Abstract: A superconducting composition of matter including overlapping first and second regions. The regions comprise unit cells of a solid, the first region comprises an electrical insulator or semiconductor, and the second region comprises a metallic electrical conductor. The second region extends through the solid and a subset of said second region comprise surface metal unit cells that are adjacent to at least one unit cell from the first region. The ratio of the number of said surface metal unit cells to the total number of unit cells in the second region being at least 20 percent.
Abstract: A method for operation of AOFP circuits includes accepting data arriving at any phase of a clock cycle, synchronizing the data to a known phase of a subsequent clock cycle, and providing the synchronized data to an AQFP circuit during the known phase of the subsequent clock cycle. The accepting and synchronizing of the data may be performed by a phase synchronizer and/or by a token-passing circuit. An asynchronous AOFP device includes at least one AQFP circuit and an activation phase synchronizer and/or token-passing circuit. The phase synchronizer may comprise a multiplexed array of QFP Buffers that samples each input phase of the clock cycle through a weak constant zero cell and outputs the logical OR of all input clock phases, propagating an input signal on any activation phase to a first phase output of the next activation cycle.
Abstract: Systems and devices for dynamic damping of vibrations are described. Traditional methods of vibration damping often involve trade-offs between stiffness and damping, potentially compromising structural integrity for increased damping. The performance of these damping techniques can also be influenced by the specific profile of the vibrational excitation, presenting challenges in ensuring consistent and reliable damping across different operating conditions. A tunable friction-damping device formed from concentric layers can overcome many of these limitations and presents methods for dynamic damping of vibrations as an alternative solution.
Abstract: Aspects of the disclosure relate to non-naturally occurring constructs for the activation of Shank3 gene expression, AAV vectors comprising the constructs, and gene therapy methods.
Abstract: The present invention discloses novel methods and uses thereof for producing molecular spatial maps of metastatic breast cancer (MBC) and ductal carcinoma in situ of the breast (DCIS). A specific list of genes are identified using single-cell RNA sequencing and single-nucleus RNA sequencing and are used for RNA visualization of MBC and DCIS tissue microenvironment. Unexpected subtypes of tumor cells are revealed, and methods for identifying molecular biomarkers for MBC in the bone and breast and DCIS are disclosed. Furthermore, methods for identifying therapeutic agents and uses thereof for treating MBC and DCIS as well as compositions thereof comprising such identified therapeutic agents are provided.
Type:
Grant
Filed:
January 22, 2021
Date of Patent:
December 10, 2024
Assignees:
The Broad Institute, Inc., Massachusetts Institute of Technology, Dana-Farber Cancer Institute, Inc.
Inventors:
Aviv Regev, Johanna Klughammer, Daniel Abravanel
Abstract: Provided is a fine bubble supply device and a fine bubble analyzing system capable of more stably supplying fine bubbles unstable in a liquid. A fine bubble generating device generates fine bubbles. A retention vessel stores a liquid therein, and an inlet pipe and an outlet pipe of the fine bubbles are connected to the retention vessel. The fine bubbles generated from the fine bubble generating device are introduced into the liquid in the retention vessel through the inlet pipe to be retained in the liquid. The fine bubbles retained in the liquid are led out to a supply destination (fine bubble characteristic evaluation device) through the outlet pipe.
Type:
Grant
Filed:
March 15, 2019
Date of Patent:
December 10, 2024
Assignees:
SHIMADZU CORPORATION, National Institute of Technology and Evaluation, Fine Bubble Industries Association
Abstract: A control system and method locates a partially or fully occluded target object in an area of interest. The location of the occluded object may be determined using visual information from a vision sensor and RF-based location information. Determining the location of the target object in this manner may effectively allow the control system to “see through” obstructions that are occluding the object. Model-based and/or deep-learning techniques may then be employed to move a robot into range relative to the target object to perform a predetermined (e.g., grasping) operation. This operation may be performed while the object is still in the occluded state or after a decluttering operation has been performed to remove one or more obstructions that are occluding light-of-sight vision to the object.
