Abstract: Provided are a platelet-derived growth factor B derivative, the encoding nucleic acid molecule thereof, and a vector and host cell having the nucleic acid molecule. Also provided are a preparation method for the mutant, and the use of the mutant in preparing medications for promoting cell division, cell proliferation, wound healing, skin regeneration, bone and tooth defect regeneration, and joint repair.
Type:
Grant
Filed:
July 16, 2015
Date of Patent:
October 22, 2019
Assignee:
Institute of Biotechnology Academy of Military Medical Sciences P.L.A. China
Inventors:
Wei Chen, Xiaopeng Zhang, Changming Yu, Ling Fu, Mengmeng Dai, Jun Zhang, Junjie Xu, Lihua Hou, Jianmin Li
Abstract: Provided are a platelet-derived growth factor B derivative, the encoding nucleic acid molecule thereof, and a vector and host cell having the nucleic acid molecule. Also provided are a preparation method for the mutant, and the use of the mutant in preparing medications for promoting cell division, cell proliferation, wound healing, skin regeneration, bone and tooth defect regeneration, and joint repair.
Type:
Application
Filed:
July 16, 2015
Publication date:
September 7, 2017
Applicant:
Institute of Biotechnology Academy of Military Medical Sciences P.L.A. China
Inventors:
Wei CHEN, Xiaopeng ZHANG, Changming YU, Ling FU, Mengmeng DAI, Jun ZHANG, Junjie XU, Lihua HOU, Jianmin LI