Patents Assigned to Institute of Nuclear Energy
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Patent number: 10117956Abstract: The present invention is related to a radiolabeled active targeting pharmaceutical composition, including: a bioconjugate and a radionuclide, wherein the bioconjugate includes a biomolecule and a metal nanoparticle, wherein the biomolecule has an affinity for receptors on the surface of a cell membrane and is selected from the group consisting of a peptide and a protein. The present invention further provides a method for evaluating a thermal adjuvant therapy for tumors and a kit thereof. The above-mentioned pharmaceutical composition is applied to evaluate a tumor accumulation time, so as to establish the optimal policy for a radiofrequency- or laser-induced thermal adjuvant therapy for tumors.Type: GrantFiled: September 14, 2017Date of Patent: November 6, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUANInventors: Hsin-Ell Wang, Chien-Chung Hsia, Mao-Chi Weng, Kun-Liang Lin, Hao-Wen Kao, Chao-Cheng Chen, Kwan-Hwa Chi, Der-Chi Tien, Wuu-Jyh Lin
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Patent number: 10110164Abstract: The present invention discloses a concentrator photovoltaic module and the alignment device and method thereof. A laser source is disposed on a top surface of an alignment device at a tilt angle. According to the optical alignment points on a circuit board, the circuit board and the concentrating lens can be aligned and thus completing assembling a concentrator photovoltaic module. The alignment device and method for concentrator photovoltaic module requires no optically inactive region to complete alignment. Thereby, the utilization of the sunlight and the output power efficiency of the concentrator photovoltaic module can be enhanced.Type: GrantFiled: September 29, 2016Date of Patent: October 23, 2018Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.Inventors: Chun-Yi Chen, Yueh-Mu Lee, Zun-Hao Shih, Yi-Ya Huang, Hwen-Fen Hong
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Patent number: 10085943Abstract: Disclosed herein are a novel polymer, a thermosensitive carrier prepared using the same and use thereof. The novel polymer is essentially composed of a PEO-PPO-PEO block copolymer and silane.Type: GrantFiled: September 19, 2016Date of Patent: October 2, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.Inventors: Po-Jung Chen, Mao-Chi Weng, Mei-Hui Wang, Chien-Chung Hsia
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Patent number: 10090804Abstract: The present invention discloses a concentrator photovoltaic module and the alignment device and method thereof. A laser source is disposed on a top surface of an alignment device at a tilt angle. According to the optical alignment points on a circuit board, the circuit board and the concentrating lens can be aligned and thus completing assembling a concentrator photovoltaic module. The alignment device and method for concentrator photovoltaic module requires no optically inactive region to complete alignment. Thereby, the utilization of the sunlight and the output power efficiency of the concentrator photovoltaic module can be enhanced.Type: GrantFiled: January 9, 2018Date of Patent: October 2, 2018Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive YuanInventors: Chun-Yi Chen, Yueh-Mu Lee, Zun-Hao Shih, Yi-Ya Huang, Hwen-Fen Hong
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Patent number: 10081653Abstract: The present invention provides a method for preparing a 6-aminohexyl lactoside-NOTA conjugate. The preparation method comprises brominating perbenzoylated lactose with hydrobromic acid; glycosylating 6-azidohexanol to obtain 6-azidohexyl perbenzoyl lactoside; and deprotecting this precursor in two steps to obtain 6-aminohexyl lactoside and conjugating 6-aminohexyl lactoside to NCS-benzyl-NODA GA (i.e. 2,2?-(7-(1-carboxy-4-((4-isothiocyanate benzyl) amino)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl) diacetic acid) in triethyl amine as an alkaline solvent, to obtain a 6-aminohexyl lactoside-NCS-benzyl-NODA GA conjugate. In this novel preparation method, no deglycosylated side product is produced, such that the yield is considerably increased to 46%. Therefore, the method is suitable for future massive production since the requirement for repeated preparations for massive production is reduced, and the impurities produced in the previously scaled-up preparation process are not present.Type: GrantFiled: July 20, 2016Date of Patent: September 25, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.CInventors: Rui-Yu Chen, Yan-Feng Jiang, Mei-Hui Wang, Jen-Tsung Wang, Wuu-Jyh Lin
