Patents Assigned to Institute of Problems of Chemcial Physics RAS (IPCP RAS)
  • Water-soluble binuclear nitrosyl iron complexes with natural aliphatic thiolyls possessing cytotoxic, apoptotic and no-donor activity
    Patent number: 8067628
    Abstract: The present invention relates to water-soluble binuclear cationic nitrosyl iron complexes with natural aliphatic thiolyls of general formula [Fe2(SR)2(NO)4]SO4, wherein R is sulfur-containing aliphatic ligands of natural origin, preferably, cystamine or penicillamine, to a method for the preparation thereof, to use thereof as an anticancer agent, to an apoptosis inducer, to a pharmaceutical composition comprising said complexes in an effective amount, and to a kit useful for the treatment of cancer diseases.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: November 29, 2011
    Assignee: Institute of Problems of Chemcial Physics RAS (IPCP RAS)
    Inventors: Natalia Alexeevna Sanina, Konstantin Alexandrovich Lysenko, Olga Stepanovna Zhukova, Tatyana Nikolaevna Rudneva, Nina Sergeevna Emelianova, Sergei Mikhailovich Aldoshin