclosure also relates to the use of an antagonist or expression inhibitor for an NK cell immune checkpoint molecular and pharmaceutical compositions comprising the same in the treatment of infectious diseases.
Type:
Application
Filed:
March 20, 2020
Publication date:
May 12, 2022
Applicant:
INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
Abstract: Provided is a method for activating CD4+ T cells using a polymer-based antigen complex. The method comprises the steps of bringing the polymer-based antigen complex into contact with B cells so that B cells process and present the antigen complex, and of bringing the B cells into contact with CD4+ T cells to activate CD4+ T cells. Also provided are a method for promoting the differentiation of CD4+ T cells into Tfh cells and Thl cells using the antigen complex, and a method for treating diseases by activating CD4+ T cells and/or promoting the differentiation of CD4+ T cells.
Type:
Application
Filed:
August 6, 2019
Publication date:
April 14, 2022
Applicants:
INSTITUTE OF BIOPHYSCIS, CHINESE ACADEMY OF SCIENCES, INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
Inventors:
Baidong HOU, Sheng HONG, Zhaolin HUA, Hong TANG
Abstract: The present invention provides a composition and a combined medication method for treating an enterovirus infection. In particular, the present invention provides a composition for inhibiting enteroviruses, wherein the composition at least contains an inhibitor of a 3D virus protein and an inhibitor of a capsid protein, or a combination of an inhibitor of a 3C protein and an inhibitor of a 3A protein.
Type:
Grant
Filed:
January 11, 2017
Date of Patent:
December 15, 2020
Assignee:
INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
Abstract: A method for the treatment and/or the prevention of a disease or a symptom related to dysfunction of regulatory T cell immunomodulation includes administering to a subject in need thereof compositions that regulate regulatory T cell immunomodulatory function, in which the compositions may be prepared by contacting starting materials with phosphorylation pathway-related factors, the agonists or the antagonists thereof. The phosphorylation pathway-related factors are selected from: proto-oncogene protein PIM1 and the coding sequence thereof. The regulation is achieved by regulating the activity of regulators of regulatory T cells selected from the group: FOXP3, IL-2, GITR, CTLA4, and a combination thereof.
Type:
Application
Filed:
March 9, 2017
Publication date:
July 6, 2017
Applicant:
Institut Pasteur of Shanghai, Chinese Academy of Sciences
Inventors:
Bin Li, Zhiyuan Li, Fang Lin, Zhimei Gao, Zuojia Chen, Andy Tsun, Kongchen Li
Abstract: The present invention relates to methods and applications of using Drosophila cells to produce virus-like particles. Virus-like particles of enveloped viruses produced by the methods of the present invention have proteins correctly expressed, cleaved, and assembled. Ultimately, virus-like particles having good immunogenicity are obtained. The present invention also provides recombinant cells expressing virus-like particles and compositions containing virus-like particles.
Type:
Application
Filed:
March 19, 2012
Publication date:
January 2, 2014
Applicant:
INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
Inventors:
Paul Zhou, Yufeng Song, Fan Zhou, Lifei Yang, Cheguo Cai, Heng Ding