Patents Assigned to INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY
  • Publication number: 20240123096
    Abstract: A F-18 positron diagnostic contrast agent precursor, the F-18 positron diagnostic contrast agent prepared using the F-18 positron diagnostic contrast agent precursor can be used for positron emission tomography to detect type II vesicular monoamine transporter, produce no metabolites similar to F-18-propanol because the F-18 is marked on the aromatic ring, and can reduce the background value of normal organs while using.
    Type: Application
    Filed: September 29, 2022
    Publication date: April 18, 2024
    Applicant: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
    Inventor: Yu CHANG
  • Patent number: 11951091
    Abstract: Disclosed herein is a complex, a contrast agent and the method for treating a disease related to CXCR4 receptor. The complex is configured to bind the CXCR4 receptor, and is used as a medicament for diagnosis and treatment of cancers and other indications related to the CXCR4 receptor.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: April 9, 2024
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Chien-Chung Hsia, Chung-Hsin Yeh, Cheng-Liang Peng, Chun-Tang Chen
  • Patent number: 11897172
    Abstract: A polar plate is fabricated. The polar plate is flexible and made of a plastic graphite composite. No matter a supporting member is used for calendering or not, a thin polar plate with controllable thickness is fabricated. The polar plate is excellent in blocking the through-transmission of vanadium ions and the limit of blending ratio of conductive carbon is broken through. The longitudinal through-transmission volume resistivity (proportional resistance to thickness) is greatly improved by adjusting the blending ratio of conductive carbon for meeting the demand of conductivity. In the mean time, the present invention strengthens the rigidity required for the thin polar plate while providing large-area polar plate fabrication for industrial use and convenience and provides a cooling and pressing method for patterning a composite polar plate. An integrated mold is thus obtained to replace the conventional polar plate which needs to be processed and prepared with runner.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: February 13, 2024
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Hung-Hsien Ku, Ning-Yih Hsu, Han-Jou Lin, Tai-Feng Hung, Qiao-Ya Chen
  • Publication number: 20240024518
    Abstract: The present invention provides a contrast agent which is efficiently and specifically absorbed by tumor cells, suitable for use in single photon emission computed tomography for the diagnosis, efficacy assessment and tumor tracking of neuroblastoma, pheochromocytoma or congestive heart failure.
    Type: Application
    Filed: January 19, 2023
    Publication date: January 25, 2024
    Applicant: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
    Inventors: Shiu-Wen LIU, Yi-Jhih CHEN, Wei-Hsi CHEN, Yu CHANG, Cheng-Fang HSU
  • Patent number: 11830986
    Abstract: A quantum battery manufacturing method includes: providing a p-type semiconductor substrate including a first conductive substrate and a p-type semiconductor layer disposed on one surface of the first conductive substrate; providing an n-type semiconductor substrate including a second conductive substrate and an n-type semiconductor layer disposed on one surface of the second conductive substrate; and forming an electricity storage layer between the p-type semiconductor substrate and the n-type semiconductor substrate, and attaching two sides of the electricity storage layer respectively to the p-type semiconductor layer and the n-type semiconductor layer to form a quantum battery. The electricity storage layer is formed by heating a thermoplastic polymer to soften and become a liquid, mixing the liquid with energized core-shell particles, and coating a substrate with the mixture. Core-shell particles are disposed on a conductive substrate and irradiated with ultraviolet rays for energization.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: November 28, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Min-Chuan Wang, Bo-Hsien Wu, Shang-En Liu
  • Patent number: 11817556
    Abstract: A composite gel polymer electrolyte lithium battery structure includes a positive electrode, a negative electrode and an electrolyte film component. The electrolyte film component, disposed between the positive electrode and the negative electrode, includes a separator and at least one electrolyte film. The at least one electrolyte film is at least consisted of sulfolane and/or propylene carbonate (PC), a lithium salt material, a solid-state polymer material and fire-retardant additives. In addition, a method for fabricating the composite gel polymer electrolyte lithium battery structure is also provided.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: November 14, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Shang-En Liu, Tien-Hsiang Hsueh, Min-Chuan Wang
  • Publication number: 20230346987
    Abstract: Structural design of cranial nerve degeneration contrast agent precursor, the cranial nerve degeneration contrast agent prepared using the cranial nerve degeneration contrast agent precursor can be used for positron radiation tomography to detect alpha-synuclein.
    Type: Application
    Filed: September 13, 2022
    Publication date: November 2, 2023
    Applicant: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
    Inventors: Shiou-Shiow FARN, Hung-Wen YU, Kuan-Yin CHEN, Tsung-Yu SHIH, Yun-Sheng LIN
  • Patent number: 11739076
    Abstract: The present disclosure relates to a compound or its salt thereof targeting fibroblast activation protein, its preparation methods and uses, especially the compound represented by formula (I) D-R1-R2-A-R? or its salt thereof, and its preparation methods and its uses.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: August 29, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, R.O.C.
