Patents Assigned to Institute of Rheological Functions of Food
  • Publication number: 20250011347
    Abstract: A compound represented by formula (I), its racemic form, or their salt, wherein X represents an oxygen atom, a nitrogen atom or a sulfur atom; R1 represents an unsaturated aliphatic hydrocarbon group; R2 represents a saturated or unsaturated aliphatic hydrocarbon group; and R3 represents choline, ethanolamine, inositol or serine.
    Type: Application
    Filed: August 22, 2022
    Publication date: January 9, 2025
    Applicants: Institute of Rheological Function of Food Co., Ltd., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Takehiko FUJINO, Shiro MAWATARI, Tatsuo OKAUCHI, Takuya HISAMITSU, Shamim NIWASE, Masanori HONSHO, Kinichi NAKASHIMA, Hideyuki NAKASHIMA
  • Patent number: 12060379
    Abstract: A compound presented by the general formula (1), its racemic form, or their salt thereof: wherein in general formula (1), X represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R1 represents R1a—Y—R1b, wherein R1a and R1b independently represent a saturated or unsaturated aliphatic hydrocarbon group, aromatic group, heterocyclic group, or a combination thereof, and Y represents an oxygen atom, nitrogen atom, sulfur atom, or carbon atom, R2 independently represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: August 13, 2024
    Assignee: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari, Toyoharu Yamashita, Mitsuru Kitamura, Tatsuo Okauchi, Shamim Hossain
  • Publication number: 20240156845
    Abstract: A composition for ameliorating periodontal tissue containing plasmalogen extracted from animal tissues such as shellfish, sea squirts and birds.
    Type: Application
    Filed: February 22, 2022
    Publication date: May 16, 2024
    Applicant: Institute of Rheological Function of Food Co., Ltd.
    Inventors: Takayoshi KAWAZOE, Kengo IWASAKI, Ryuhei KANDA, Takehiko FUJINO, Shiro MAWATARI, Shamim NIWASE
  • Publication number: 20230293415
    Abstract: A composition for ameliorating skin condition having a collagen production promoting effect, a composition for ameliorating skin resilience, a composition for ameliorating skin wrinkles, a composition for ameliorating skin sagging, and a composition for promoting collagen production.
    Type: Application
    Filed: June 28, 2021
    Publication date: September 21, 2023
    Applicant: Institute of Rheological Function of Food Co., Ltd.
    Inventors: Takehiko FUJINO, Shiro MAWATARI, Masanori HONSHO
  • Publication number: 20230248628
    Abstract: A composition having hair growth and/hair restoration effect that includes plasmalogen extracted from tissues of animal such as shellfish, sea squirt, and birds, and that can be used as external preparation or oral preparation.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 10, 2023
    Applicant: Institute of Rheological Function of Food Co., Ltd.
    Inventors: Takehiko FUJINO, Shiro MAWATARI, Masanori HONSHO
  • Publication number: 20230158050
    Abstract: It is a composition for enhancing immune function, or a composition for activating natural killer cells, comprising plasmalogen.
    Type: Application
    Filed: April 27, 2021
    Publication date: May 25, 2023
    Applicant: Institute of Rheological Function of Food Co., Ltd.
    Inventors: Takehiko FUJINO, Shiro MAWATARI, Shamim NIWASE, Minoru FUJINO, Hiromi NYUZUKI
  • Publication number: 20210238208
    Abstract: A compound presented by the following Chemical Formula 1, a racemic form, or a salt thereof: wherein, X represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom, R1 represents R1a—Y—R1b (wherein R1a and R1b each independently represent a saturated or unsaturated aliphatic hydrocarbon group, an aromatic group, a heterocyclic group, or a combination thereof, and Y represents an oxygen atom, a nitrogen atom, a sulfur atom, or a carbon atom), R2 represents a saturated or unsaturated aliphatic hydrocarbon group, and R3 represents choline, ethanolamine, inositol, or serine.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 5, 2021
    Applicant: Institute of Rheological Functions of Food
    Inventors: Takehiko FUJINO, Shiro MAWATARI, Toyoharu YAMASHITA, Mitsuru KITAMURA, Tatsuo OKAUCHI, Shamim HOSSAIN
  • Patent number: 10653708
    Abstract: The present invention relates to uses of ether phospholipids in treating and preventing various diseases, including, but not limited to, neurodegenerative or brain diseases such as Alzheimer's disease, cognitive impairment, brain fatigue, Parkinson disease, depression, anxiety disorder, insomnia and schizophrenia; metabolic syndrome such as diabetes and obesity; various infectious diseases such as viral diseases; diseases related to inflammation; heart diseases, and immune disorders. Preferably, the ether phospholipids are derived from extracting bivalves, which provides superior efficacies in treating and preventing the diseases.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 19, 2020
    Assignee: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari
  • Publication number: 20190242915
    Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.
