Abstract: The present application relates to a lipopeptide for potently inhibiting HIV, a derivative thereof, or a pharmaceutical composition thereof, and use thereof. The lipopeptide is the following a) or b): a) a lipopeptide formed by linking a polypeptide having an antiviral activity to a lipophilic compound linked to the carboxyl-terminus of the polypeptide; or b) a lipopeptide formed by linking a polypeptide having an antiviral activity to a terminal protecting group and a lipophilic compound linked to the carboxyl-terminus of the polypeptide, wherein the terminal protecting group is an amino-terminal protecting group and/or a carboxyl-terminal protecting group, the polypeptide has a sequence of 28 amino acid residues, corresponding to amino acids at positions of 127-154 of the sequence of gp41 from HIV-1 strain HXB2.
Type:
Grant
Filed:
April 18, 2017
Date of Patent:
June 20, 2023
Assignees:
Shanxi Kangbao Biological Product Co., Ltd., Institute of Pathogen Biology, Chinese Academy of Medical Sciences
Abstract: The characterization of a new strain of human rhinovirus of genetic group C (HRV-C) as well as methods and kits for detecting the presence of HRV-C by PCR amplification are provided.
Type:
Grant
Filed:
April 16, 2009
Date of Patent:
April 29, 2014
Assignees:
Biomerieux, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing Children's Hospital Affiliated to Capital Medical University
Inventors:
Richard Gonzalez, Jianwei Wang, Zichun Xiang, Kunling Shen
Abstract: The characterization of a new strain of human rhinovirus of genetic group C(HRV-C) as well as methods and kits for detecting the presence of HRV-C by PCR amplification are provided.
Type:
Application
Filed:
April 16, 2009
Publication date:
May 12, 2011
Applicants:
BIOMERIEUX, INSTITUTE OF PATHOGEN BIOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES, BEIJING CHILDREN'S HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIVERSITY
Inventors:
Richard Gonzalez, Jianwei Wang, Zichun Xiang, Kunling Shen