Abstract: The present invention discloses an imaging method and an apparatus for direct electron detection cameras and a computer device, and relates to the technical field of electron microscope cameras. The present invention is mainly capable of improving the signal-to-noise ratio (SNR) of an image so as to improve the detective quantum efficiency of electron. The method includes the steps of classifying clusters in an original image to obtain low SNR clusters and high SNR clusters; performing three-dimensional reconstruction by using the images corresponding to the low SNR clusters and the high SNR clusters, respectively, to obtain three-dimensional models corresponding to the low SNR clusters and the high SNR clusters, respectively; performing filtering on the image corresponding to the low SNR clusters by using the filtering function, and superimposing the image to obtain m output image corresponding to the vitrified sample.

Abstract: A calibration system for magnetometers includes magnetometers configured to measure a magnetic field to be measured; a magnetometer holder fixedly mounted on the magnetometer holder; at least one magnetic field generating device having its position fixed relative to the magnetometers, and used to generate a calibration magnetic field distribution in a space to be measured; and a calculation device configured to calculate the magnitudes of magnetic field vectors at the positions of the magnetometers according to the calibration magnetic field distribution generated by the at least one magnetic field generating device in the space to be measured, receive measured magnitudes of the magnetic field vectors from the magnetometers, and calculate detection gain values of the magnetometers on the basis of the calculated magnitudes of the magnetic field vectors and the measured magnitudes of the magnetic field vector.

Abstract: A fully-automatic protein purification system device includes a chromatography unit, a first drive unit, a connecting pipeline, a locating unit, a second drive unit, a first container, a second container, a first valve, a second valve, and a control unit. The fully-automatic protein purification system device can fully automate the protein chromatography purification with a simple device structure and a low cost, has low requirements for the quality of a sample solution, will not cause blockage of a pipeline, has a wide application range, can greatly improve the automation of protein chromatography purification in the biology field, and can reduce the manual investment.

Abstract: A system and a method for spatial positioning of magnetometers. Said system includes: magnetometers, a magnetometer support, first positioning markers, a photogrammetry system, and a controller. The first positioning markers are a non-rotationally-symmetrical pattern. The photogrammetry system includes photographing devices configured to photograph, at at least two of a plurality of photographing sites, first image data of the first positioning markers by means of one or more photographing devices. The controller is configured to receive data of the first image photographed by the photographing devices, calculate spatial positions of the first positioning markers on the basis of pre-obtained system parameters and the first image data, and then calculate spatial positions and spatial orientations of the magnetometers.

Abstract: A composition is provided for promoting skeletal muscle oxidative muscle fiber generation. The composition comprises a Lycium barbarum water extract. The Lycium barbarum extract comprises polysaccharide, Lycium barbarum flavone, carotenoid, polyphenol, and Lycium barbarum pigment. The composition may further comprise one or more pharmaceutically acceptable excipients selected from such as a solvent, a co-solvent, an emulsifier, a preservative, a buffer, a protein powder, or a combination thereof. The composition may be used as medicine, functional product, or food supplement.

Abstract: Provided in the present invention is a method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro, which is achieved by maintaining, amplifying and culturing pluripotent stem cells in vitro, adding a substance capable of activating the Smad1/5/8 signaling pathway directly or indirectly into the culture medium when pluripotent stem cells are in the middle stage of myocardial differentiation, i.e. the period of differentiating into cardiac muscle cells from mesoderm cells or myocardial precursor cells, which enables stem cells to differentiate into ventricular myocytes directionally.

Abstract: Disclosed is a multi-channel atomic magnetic detector (100), including at least one detection assembly, with each detection assembly including a plurality of detection air chambers (130) in the same plane and a light-splitting member (110) for allocating polarized beams from a light source (180) to each detection air chamber (130) in the detection assembly, wherein the plurality of detection air chambers (130) of each detection assembly are arranged in a centrally symmetric manner or an axially symmetric manner relative to the light-splitting member (110). The multi-channel atomic magnetic detector (100) has a high detection density and is beneficial for noise reduction.

Abstract: Provided in the present invention is a method for inducing pluripotent stem cells to differentiate into ventricular myocytes in vitro, which is achieved by maintaining, amplifying and culturing pluripotent stem cells in vitro, adding a substance capable of activating the Smad1/5/8 signaling pathway directly or indirectly into the culture medium when pluripotent stem cells are in the middle stage of myocardial differentiation, i.e. the period of differentiating into cardiac muscle cells from mesoderm cells or myocardial precursor cells, which enables stem cells to differentiate into ventricular myocytes directionally.

Abstract: A composition is provided for promoting skeletal muscle oxidative muscle fiber generation. The composition comprises a Lycium barbarum water extract. The Lycium barbarum extract comprises polysaccharide, Lycium barbarum flavone, carotenoid, polyphenol, and Lycium barbarum pigment. The composition may further comprise one or more pharmaceutically acceptable excipients selected from such as a solvent, a co-solvent, an emulsifier, a preservative, a buffer, a protein powder, or a combination thereof. The composition may be used as medicine, functional product, or food supplement.

Abstract: The present invention provides a recombinant protein or a derivative thereof, wherein the recombinant protein has an amino acid sequence of the N-terminal portion of CC chemokine receptor 4 (CCR4). The invention also provides the use of the recombinant protein or a derivative thereof for treating or preventing a disease or condition associated with CCR4 signaling, such as an allergic disease, inflammatory enteritis, psoriasis, an inflammatory skin disease, vasculitis, spondyloarthropathy, scleroderma, asthma, a respiratory allergic disease, an autoimmune disease, graft rejection, leukemia, lymphoma, a blood-borne cancer, a disease requiring inhibition of undesirable inflammation, and a cancer.