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Patent number: 10083529Abstract: A reduction method for a boundary artifact on the tomosynthesis includes steps of performing a projection process, performing a back projection process upon the geometric factor matrix so as to obtain a back-projection geometric factor matrix, and adjusting a boundary area of the back-projection geometric factor matrix.Type: GrantFiled: June 9, 2017Date of Patent: September 25, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.Inventors: Fan-Pin Tseng, Chia-Yu Lin
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Patent number: 10040207Abstract: The present invention is a novel passive adjustable gravity compensation apparatus which utilizes an internal-pressure-variable cylinder. With the coordination of cam, rod, or the combination of the fore mentioned, the internal-pressure-variable cylinder obtains the characteristics of a linear elastic device which has variable elastic coefficient. Through appropriately adjusting the internal pressure of the internal-pressure-variable cylinder, the cylinder would perform as a linear elastic device with proper elastic coefficient to fully or partially compensate the gravitational effect of the manipulator system and the load it holds. Thus, the proposed invention can fully or partially compensate the gravitational effect of the manipulator system at different loading conditions without changing its geometric configuration.Type: GrantFiled: September 18, 2017Date of Patent: August 7, 2018Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.Inventor: Kuei-Jen Cheng
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Patent number: 10022706Abstract: A composite material type oxygen transport membrane and its preparation method are disclosed. The composite material that is an ionic-electronic mixed conducting material having high ionic conductivity is stirred into slurry and formed into a thin strip-shaped green tape substrate through tape casting to obtain a predetermined half-finished substrate, and then sintered to form the half-finished substrate into a conductive function type oxygen ion conducting substrate, followed by choosing small particle shaped highly catalyzed ionic-electronic mixed conducting material to be evenly adhered to at least one side surface of the conductive function type oxygen ion conducting substrate to form a reductive function type oxygen ion conducting layer. The reductive function type oxygen ion conducting layer and the conductive function type oxygen ion conducting substrate are then bonded to produce a composite material type oxygen transport membrane element.Type: GrantFiled: April 20, 2017Date of Patent: July 17, 2018Assignee: Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: Ming-Wei Liao, Tai-Nan Lin, Wei-Xin Kao, Chun-Yen Yeh, Hong-Yi Kuo, Yu-Ming Chen
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Patent number: 10017897Abstract: A method is provided to enhance efficiency of carbon felts in a flow battery. The carbon felts are directly immersed in a mixed acid solution. The carbon felts with the solution are heated at a low temperature and processed through sonication. On surface defects of the carbon felts, —OH and C?O functional groups are efficiently generated. The functional groups catalyze the redox reaction of vanadium ions. More active positions are obtained on the carbon felts through the activation treatment. Both of valence exchange and redox velocity of the vanadium ions are enhanced. Thus, the present invention has simple and fast processes with easily regulated experimental parameters for good modification without high temperature treatment but low cost.Type: GrantFiled: January 3, 2017Date of Patent: July 10, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.Inventors: Yi-Sin Chou, Heng-Wei Chiang, Chao-Yen Kuo, Ning-Yih Hsu
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Patent number: 10020515Abstract: The present invention relates to a strontium magnesium molybdenum oxide material having perovskite structure and the method for preparing the same. Citric acid is adopted as the chelating agent. By using sol-gel pyrolysis and replacing a portion of strontium in Sr2MgMoO6-? by cerium and a portion of magnesium by copper, a material with a chemical formula of Sr2-xCexMg1-yCuyMoO6-? is produced, where 0?x<2, 0<y<1, and 0<?<6. Thereby, the electrical conductivity of the material is improved. The perovskite-type cerium- and copper-replaced strontium magnesium molybdenum oxide significantly increases the electrical conductivity of the material and can be applied as the anode material for solid oxide fuel cell (SOFC).Type: GrantFiled: July 14, 2016Date of Patent: July 10, 2018Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.Inventors: Tsui-Yun Chung, Chien-Kuo Liu, Jing-Kai Lin, Hui-Ping Tseng, Ruey-Yi Lee
