Patents Assigned to Institute of Materia Medica, Chinese Academy of Medical Sciences
  • Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use
    Patent number: 6787564
    Abstract: The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and neurodegenerative disease such as cerebral ischemia, Alzheimer disease and vascular dementia.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: September 7, 2004
    Assignee: Institute of Materia Medica, Chinese Academy of Medical Sciences
    Inventors: Juntian Zhang, Liang Huang, Kemei Wu, Shiming Chen
  • Novel optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use
    Publication number: 20030207935
    Abstract: The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and neurodegenerative disease such as cerebral ischemia, Alzheimer disease and vascular dementia.
    Type: Application
    Filed: March 26, 2002
    Publication date: November 6, 2003
    Applicant: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Juntian Zhang, Liang Huang, Kemei Wu, Shiming Chen
  • Agarofuan derivatives, their preparation, pharmaceutical composition containing them and their use as medicine
    Patent number: 6486201
    Abstract: The compound represented by formula (I), in which the substitutes are defined as in the specification and the claims, or their stereoisomers, the process for preparing them, pharmaceutical composition containing them and their use as medicine.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: November 26, 2002
    Assignee: Institute of Materia Medica, Chinese Academy of Medical Science (CN)
    Inventors: Jiyu Guo, Weijun Wang, Hongju Fang, Qian Liu, Wuyan Zhang, Dali Yin, Sujuan Sun, Ruiwu Liu, Chun Li, Haifan Liu, Donghui Wang
  • N-substituted amide derivatives useful for treating liver diseases
    Patent number: 4937360
    Abstract: N-substituted amide derivative represented by the formula ##STR1## wherein A is --CH(OH)-- or --C(.dbd.O)--, R.sup.1 is a hydrogen atom or an lkyl group having 1 to 3 carbon atoms, and R.sup.2 is an alkyl group having 1 to 6 carbon atoms, are disclosed. These compounds are useful for prevention and therapy for liver diseases.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: June 26, 1990
    Assignees: Taisho Pharmaceutical Co., Ltd., The Institute of Materia Medica of Chinese Academy of Medical Sciences
    Inventors: Geng-tao Liu, Liang Huang, Er-chang Rao, Jin Zhou, Yan Li, Katsuo Hatayama, Tatsuhiko Sano, Kensei Yoshikawa, Shohei Higuchi, Iwao Arai