Abstract: The present disclosure relates to compositions and methods for modifying a gene sequence, and for systems for delivering such compositions. For example, the disclosure relates to modifying a gene sequence using a CRISPR-Cas9 or other nucleic acid editing system, and methods and delivery systems for achieving such gene modification, such as viral or non-viral delivery systems.
Type:
Grant
Filed:
March 8, 2021
Date of Patent:
December 10, 2024
Assignee:
Massachusetts Institute of Technology
Inventors:
Hao Yin, Wen Xue, Daniel G. Anderson, Joseph R. Dorkin, Tyler E. Jacks
Abstract: Computational and functional analysis identified the neuropeptide receptor Nmur1 as selectively expressed on Type 2 innate lymphoid cells (ILC2s). While both IL-33 and IL-25 promote ILC activation in vivo, IL-33 induces robust ILC proliferation, whereas ILCs activated with IL-25 do not proliferate as robustly and up-regulate Nmur1 expression. Treatment with neuromedin U (NMU), the neuropeptide ligand of Nmur1, had little effect on its own. Co-administration of IL-25 with NMU, however, dramatically amplified allergic lung inflammation and induced the proliferation and expansion of specific ILC2 subsets, characterized by a molecular signature unique to pro-inflammatory ILC2s. The results demonstrate that Nmur1 signaling strongly modulates IL-25-mediated ILC2 responses, resulting in highly proliferative pro-inflammatory ILCs, and highlights the importance of neuro-immune crosstalk in allergic inflammatory responses at mucosal surfaces.
Type:
Grant
Filed:
March 23, 2018
Date of Patent:
December 10, 2024
Assignees:
The Broad Institute, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
Inventors:
Antonia Wallrapp, Samantha J. Riesenfeld, Patrick R. Burkett, Monika S. Kowalczyk, Aviv Regev, Vijay K. Kuchroo
Abstract: An SOx sensor includes a lithium garnet electrolyte, a sensing electrode, a reference electrode, and a heating element. The sensing electrode includes Li2SO4 and at least one metal oxide or second metal sulfate. One surface of the sensing electrode is disposed on at least a portion of a surface of the lithium garnet electrolyte. A current collector is disposed on at least a portion another surface of the sensing electrode to electrically couple the sensing electrode to the reference electrode via a potentiometer. The reference electrode is disposed on the lithium garnet electrolyte. The heating element is capable of heating the sensing electrode and the lithium garnet electrolyte to a temperature sufficient to achieve a sensor response time of less than about 30 minutes.
Type:
Grant
Filed:
December 27, 2021
Date of Patent:
December 10, 2024
Assignee:
Massachusetts Institute of Technology
Inventors:
Jennifer Lilia Rupp, Zachary Hood, Moran Balaish
Abstract: Embodiments of the present disclosure relate to sequential decoding of moderate length low-density parity-check (LDPC) codes via reinforcement learning (RL). The sequential decoding scheme is modeled as a Markov decision process (MDP), and an optimized cluster scheduling policy is subsequently obtained via RL. A software agent is trained to schedule all check nodes (CNs) in a cluster, and all clusters in every iteration. A new RL state space model is provided that enables the RL-based decoder to be suitable for longer LDPC codes.
Abstract: Described herein is an apparatus comprising a base, one or more stands disposed on the base, wherein the stands comprise one or more movement mechanisms configured to move the stands; and one or more translating units disposed on the one or more stands, wherein the one or more translating units comprise a fiber holder. In some embodiments, the one or more translating units are configured to receive and shape a fiber to control spatial degrees of freedom and temporal degrees of freedom of light propagating through the fiber. In some embodiments, each of the one or more translating units can be moved along an x-axis, a y-axis, or a z-axis to manipulate the fiber.