    Type: Application
    Filed: April 16, 2019
    Publication date: August 8, 2019
    Applicant: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari
  • Patent number: 10324100
    Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: June 18, 2019
    Assignee: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari
  • Publication number: 20180360854
    Abstract: The present invention relates to uses of ether phospholipids in treating and preventing various diseases, including, but not limited to, neurodegenerative or brain diseases such as Alzheimer's disease, cognitive impairment, brain fatigue, Parkinson disease, depression, anxiety disorder, insomnia and schizophrenia; metabolic syndrome such as diabetes and obesity; various infectious diseases such as viral diseases; diseases related to inflammation; heart diseases, and immune disorders. Preferably, the ether phospholipids are derived from extracting bivalves, which provides superior efficacies in treating and preventing the diseases.
    Type: Application
    Filed: June 16, 2017
    Publication date: December 20, 2018
    Applicant: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari
  • Publication number: 20180327433
    Abstract: [PROBLEM TO BE SOLVED] It enables any superior ether phospholipids to the conventional ones and a method for producing the same in an easy manner on a massive scale, in light of effects of treating and improving brain diseases such as Alzheimer's disease, Parkinson disease, depression and schizophrenia, metabolic diseases such as diabetes, various infectious diseases, and immune disorders. [SOLUTION] Ether phospholipids are obtained from bivalve tissues such as clams and corbicula by extraction processing. The ether phospholipids exhibit significantly superior effects of the above as compared to the conventional ether phospholipids derived from chicken tissues.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 15, 2018
    Applicant: Institute of Rheological Functions of Food
    Inventors: Takehiko FUJINO, Shiro MAWATARI
  • Publication number: 20180284143
    Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.
    Type: Application
    Filed: April 4, 2017
    Publication date: October 4, 2018
    Applicant: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari
  • Patent number: 9974727
    Abstract: Provided is a novel hair growth and hair restoration material having excellent efficacy in hair growth and hair restoration for both men and women, even when the components thereof are at ultra-dilute concentrations; the hair growth and hair restoration material being characterized in containing a sterol glucopyranoside, preferably a cholesteryl glucopyranoside, represented by general formula (I). (In the formula, Z represents a sterol residue from which the hydroxyl group attached to the 3-position of a cyclopentanohydrophenanthrene ring has been removed.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: May 22, 2018
    Assignee: Institute of Rheological Function of Food Co., Ltd.
    Inventors: Takehiko Fujino, Osami Nada, Yoshitaka Nadachi, Gunki Funatsu
  • Publication number: 20180127680
    Abstract: [PROBLEM TO BE SOLVED] To provide a method for producing ether phospholipids of high purity by an easy process. [SOLUTION] This production method comprises: (A) a step of extracting total lipids from organisms with non-polar organic solvent and branched alcohol mixture; and (B) a step of reacting the total lipids obtained by the step (A) with phospholipase A1 to decompose mixed diacyl-glycerophospholipids. This makes it possible to produce plasmalogen-type glycerophospholipids or ether phospholipids of high purity by an easy process.
    Type: Application
    Filed: May 12, 2015
    Publication date: May 10, 2018
    Applicant: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari
  • Patent number: 8044177
    Abstract: The present invention provides a novel water-soluble keratin derivative and applications thereof. Water-soluble keratin produced by the alkali treatment of feathers, and modified keratin, gives the following useful materials: (1) a high energy wave absorber, (2) a luminescent substrate, (3) a material weatherproofness improver, (4) a water repellant, and (5) a foaming agent.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: October 25, 2011
    Assignees: Umeda Jimusho Ltd., Institute of Rheological Function of Food Co., Ltd., Asai Germanium Research Institute Co., Ltd.
    Inventors: Keiji Umeda, Yositaka Nadachi, Katsunobu Sakai, Yukitaka Nogami, Masahiko Sudo