    Inventors: Ming-Hsin Li, Sheng-Nan Lo, Shih-Ying Lee, Su-Jung Chen, Shih-Wei Lo, Wei-Lin Lo, Ming-Wei Chen
  • Patent number: 11693146
    Abstract: A calculation method for a dual-energy X-ray imaging system is provided. The calculation method for the dual-energy X-ray imaging system includes the following steps. A plurality of material attenuation coefficient ratio of the dual-energy projection image are established according to the reference materials with known material characteristics. The effective atomic number of each reference material and the material attenuation coefficient ratio are used to establish a calibration data set. A rational polynomial approximation method is adopted to obtain the characteristic model related to the material attenuation coefficient ratio of the reference material and the effective atomic number of the reference material. The material attenuation coefficient ratio of the dual-energy projection image of unknown material is established.
    Type: Grant
    Filed: January 12, 2022
    Date of Patent: July 4, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Chia-Hao Chang, Yu-Ching Ni, Sheng-Pin Tseng
  • Patent number: 11681054
    Abstract: A position-signal processing method for flat panel gamma imaging probe includes a modeling phase and a use phase. In the modeling phase, a weight direction for an imaging detector is defined, position centers and weight ratios of the imaging detector in the weight direction are utilized to obtain a distribution graph of the weight ratios to the position centers, and curve fitting is performed upon the distribution graph to obtain a position estimation curve. In the use phase, the position estimation curve is utilized to derive a position estimation value of a probe trigger event in a 2D crystal diagram, a position value of the probe in the 2D crystal diagram with respect to the position estimation value of the probe trigger event is obtained, and a crystal code is located in a crystal code look-up table for the position value of the probe in the 2D crystal diagram.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: June 20, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Hsin-Chin Liang, Chen-Han Cheng
  • Patent number: 11654203
    Abstract: Disclosed herein are a dual-targeted carbonic anhydrase IX complex, a contrast agent comprising the same, and a synthesizing method thereof. The dual-targeted carbonic anhydrase IX complex includes a carbonic anhydrase IX (CA9) binding peptide, a sulfonamide derivative, and a metal chelating agent. The dual-targeted carbonic anhydrase IX complex has potential for use as a molecular nuclear drug.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: May 23, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Siao-Syun Guan, Tsai-Yueh Luo, Tse-Zung Liao, Cheng-Liang Peng, Kun-Liang Lin
  • Patent number: 11658341
    Abstract: A method for manufacturing a gel-state flame-retardant electrolyte film includes the steps of: preparing a first solution having a high boiling-point solvent; adding a solid-state polymer material into the first solution, and performing a heating and stirring process to form a second solution; adding a flame-retardant electrolyte material and a flame-retardant water-absorbent material into the second solution for forming a third solution by well mixing; forming the third solution into a viscous matter; and, solidifying the viscous matter to form the gel-state flame-retardant electrolyte film. In addition, a gel-state flame-retardant electrolyte film, a gel-state electrolyte battery and a method for manufacturing the gel-state electrolyte battery are also provided.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: May 23, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Tien-Hsiang Hsueh, Shang-En Liu, Min-Chuan Wang, Bo-Hsien Wu, Shu-Mei Chang
  • Patent number: 11630219
    Abstract: A pressure-regulating large-area windowless airflow proportional counter is provided, which includes a chamber, a metal tray, a side cover, a gas cylinder, and a voltage input and signal output terminal. The chamber has a side opening. A large-area source is placed on the metal tray and the metal tray is moved into or out of the chamber via the side opening. The side cover is fixed to the side opening by an O-ring via a locking device to form an airtight structure. The gas cylinder is used to supply a dedicated gas into the chamber. The voltage-input/signal-output terminal is used to supply voltage to an anode wire net. The free electrons generated by the large-area source due to the free phenomenon are collected by the anode wire net, and outputted to a voltage signal processing module through the voltage-input/signal-output terminal for analysis of pulse height or pulse count.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: April 18, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Chin-Chi Chen, Ming-Chen Yuan
  • Patent number: 11466002
    Abstract: This invention discloses method for preparing a non-radioactive standard ?-CFT. Using cocaine hydrochloride as the starting material, and after a series of hydrolysis, dehydration, esterification and bonding reactions, a non-radioactive standard (2?-Carbomethoxy-3?-(4-fluoropenyl) tropane) is prepared. Furthermore, this preparation method has fewer steps, is easy to operate, and the purity of the product is as high as 97.97%. Therefore, the method for preparing a non-radioactive standard ?-CFT can promote the development of positron imaging in the diagnosis of Parkinson's disease.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: October 11, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Ching Yun Lee, Yu Chang
  • Patent number: 11369702
    Abstract: Disclosed herein are kits and methods for preparing radiopharmaceuticals. The kits and methods of the present disclosure can prepare the radiopharmaceuticals without using a heater and computer monitoring equipment. The kit includes a frozen crystal reaction vial, a reagent vial and a labeling holder, wherein the labeling holder contains a heating bag that can heat up to a high temperature of at least 95° C. by adding an aqueous solution.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: June 28, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Ming-Hsin Li, Shih-Wei Lo, Sheng-Nan Lo, Shih-Ying Lee, Su-Jung Chen