Type:
Application
Filed:
May 30, 2024
Publication date:
December 5, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Sixian You, Tong Qiu, Honghao Cao, Kunzan Liu
Abstract: Cross-ray ultrasound tomography systems and methods that employ an ultrasonic emitter and an ultrasonic detector array where the ultrasonic emitter is outside a plane at elements of the ultrasonic detector array, and ultrasonic wave(s) are emitted by the ultrasonic emitter at an angle to the plane at the elements of the ultrasonic detector array.
Abstract: A method of employing a mixture of two different types of silica as a binary dry coating material to benefit properties of fine milled pharmaceuticals, such as ibuprofen, milled to the mean particle size of ˜10 ?m or smaller. Synergistic effects of reduction in agglomerate size, and improved surface wettability was found by employing a mixture of two different types of silica as the dry coating material in specific ratios. The silica used up to weight percent to 2.31 wt % of a minority component, typically an API or excipient. The silica amount in the entire blend was less than 0.1 wt %. The surface coverage of API was optimized to 50%. Properties were increased when surface coverage by binary coating agents was controlled so that no excess coating agent was available to form agglomerates on the surface.
Type:
Application
Filed:
July 30, 2024
Publication date:
December 5, 2024
Applicant:
New Jersey Institute of Technology
Inventors:
Rajesh N. Dave, Sangah Selene Kim, Zhixing Lin
Abstract: The invention is directed to an article with a liquid-impregnated surface, the surface having a matrix of features thereupon, spaced sufficiently close to stably contain a liquid therebetween or therewithin, and preferable also a thin film thereupon. The surface provides the article with advantageous non-wetting properties. Compared to previous non-wetting surfaces, which include a gas (e.g., air) entrained within surface textures, these liquid-impregnated surfaces are resistant to impalement and frost formation, and are therefore more robust.
Type:
Application
Filed:
February 14, 2024
Publication date:
December 5, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Rajeev Dhiman, J. David Smith, Kripa K. Varanasi, Ernesto Reza-Garduño Cabello
Abstract: Described herein are pancreatic ductal adenocarcinoma (PDAC) signatures and methods of detecting the same in a sample from a subject. Also described herein, are methods of methods of diagnosing, prognosing, and/or treating PDAC in a subject that can include detecting one or more of the PDAC signatures.
Type:
Application
Filed:
August 23, 2024
Publication date:
December 5, 2024
Applicants:
The Broad Institute, Inc., Massachusetts Institute of Technology, THE GENERAL HOSPITAL CORPORATION
Inventors:
William HWANG, Jimmy GUO, Tyler JACKS, Aviv REGEV, Karthik JAGADEESH, Hannah HOFFMAN
Abstract: A sensor including a resonator comprising a nonlinear material comprising a nonlinear susceptibility configured to convert a pump electromagnetic wave (EM) wave to a signal EM wave and an idler EM wave, wherein at least one of the pump EM wave, the signal EM wave and/or the idler EM wave is fed back through the nonlinear material to form one or more resonant EM waves. An actuator coupled to the resonator or a pump path to the resonator, controls at least one of a pump power of the pump EM wave, a detuning of the frequency modes of the resonator relative to one or more frequencies of the resonant EM waves, or a phase matching of the nonlinear material. An output of the resonator outputs one or more output EM waves comprising information about a sample coupled to the resonator.
Type:
Application
Filed:
May 15, 2023
Publication date:
December 5, 2024
Applicant:
California Institute of Technology
Inventors:
Robert M. Gray, Selina Zhou, Mingchen Liu, Arkadev Roy, Alireza Marandi
Abstract: Described herein is a semiconductor structure, comprising: a drain region; a drift region comprised of a wide band gap material disposed over the drain region; and a channel structure disposed over the drift region. In some embodiments, the channel structure comprises: an optically active material disposed over the drift region, wherein the optically active material generates charge carriers in response to an optical signal; and a source region disposed over the optically active material, wherein in an off state charge carriers in the optically active material are depleted to turn off the semiconductor structure, and in an on state charge carriers in the optically active material conduct a current in the semiconductor structure when an electric field is applied across the source region and drain region, causing the current to substantially flow directly between the source region and the drain region.
Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.