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Patent number: 10016170Abstract: The invention provides a loading mechanism for x-ray tube. The loading mechanism for x-ray tube includes an x-ray tube, a swing element and a rotating element. The x-ray tube includes a focal spot location and an x-ray opening. The swing element includes a first rotating axis, and the first rotating axis passes through the focal spot location. The swing element rotates about the first axis to rotate the x-ray tube within a limit swing range. The rotating element is connected to the swing element. The rotating element has a second rotating axis, and the first rotating axis perpendicular to the second rotating axis. The rotating element rotates about the second rotating axis to drive rotate the x-ray tube and the swing element. In addition, the scanning system for three-dimensional image is provided.Type: GrantFiled: April 20, 2016Date of Patent: July 10, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.Inventors: Sheng-Pin Tseng, Ho-Hui Hsieh
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Patent number: 10010845Abstract: An apparatus of hydrocarbon fuel reactors separates and purifies carbon dioxide (CO2). Interconnected fluidized beds are applied in chemical-looping combustion. A multi-stage reduction reaction is processed with iron-based oxygen carriers. Three reduction stages using the iron-based oxygen carriers are accurately and completely controlled. Each of the three stages is separately processed in an individual space. Oxygen in the iron-based oxygen carriers can be fully released. High-purity CO2 is obtained. Hydrogen can be produced as an option. Horizontal connection of three reduction reactors is changed into vertical one. An oxidation reactor is further connected. Thus, the whole structure occupies less area and effectively uses vertical space. Not only small space is effectively used; but also high-volume capacity is obtained. Each of the reactors has better geometry flexibility. The tandem reactor in each layer has less geometric influence and limitation.Type: GrantFiled: October 27, 2016Date of Patent: July 3, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.Inventors: Yau-Pin Chyou, Po-Chuang Chen, Hsiu-Yun Chien, Keng-Tung Wu, Ching-Ying Huang
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Patent number: 10005727Abstract: The present invention relates to a group of compounds for nuclear medicine imaging through F-18 labeled histone acetylation inhibitors (HDACi) of indole or indoline benzoyl amine and its derivatives, and provides a series of nuclear medicine imaging agents that bind with HDAC overexpression in vivo for diagnosis of malignant tumors discovered in the nuclear medicine imaging tracing.Type: GrantFiled: October 6, 2016Date of Patent: June 26, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL EXECUTIVE YUANInventors: Ming-Hsin Li, Chyng-Yann Shiue, Han-Chih Chang, Chun-Fang Feng
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Patent number: 9981953Abstract: A contrast agent precursor is revealed. The contrast agent precursor includes a 1,4,7-Tris(carbonylmethyl)-1,4,7,10-tetraazacyclododecane that forms complexes with radioisotopes or connects to a peptide. The contrast agent precursor also includes a 2-nitroimidazole that allows the precursor to become retained in hypoxic tissues According to the features mentioned above, the contrast agent prepared by the precursor has a better binding specificity, labeling accuracy and detection sensitivity. Moreover, a method for preparing the contrast agent precursor not only solves the emulsion problem generated during conventional synthesis of intermediate products but also provides a solution to the problem of residual trifluoroacetic acid. Both the yield rate and the purity of the final product are also improved.Type: GrantFiled: January 4, 2017Date of Patent: May 29, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.Inventors: Wen-Ching Wu, Kuei-Lin Lu, Yu Chang, Cheng-Fang Hsu
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Patent number: 9981050Abstract: Disclosed herein is a bispecific peptide conjugate comprising an epidermal growth factor receptor (EGFR) targeting peptide, an ?v?3 integrin targeting peptide, and a linker, where the linker is conjugated respectively to the EGFR targeting peptide and the ?v?3 integrin targeting peptide.Type: GrantFiled: May 18, 2016Date of Patent: May 29, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.Inventors: Hung-Man Yu, Jyun-Hong Chen, Kun-Liang Lin, Chien-Jen Chen, Wuu-Jyh Lin
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Patent number: 9979032Abstract: A treatment method for solid oxide fuel cells includes: measuring a radius of curvature of a cell; measuring a surface resistance of cathode current collecting layer of a cell; performing an alcohol permeating test of a cell; performing simultaneously several stages of compression and heating or cooling to a cell; an apparatus for completing above stages is also disclosed.Type: GrantFiled: October 15, 2015Date of Patent: May 22, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUANInventors: Chang-Sing Hwang, Chun-Liang Chang, Chun-Huang Tsai, Sheng-Huei Nian, Chih-Ming Chuang, Shih-Wei Cheng