Abstract: Disclosed is a multi-channel atomic magnetic detector (100), including at least one detection assembly, with each detection assembly including a plurality of detection air chambers (130) in the same plane and a light-splitting member (110) for allocating polarized beams from a light source (180) to each detection air chamber (130) in the detection assembly, wherein the plurality of detection air chambers (130) of each detection assembly are arranged in a centrally symmetric manner or an axially symmetric manner relative to the light-splitting member (110). The multi-channel atomic magnetic detector (100) has a high detection density and is beneficial for noise reduction.

Abstract: The present disclosure discloses monoclonal antibodies binding to type I interferon alpha receptor and their uses. The antibodies are capable of inhibiting the biological activity of type I interferons, and can be used for treating, preventing, or diagnosing the diseases mediated by the type I interferons. Also provided are immunoconjugate, bispecific molecule and pharmaceutical compositions comprising the antibodies of the present disclosure.

Abstract: A composition is provided for promoting skeletal muscle oxidative muscle fiber generation. The composition comprises a Lycium barbarum water extract. The Lycium barbarum extract comprises polysaccharide, Lycium barbarum flavone, carotenoid, polyphenol, and Lycium barbarum pigment. The composition may further comprise one or more pharmaceutically acceptable excipients selected from such as a solvent, a co-solvent, an emulsifier, a preservative, a buffer, a protein powder, or a combination thereof. The composition may be used as medicine, functional product, or food supplement.

Abstract: A composition is provided for promoting skeletal muscle oxidative muscle fiber generation. The composition comprises a Lycium barbarum water extract. The Lycium barbarum extract comprises polysaccharide, Lycium barbarum flavone, carotenoid, polyphenol, and Lycium barbarum pigment. The composition may further comprise one or more pharmaceutically acceptable excipients selected from such as a solvent, a co-solvent, an emulsifier, a preservative, a buffer, a protein powder, or a combination thereof. The composition may be used as medicine, functional product, or food supplement.

Abstract: An IFN-anti-PD-L1 fusion protein, a pharmaceutical composition and a kit containing the same for treating tumors are disclosed. The IFN-anti-PD-L1 fusion protein of the present invention can simultaneously target PD-L1 and IFN receptors, and the activation of IFN signals in a tumor microenvironment (TME) can enhance the PD-1/PD-L1 therapy against tumors by inducing stronger T cell activation. The anti-PD-L1 antibody can be used to specifically deliver immunomodulatory molecules to tumor tissues, and the fusion protein results in the generation of multiple feedforward responses, which can increase the targeting effect, reduce the toxicity, and enhance the response to IFN therapy, thereby maximizing the anti-tumor effect.

Abstract: A preparation method of adiposomes, and use thereof. Provided is a method for preparing adiposomes consisting of neutral lipids and a monolayer phospholipid membrane, comprising a1) vortexing phospholipid and neutral lipids in a buffer, centrifuging the resulting mixture, and collecting an upper liquid phase; a2) purifying the upper liquid phase twice or more by uniformly mixing the upper liquid phase with the buffer, layering the mixture, and collecting an upper liquid phase; and a3) uniformly mixing the upper liquid phase obtained in step a2) with the buffer, layering the mixture, and collecting a lower liquid phase in containing adiposomes. For the adiposomes prepared by the method, one or more resident proteins and/or functional proteins can be recruited to obtain artificial lipid droplets, and one or more apolipoproteins can be recruited to obtain artificial lipoproteins; and they all play important roles in preparing drugs and/or drug carriers.

Abstract: The present invention relates to a method of treating, mitigating, minimizing, or preventing HIV-1/AIDS by administering a CD24 protein to a subject in need thereof. Also provided herein is use of a CD24 protein in the manufacture of a medicament for treating HIV-1/AIDS. Further, provided is a pharmaceutical composition comprising a pharmaceutically acceptable amount of a CD24 protein.

Abstract: The present invention discloses novel compositions and methods for enhancing cardiac differentiation efficiency of stem cells or promoting ventricular and atrial cardiomyocytes formation from stem cells. The present invention also discloses the atrial and ventricular cardiomyocytes formed from the stem cells, and the uses of the cardiomyocytes for repairing cardiac injuries and screening for new medicaments for treating cardiac injuries.

Abstract: The present invention provides applications of a small molecular flavonoid compound in preparing a medication for sensitizing/synergizing tumor radiation therapy as well as reducing radioactive damage. The small molecular flavonoid compound can be naringenin, hesperetin, luteolin and apigenin, etc. The medication contains a small molecular flavonoid compound and a plurality of conventional pharmaceutical additives; wherein the small molecular flavonoid compound is an active ingredient.

Abstract: In one aspect, the present disclosure relates to a substantially albumin-free, chemically defined medium for efficiently supporting stem cell differentiation with significantly improved reproducibility and long-term culture of the differentiated cells. In particular embodiments, provided herein are compositions and methods for promoting atrial and ventricular cardiomyocytes formation from stem cells. The present disclosure further relates to the atrial and ventricular cardiomyocytes formed from the stem cells, and the uses of the cardiomyocytes, e.g., for cardiac injury repairmen, cardiac safety evaluation during drug discovery, and screening for new therapeutics for treating cardiac injuries.