Abstract: An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.
Type:
Grant
Filed:
December 7, 2009
Date of Patent:
November 18, 2014
Assignees:
Institute of Microchemical Technology Co., Ltd., The University of Tokyo
Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.
Type:
Grant
Filed:
March 31, 2010
Date of Patent:
August 26, 2014
Assignees:
Institute of Microchemical Technology Co., Ltd., The University of Tokyo, Kanagawa Academy of Science and Technology
Abstract: A device for detecting a cholinesterase-inhibiting substance comprising a basal layer fixed at the bottom of a container, and a cholinesterase-containing reaction layer which is fixed on the basal layer, wherein the basal layer and the cholinesterase-containing reaction layer comprises a hydrophilic photo-crosslinkable resin.
Type:
Grant
Filed:
April 23, 2009
Date of Patent:
December 11, 2012
Assignees:
Institute of Microchemical Technology Co., Ltd., Kansai Paint Co., Ltd.
Abstract: An apparatus for separating plasma by which plasma can be separated from a small amount of whole blood cell sample without centrifugation is disclosed. This apparatus includes a blood channel through which blood flows; and a plasma channel through which plasma separated from said blood flows. The plasma channel is arranged at least partially in parallel with said blood channel and the blood channel and the plasma channel are at least partially in contact with each other along the longitudinal direction of the channels. Blood is made to flow at a flow rate at which blood cell components in the blood flowing through the blood channel axially accumulate and at which hemolysis does not occur. The plasma moves to the plasma channel after being separated into a blood cell layer and a plasma layer.
Type:
Application
Filed:
December 7, 2009
Publication date:
July 12, 2012
Applicants:
THE UNIVERSITY OF TOKYO, INSTITUTE OF MICROCHEMICAL TECHNOLOGY CO., LTD.
Abstract: A microchannel chip having a microchannel formed in a substrate and a gas-liquid phase separation microchannel whose upper part is covered with a porous film, the gas-liquid phase separation microchannel being connected to the downstream end of the microchannel and having a depth of 10 ?m to 100 ?m. Also, a gas-liquid phase separation method which is a method for separating a liquid-phase flow from a two-phase flow flowing through a microchannel by removing a gas phase, the two-phase flow composed of the gas phase and the liquid phase, which liquid phase flows in the periphery of the above-described microchannel and which gas phase flows interiorly of the liquid-phase flow.
Type:
Application
Filed:
March 31, 2010
Publication date:
June 28, 2012
Applicants:
INSTITUTE OF MICROCHEMICAL TECHNOLOGY CO., LTD., KANAGAWA ACADEMY OF SCIENCE AND TECHNOLOGY, THE UNIVERSITY OF TOKYO