  • Patent number: 11369268
    Abstract: A brain-function image data augmentation method includes: a step of providing a target database including a plurality of image-data information; a step of, based on a plurality of image-data expected information in an expectation-value database, calculating a ratio of the plurality of image-data expected information with respect to different ages; a step of, based on the plurality of image-data information and the ratio, obtaining image-data ratio information with respect to an estimated age; a step of establishing a relationship for each pair of the image-data information and the image-data expected information; a step of, based on the relationship, the ratio and the image-data information, calculating an estimated image-data information with respect to the estimated age; and, a step of combining linearly the estimated image-data information and the image-data ratio information so as to generate an augmented image-data information with respect to the estimated age.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: June 28, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Fan-Pin Tseng, Yu-Ching Ni, Wen-Bin Lin
  • Patent number: 11370701
    Abstract: A solar control film with improved moisture resistance function is provided. The solar control film includes a flexible substrate, at least one infrared-reflective composite layer and an outer dielectric layer. The infrared-reflective composite layer includes a dielectric sublayer and a metal sublayer. The dielectric sublayer is disposed on the flexible substrate, and the material of the dielectric sublayer includes TiO2. The metal sublayer is disposed on the dielectric sublayer, and includes 8.3-16.4 atomic % Ag, 0.5-1.0 atomic % Ti, 81.0-90.9 atomic % N, and 0.3-0.6 atomic % noble metal, and the noble metal is Au, Pd or any combinations thereof. The outer dielectric layer is disposed on the infrared-reflective composite layer, and the material of the outer dielectric layer includes TiO2. In this way, the provided solar control film can effectively suppress of forming white spots without significantly sacrificing its original function and characteristics.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: June 28, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan
    Inventors: Yung-Ching Liu, En-Shih Chen, Cheng-Chang Hsieh
  • Patent number: 11349135
    Abstract: A method of preparation and application for a glass ceramic sealing thin strip with high sealing performance, differing from using conventional glass ceramic packaging paste applied to the junction of the cell stack assembly and connecting plates. The glass ceramic sealing thin strip of present invention utilizes tape casting to produce a single layer or multi-layer stacking in accordance with the required thickness of the glass-ceramic sealing thin strip, and cutting the glass ceramic sealing thin strips from molds in accordance with the geometry of cell stacks with equal thickness of the glass ceramic sealing thin strip for SOFC cell stack assembly, aiming to overcome the setbacks of the conventional dispensing method with glass ceramic packaging paste that makes the thickness difficult to control, and to effectively improve sealing performance of the cell stack assembly and the power generation efficiency, and achieve commercial application with mass production.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: May 31, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
    Inventors: Tai-Nan Lin, Szu-Han Wu, Yi-Jing Wu, Min-Fang Han, Wei-Xin Kao, Hong-Yi Kuo, Chun-Yen Yeh, Yung-Neng Cheng, Ruey-Yi Lee
  • Patent number: 11327117
    Abstract: An apparatus is provided for measuring the power of electrolytes at different positions of a flow battery by switching six-way valves without reconnecting channels. With the measurements at the positions, weighting is processed to obtain power corresponding to charging statuses for determining accurate power. The charging and discharging of voltage and current of the battery are controlled for constant operations with high efficiency. Consequently, the efficiency of power conversion is improved; energy consumption is reduced; and the battery is always run within a safe power-range for avoiding accidents or damages to the battery. In addition, the present invention is further applicable to a device monitoring the features of a battery unit. The six-way valves online monitor the power at center positions by switching. The values measured at different positions are aimed at the abnormality of the battery unit for processing adjustment or offline replacement to maintain best operation performance.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: May 10, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Hung-Hsien Ku, Ning-Yih Hsu, Chin-Lung Hsieh, Yi-Hsin Hu, Qiao-Ya Chen
  • Patent number: 11311261
    Abstract: A nuclear image processing method is provided. The method includes the following steps: inputting a normalized standard space nuclear image; selecting a voxel of the normalized standard space nuclear image and collecting the values of the neighbor voxels to form a voxel value set; conducting a data augmentation algorithm to generate a voxel distribution function; calculating an expected value of the distribution and calculating a first standard deviation of the portion over the expected value and a second standard deviation of the portion lower than the expected value; repeating the above steps to calculate the expected value, the first standard deviation and the second standard deviation of the necessary voxels, so as to form an image standardization template set including expected value template, first standard deviation template and the second standard deviation template.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: April 26, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
    Inventors: Ho-Hui Hsieh, Yu-Ching Ni