Patents Assigned to Institute of Applied Biochemistry Gifu-ken
  • Plasmid entrapping multilamellar liposomes
    Patent number: 5744159
    Abstract: A plasmid entrapping multilamellar liposome for introducing a gene into cells, which liposome has constitutive lipids of N-(.alpha.-trimethylammonioacetyl)-didodecyl-D-glutamate chloride (TMAG); dioctanoylphosphatidyl choline (DOPC) or didecanoylphosphatidyl choline (DDPC); and dioleoylphosphatidyl ethanolamine (DOPE) or dilauroylphosphatidyl ethanolamine (DLPE) and in a molar ratio of 1:2-3:2-1 in case of lipid combination of TMAG, DOPC and DOPE, or 1:2:2 in case of lipid combination of TMAG, DDPC or DOPC and DLPE.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: April 28, 1998
    Assignee: Institute of Applied Biochemistry Gifu-ken
    Inventors: Kunio Yagi, Mariko Kitoh, Nobuko Ohishi