Abstract: Disclosed in the present disclosure are substances having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substances are the compounds having the structure of general formula (I) or the geometric isomers or pharmaceutical salts thereof. Through evaluation on tyrosine kinase inhibitory activity and related experiments, the present disclosure demonstrates that these compounds have a good tyrosine kinase inhibitory activity, and may inhibit a variety of tumor cells, and thus may be developed into drugs for preventing and treating tumor diseases, especially liver cancer, lung cancer and neuroblastoma.
Type:
Grant
Filed:
June 20, 2013
Date of Patent:
May 9, 2017
Assignee:
Institute of Radiation Medicine, China Academy of Military Medical Sciences Pla
Inventors:
Xiaoming Yang, Lin Wang, Changyan Li, Yiqun Zhan, Jing Liu, Teng Luo, Haiyan Yan, Shouguo Zhang, Wei Li, Xiaoxue Wen, Tao Peng, Lu Li
Abstract: Disclosed in the present disclosure are substances having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substances are the compounds having the structure of general formula (I) or the geometric isomers or pharmaceutical salts thereof. Through evaluation on tyrosine kinase inhibitory activity and related experiments, the present disclosure demonstrates that these compounds have a good tyrosine kinase inhibitory activity, and may inhibit a variety of tumor cells, and thus may be developed into drugs for preventing and treating tumor diseases, especially liver cancer, lung cancer and neuroblastoma.
Type:
Application
Filed:
June 20, 2013
Publication date:
June 2, 2016
Applicant:
INSTITUTE OF RADIATION MEDICINE, CHINA ACADEMY OF MILITARY MEDICAL SCIENCES PLA
Inventors:
Xiaoming Yang, Lin Wang, Changyan Li, Yiqun Zhan, Jing Liu, Teng Luo, Haiyan Yan, Shouguo Zhang, Wei Li, Xiaoxue Wen, Tao Peng, Lu Li