Abstract: A new and distinct Malus Mill. apple tree variety is provided which exhibits a columnar tree type, moderate growth vigor, and Vf-resistance against scab. The new variety yields late maturing and ornamental fruits. The fruit color medium red and the fruit size is large relative to other ornamental apples.

Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.

Abstract: This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.

Abstract: Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the following general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for application to mammalian cells, and especially human skin cells, in order to improve the cosmetic appearance of the mammalian cells, especially human skin.

Abstract: The present invention relates to a compound of formula I, or a pharmaceutically acceptable acid salt thereof. The invention further relates to the use of such compounds in the treatment of hyperproliferative skin disorders, viral infections, cancer, rheumatoid arthritis, lupus, type I diabetes, multiple sclerosis, restenosis, polycystic kidney disease, graft rejection, graft versus host disease and gout, or for psoriasis, parasitoses such as those caused by fungi or protists, or Alzheimer's disease. Further aspects of the invention relate to the use of such compounds in the inhibition of cell proliferation, in the induction of apoptosis, to modulate the activity of adrenergic and/or purinergic receptors or to suppress immunostimulation. The invention also relates to the use of 2,6,9-trisubstituted 8-azapurines in maintaining mammalian ooctyes at the germinal vesicle stage.

Abstract: The invention relates to 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I and pharmaceutically acceptable salts thereof, wherein R3 is an optionally substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl alkyl, aryl or alkylaryl group; R5 is halogen, —NHNH2, —NHOH, NHCONH2, guanylo (NH—C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkynyl, C3-C15 cycloalkyl, Rf(C3-C15 cycloalkyl), heterocyclyl, heteroalkyl, aryl, heteroaryl, arylalkylene, arylalkenylene, arylalkynylene, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkylene, heteroarylalkenylene, heteroarylalkynylene group, the group —C(O)—Ra, —C(O)NRbRc, —SO3Rd, or —NHC(O)Re, wherein Ra and Rf are an optionally substituted C1-C6 alkyl, alkenyl, or alkynyl group, Rb, Rc, and Rd are independently selected from the group consisting of H, optionally substituted C1-C6 alkyl, alkenyl, or alkynyl group, and Re is a hydroxy, amino, alkoxy, alkylamino, optionally substituted C1-C6 alkyl, alkenyl or

Abstract: A new and distinct Malus Mill. plant that produces crisp, juicy apples having a harmonious sugar-acid balance and excellent keeping quality, suitable for use as a dessert fruit.

Abstract: The ‘Red Topaz’ apple tree originated as a spontaneous limb sport mutation discovered on a ‘Topaz’ apple tree. ‘Red Topaz’ is distinguishable from its parent by its fruit. ‘Red Topaz’ has a solid red overcolor and matures about ten days earlier than ‘Topaz.

Abstract: A new and distinct Malus Mill. plant that produces large, juicy apples having an excellent sugar-acid balance and good keeping quality, suitable for use as a dessert fruit.

Abstract: A new and distinct Malus domestics (Borkh.) apple tree variety is provided which exhibits a columnar tree type, compact growth, predominant bearing on spurs and Vf-resistance against scab. The new variety yields late maturing, medium-sized, generally globose to obloid yellow-colored apple fruits having a firm and crispy flesh with very good eating and keeping qualities.

Abstract: A new and distinct Malus domestica (Borkh.) apple tree variety is provided which exhibits a columnar tree type, weakly vigorous compact growth, predominant bearing on spurs and Vf-resistance against scab. The new variety yields late maturing, medium-sized, globose-conical to conical fruits having good storage quality. The fruit color is yellow-green to yellow with a partial red to orange blush. The fruits have a yellow-colored firm flesh that is crisp and juicy with a good sweet/sour balance and very good eating quality.

Abstract: A new and distinct Malus domestica (Borkh.) apple tree variety is provided which exhibits a columnar tree type, moderate growth vigor, and Vf-resistance against scab. The new variety yields late maturing and ornamental fruits. The fruit color is medium red and the fruit size is large relative to other ornamental apples.

Abstract: A new and distinct Malus domestica (Borkh.) variety that exhibits a slightly upright to spreading tree habit, medium-high vigor, medium dense pyramidal tree form, bears a Vf-resistance gene against scab, and has high and regular yields without the need of fruit thinning. The new variety provides late maturing, medium-sized, cylindrical globose-shaped, and homogenous bright red fruits that are russet free. The fruit flesh is firm, crisp, and juicy, with a finely sour and slightly aromatic flavor. The fruits of the new variety exhibit good eating and keeping qualities.

Abstract: A new and distinct dessert diploid variety of Malus domestica Borkh. that is characterized by very early to early time of harvesting and eating maturity and polygenic resistance against scab. The new variety has a ramified tree type of medium vigor and a spreading tree habit. Fruits are small to medium sized, with a globose-conical shape, yellow ground color, and red overcolor. The fruit flesh has medium firmness, is very juicy, and has a sweet aroma. Bloom, greasiness, and russeting are absent. The variety suits well for organic production as for a home garden.

Abstract: A new and distinct dessert diploid variety of Malus domestica (Borkh.) that is characterized by Vf-resistance against scab, drooping tree habit, moderate vigor, and globose fruits of medium size which have a large area of red to red-purple overcolor with weakly defined stripes. The fruit flesh is firm, crisp, juicy, and with a pleasant aroma. The new variety has a late time of harvest and a medium to late time of eating maturity.

Abstract: A new and distinct Malus domestica (Borkh.) late ripening, dessert variety that exhibits a columnar tree growth type, very narrow growth habit, Vf-resistance against scab, and bright red fruits having good taste and storability. The new variety is suitable for home apple growing as solitary trees or in groups to function as hedges. The new variety is also suitable for commercial apple production for the juice industry.

Abstract: A new and distinct Malus domestica (Borkh.) late ripening, dessert variety that exhibits weak vigor, extensive branching, Vf-resistance against scab, and medium-sized, dark red fruits with rare russeting. The fruits of the new variety are very sweet with very low acidity and taste similar to tropical fruits.

Abstract: A new and distinct Malus domestica (Borkh.) ornamental variety that exhibits a columnar tree growth type, compact growth habit, Vf-resistance against scab, attractive red-purple flowers, greyed-purple young leaves, green mature leaves, and small, red colored, obloid shaped fruits that persist on the tree after the fall of leaves into Winter. The new variety is suitable for home apple growing as solitary trees and can be useful for pollinating purposes.

Abstract: A new and distinct Malus domestica (Borkh.) ornamental variety that exhibits a columnar tree growth type, very narrow growth habit that is generally free of side branches, Vf-resistance against scab, attractive red-purple flowers, greyed-purple young leaves, and small, red to red-purple colored, broadly globose shaped fruits that persist on the tree after the fall of leaves until the end of Winter. The new variety is suitable for home apple growing as solitary trees and can be useful for pollinating purposes.

Abstract: A new and distinct Malus domestica (Borkh.) medium to late ripening, dessert variety that exhibits a columnar tree growth type, Vf-resistance against scab, and yellow fruits having a very good taste that are suitable for eating immediately or shortly after harvesting. The new variety is preferable for home apple growing as solitary trees or in groups to function as hedges.