Abstract: A novel method of preparation of easily stripped off temporary wound dressing material is disclosed. In this process, the-N-isopropyl acrylamide (NIPAAm) monomer is successfully grafted on the non-woven cloths by copolymerization. It is initiated by .gamma.-ray irradiation to activate the surface of the non-woven cloth. NIPAAm is then grafted onto the surface of the non-woven cloth. The free radical or peroxide is produced by Co-60 .gamma.-ray, then grafted on the non-woven cloths. The lower critical solution temperature (LCST) in thermoresponsive poly-N-isopropylacrylamide (NIPAAm) is still retained after the grafting. This will make the dressing cloth stripped off easily and without hurting the tissue. The material process is very simple and has medically applicable value.
Type:
Grant
Filed:
June 23, 1997
Date of Patent:
February 8, 2000
Assignee:
Institute of Nuclear Energy Research, Taiwan, R.O.C.
Inventors:
Chia-Chieh Chen, Ko-Shao Chen, Te-Hsing Wu, Ching-Hohn Len, Zei-Tsan Tsai, Bin Lin
Abstract: Novel tumor imaging agents in which the dimercaptosuccinic acid was dissolved in phosphate buffer and labelled with radioisotope gallium. The product of gallium dimercaptosuccinate has been characterized by a variety of experiments including serum stability, biodistribution and imaging experiment. As the results, the compound of gallium dimercaptosuccinate has been confirmed as a novel radiopharmaceutical for tumor imaging agent.
Type:
Grant
Filed:
December 15, 1994
Date of Patent:
June 17, 1997
Assignee:
Institute of Nuclear Energy Research, Taiwan