Patents Assigned to Institute of Organic Chemistry and Biochemistry ASCR, V.V.I.
  • Patent number: 10966999
    Abstract: Provided herein are the 3?3? cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 6, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • Patent number: 10294262
    Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: May 21, 2019
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • Patent number: 9624257
    Abstract: The invention provides compounds of formula I: wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: April 18, 2017
    Assignee: Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • Patent number: 9586986
    Abstract: Compounds of Formula I and a pharmaceutically acceptable salt thereof, an optical isomer thereof, or a mixture of optical isomers thereof, as well as compositions which include such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: March 7, 2017
    Assignees: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I., PALACKY UNIVERSITY IN OLOMOUC
    Inventors: Michal Hocek, Petr Naus, Olga Caletkova, Marian Hajduch, Petr Dzubak
  • Publication number: 20160159844
    Abstract: Compounds of Formula I and a pharmaceutically acceptable salt thereof, an optical isomer thereof, or a mixture of optical isomers thereof, as well as compositions which include such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 9, 2016
    Applicants: Institute of Organic Chemistry and Biochemistry ASCR, v.v.i., Palacky University in Olomouc
    Inventors: Michal HOCEK, Petr NAUS, Olga CALETKOVA, Marian HAJDUCH, Petr DZUBAK
  • Patent number: 9200020
    Abstract: The invention relates to compounds which are useful as inhibitors of 6-oxopurine phosphoribosyltransferases such as hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)PRT).
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: December 1, 2015
    Assignees: THE UNIVERSITY OF QUEENSLAND, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: John De Jersey, Luke William Guddat, Dana Hockova, Dianne Therese Keough
  • Publication number: 20150218201
    Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 6, 2015
    Applicant: Institute of Organic Chemistry and Biochemistry ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • Patent number: 8093226
    Abstract: The invention provides compounds of formula I: wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: January 10, 2012
    Assignee: Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.
    Inventors: Michal Hocek, Petr Naus