Abstract: A high-efficiency anti-tumor nano-drug delivery system containing hydralazine (hydralazine-nanoparticles abbreviated as H-NPs) is provided. The drug delivery system takes hydralazine and doxorubicin combined by a ?-? bond as a hydrophobic core and takes dextran as a hydrophilic shell. The high-effective anti-tumor nano-drug delivery system containing hydralazine can increase the vascular permeability and blood perfusion of the tumor site, improve the enrichment and penetration of nanoparticles in the tumor, reduce tumor hypoxia, increase the sensitivity of the tumor to a chemotherapy drug doxorubicin, and significantly improve its anti-tumor effect by expanding the tumor blood vessels and regulating tumor microenvironment (TME).

Abstract: A method for preparation of a self-cleaning coating solution is provided. The method comprises mixing an aluminium compound with a solution of an ethanol compound to form a solution. Further, the formed solution is subjected to a first magnetic stirring. After the first magnetic stirring a first transparent solution is formed. Further, a stabilizing agent is added to the first transparent solution of the aluminium compound and the ethanol compound. Subsequent to adding the stabilizing agent a translucent solution is formed. Finally, the formed translucent solution is subjected to a second magnetic stirring for forming a homogeneous second transparent solution.

Abstract: The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

Abstract: The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

Abstract: The present invention relates to a random-number generating apparatus and method for generating physical random numbers in accordance with noises randomly generated by a noise generating element, and allows for generating true random numbers at a high speed and uniformizing the generation frequency of each random number value, even in a simplified circuit configuration. The random-number generating apparatus is operable to amplify a waveform based on thermal noises generated in a thermal-noise generating element, and generate a random pulse at the time when the amplified output signal exceeds a given threshold from the state of being less than the threshold. The random-number generating apparatus is also provided with a reference-pulse generator for generating a reference pulse having a constant period, and a timer for measuring a time interval between the reference pulse and the random pulse. The measured value in the timer is output as a random number value.

Abstract: Disclosed is a method for deriving random numbers at a higher speed than ever before while maintaining desired randomness without spoiling uniformity of the occurrence frequency of each random number. One pulse included in one of two or more mutually-independent random pulse sequences and one pulse included in one of the remaining random pulse sequences are used, respectively, as a start pulse and a stop pulse. Then a time interval between the start pulse and the stop pulse is measured, and the measured value is output. The pulses temporally occur in a random manner, and therefore the obtained sequence of numerical values becomes random numbers. Specifically, in FIG. 1, time intervals t1 to t4 are measured, and these measured values (in FIG. 1, four values) are derived as random numbers.

Abstract: The invention relates to inhibitory nucleotide signal sequences or “INS” sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

Abstract: An algorithm for identification of microRNA (miRNA) targets within viral and cellular RNA is disclosed. Also disclosed are essential herpes virus genes whose transcripts contain one or more targets of miRNAs encoded by herpes viruses or by host cells as predicted by the algorithm, and the use of such targets, miRNAs and their derivatives for modulating viral replication and latency.

Abstract: A neural network architecture has phase-coherent alternating current neural input signals. Each input v.sub.k.sup.in is a two-phase pair of signals 180 degrees out of phase. Capacitive coupling of both signals of n input pairs to a summation line gives a non-dissipative realization of the weighted sum ##EQU1## with general real neural weights w.sub.ik. An alternating current offset signal proportional to u.sub.i is also capacitively coupled to the summation line. The signal on the summation line is passed through a low input capacitance follower/amplifier, a rectifier and a filter, producing a direct current signal proportional to the magnitude ##EQU2## This signal is compared with a direct current threshold proportional to t.sub.i, and the resultant is used to gate a two-phase alternating current output signal. The output is therefore functionally related to the inputs by ##EQU3## with .theta. the Heaviside step function.