Patents Assigned to Institute of Microchemical Technology
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Patent number: 8889071Abstract: An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.Type: GrantFiled: December 7, 2009Date of Patent: November 18, 2014Assignees: Institute of Microchemical Technology Co., Ltd., The University of TokyoInventors: Arata Aota, Takehiko Kitamori
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Patent number: 8815604Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.Type: GrantFiled: March 31, 2010Date of Patent: August 26, 2014Assignees: Institute of Microchemical Technology Co., Ltd., The University of Tokyo, Kanagawa Academy of Science and TechnologyInventors: Arata Aota, Yuko Kihira, Mari Sasaki, Takehiko Kitamori, Kazuma Mawatari
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Patent number: 8802449Abstract: An objective of the present invention is to provide immunoassay microchips in which microstructures of beads having a sufficient reaction area were constructed within microchannels while suppressing flow path resistance, and to provide simple and highly-sensitive immunoassay methods for microsamples. The objective was achieved by immunoassay microchips comprising microchannels with microstructures arranged in at least a portion of the microchannels, the microstructures retaining microbeads uniformly dispersed in photo-cured hydrophilic resins, and the microbeads having a primary antibody immobilized on their surfaces, and by immunoassay methods using the microchips.Type: GrantFiled: December 25, 2006Date of Patent: August 12, 2014Assignees: Institute of Microchemical Technology, Kansai Paint Co., Ltd.Inventors: Masaya Kakuta, Manabu Tokeshi, Hitoshi Izumida, Takahide Takadera, Kenji Miyagawa
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Patent number: 8329454Abstract: A device for detecting a cholinesterase-inhibiting substance comprising a basal layer fixed at the bottom of a container, and a cholinesterase-containing reaction layer which is fixed on the basal layer, wherein the basal layer and the cholinesterase-containing reaction layer comprises a hydrophilic photo-crosslinkable resin.Type: GrantFiled: April 23, 2009Date of Patent: December 11, 2012Assignees: Institute of Microchemical Technology Co., Ltd., Kansai Paint Co., Ltd.Inventors: Hidekatsu Tazawa, Tomohiko Ebata, Takahide Takadera, Naonori Miyata
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Publication number: 20120177537Abstract: An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.Type: ApplicationFiled: December 7, 2009Publication date: July 12, 2012Applicants: THE UNIVERSITY OF TOKYO, INSTITUTE OF MICROCHEMICAL TECHNOLOGY CO., LTD.Inventors: Arata Aota, Takehiko Kitamori
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Publication number: 20120164743Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.Type: ApplicationFiled: March 31, 2010Publication date: June 28, 2012Applicants: INSTITUTE OF MICROCHEMICAL TECHNOLOGY CO., LTD., KANAGAWA ACADEMY OF SCIENCE AND TECHNOLOGY, THE UNIVERSITY OF TOKYOInventors: Arata Aota, Yuko Kihira, Mari Sasaki, Takehiko Kitamori, Kazuma Mawatari
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Publication number: 20100060981Abstract: An objective of the present invention is to provide a circular dichroism thermal lens microscope apparatus capable of identifying and quantifying optically active samples in ultra-trace amounts, and which has a higher sensitivity than conventional apparatuses. The objective is achieved by a circular dichroism thermal lens microscope apparatus which beams excitation light and detection light into an optical microscope, where the detection light enters a thermal lens formed by irradiating a sample with the excitation light, and a substance in a sample is detected by determining the diffusion of the detection light by the thermal lens, and where the excitation light is modulated by a phase-modulation element, so as to identify or quantify an optical isomer.Type: ApplicationFiled: February 10, 2006Publication date: March 11, 2010Applicants: Kanagawa Academy of Science and Technology, Institute of Microchemical Technology, The University of TokyoInventors: Masayo Yamauchi, Akihide Hibara, Takehiko Kitamori, Kazuma Mawatari, Manabu Tokeshi