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Patent number: 9976929Abstract: An apparatus is provided to verify the integrity of the confinement boundary of a spent nuclear fuel dry storage canister in operation. An external-convection blocking device is used to temporarily isolate the dry storage system or the dry storage canister from the ambient environment to form an isolated space. A gas sampling-and-analyzing device is connected to the isolated space to measure the leak rate or concentration of helium or radioactive gases which release from the dry storage canister. After the leak rate or concentration of helium or radioactive gases is measured, the integrity of the confinement boundary of the dry storage canister can be verified to further enhance the safety of the spent nuclear fuel dry storage.Type: GrantFiled: October 20, 2015Date of Patent: May 22, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.Inventors: Ching-Wei Yang, Kuei-Jen Cheng, Yu-Tang Yang
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Patent number: 9960444Abstract: A semi-vanadium(V) redox flow battery (semi-VRFB) including a positive electrolyte tank, a negative electrolyte tank and a cell stack. The positive electrolyte tank is stored with a positive electrolyte of V ions and the negative electrolyte tank is stored with a negative electrolyte of iodine(I)-vitamin C. The cell stack comprises a positive electrode, a negative electrode, an insulating film, a positive electrode plate, and a negative electrode plate. The negative electrode is made of carbon (C) sandwiched with titanium dioxide(TiO2), and can further comprise a metal or an alloy. The insulating film is located between the positive electrode and the negative electrode. The positive and negative electrode plates are located in front of the positive and negative electrodes, respectively. The positive and negative electrolytes flow through the positive and negative electrode plates to charge/discharge power by the electrochemical reactions of V ions and I-vitamin C at the positive and negative electrodes.Type: GrantFiled: June 17, 2015Date of Patent: May 1, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.Inventors: Chin-Lung Hsieh, Shu-Ling Huang, Tz-Jiun Tsai, Ming-Wei Hsueh, Mei-Ling Chen
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Patent number: 9953461Abstract: A navigation system includes a measurement unit that outputs a positioning signal associated with positioning coordinates, a navigation unit that obtains guidance indication and that outputs a navigation signal, and an image unit that includes a capturing module capturing a series of planar images, a computation module and an augmented reality module. The computation module generates an optical flow signal for obtaining the positioning coordinates, and further outputs a registration signal. The augmented reality module performs image registration processing based on the navigation signal and the registration signal, so that the guidance indication is superimposed on the series of planar images of real-world scene for subsequent display.Type: GrantFiled: September 6, 2016Date of Patent: April 24, 2018Assignees: Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan, National Yunlin University of Science & TechnologyInventors: Chung-Hao Huang, Lun-Hui Lee, Chian-Cheng Ho, Bo-Kai Wang
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Patent number: 9951416Abstract: A vacuum coating apparatus includes at least a chamber, an arc discharge plasma source, a feeding-reeling unit, and a roller set. The first and second openings are connecting with the feeding or reeling unit so as to allow the substrate to enter and leave the chamber therethrough, respectively. The arc discharge plasma source located inside the chamber generates the plasma, which discharges radially from the arc discharge plasma source as its center. The roller set includes a plurality of the first rollers, which are located in the chamber and enclosing the arc discharge plasma source. A first surface of the substrate is facing the plurality of the first rollers and contacts tightly on the periphery of the first rollers so that the first rollers can rotate by the moving of the substrate. The material evaporated and emitted by the plasma is attached onto the first surface of the substrate.Type: GrantFiled: August 7, 2015Date of Patent: April 24, 2018Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUANInventors: Cheng-Chang Hsieh, Deng-Lian Lin, En-Shih Chen, Wen-Fa Tsai, Chi-Fong Ai