Abstract: Conjugates for the efficient delivery of sequence-specific antisense to cells of a selected type for the inhibition of a target protein have the general formula: peptide-HBL-antisense in which the peptide is a homing peptide which directs the conjugate to cells of a particular type, antisense is an antisense oligonucleotide having a sequence selected to provide sequence-specific inhibition of the target protein, and HBL is a heterobifunctional linker having reactivity towards amino and sulfhydryl groups.
Type:
Grant
Filed:
November 24, 2014
Date of Patent:
July 19, 2016
Assignee:
Sloan-Kettering Institute for Cancer Research
Abstract: Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and proteins, and may further comprise additional layers of polyions. In some embodiments, decomposable thin films and methods of using such films allow proteins to be released over an extended period of time and/or retention of as much as 100% of function of released protein.
Abstract: Disclosed is a multi-stage plasma reactor system with hollow cathodes for cracking carbonaceous material with each stage comprising: hollow cathodes and hollow anodes cooled by recycling cooling medium or refrigerant; working gas inlet(s); inlet(s) of carbonaceous material and carrier gas as feedstock; reaction tubes in connection with the anode or cathode, in addition, the reactor system also comprises: at least one inlet(s) of quench medium located lower portion of last one of the reaction tubes; and at least one outlet(s) of quenched products and gases located on bottom or lower portion of last one of the reaction tubes, wherein chambers are formed between the first hollow cathode or the hollow cathode used as the reaction tube of any stage and the anode so as to generate plasma gas and/or electric arc therein, generated plasma gas jet fully contacts and efficiently mixes with the carbonaceous material and carrier gas as feedstock and/or volatiles caused by pyrolysis within or nearby highest temperature re
Type:
Grant
Filed:
August 3, 2012
Date of Patent:
July 19, 2016
Assignees:
National Institute of Clean-and-Low-Carbon Energy, Shenhua Group Corporation Limited
Inventors:
Xuan Li, Binhang Yan, Changning Wu, Yi Cheng, Yi Guo
Abstract: A method and system for cooperative diversity visual cognition in a wireless sensor network is disclosed. The method and system are capable of solving distributed visual cognition tasks (for example, online simultaneous reconstruction of 3D models of a large area) by using multiple video streams and exploiting cooperative diversity video sensing information while ensuring an optimal tradeoff between energy consumption and video quality of images received from said multiple video streams.
Type:
Grant
Filed:
May 24, 2012
Date of Patent:
July 19, 2016
Assignees:
Siemens Corporation, Siemens Aktiengesellschaft Osterreich, The Trustees of the Stevens Institute of Technology
Inventors:
Maneesh Kumar Singh, Cristina Comaniciu, Dorin Comaniciu, Stefan Kluckner
Abstract: A positioning control method, suitable for an electronic device moving along with a vehicle, is provided in this disclosure. The electronic device includes an image-capturing module and a satellite-based positioning module. The positioning control method includes steps of: capturing a first image; extracting an icon object from the first image; capturing a second image; identifying the corresponding icon object in the second image; calculating a separation distance between the electronic device and the icon object according to a variance of the icon object between the first and the second images and a displacement distance of the vehicle; searching a point-of-interest (POI) corresponding to the icon object from a POI database; and, calculating/calibrating positioning data of the electronic device according to the separation distance and known coordinates of the POI.
Abstract: An electric conduction heat dissipation substrate includes a ceramic substrate, and a seed layer, and a buffering material layer and a copper circuit layer formed thereon in order. The buffering material layer has a coefficient of thermal expansion between those of the ceramic substrate and the copper circuit layer. Moreover, the buffering material layer is composed of alloy material and ceramic material or composed of metal material and ceramic material.
Type:
Grant
Filed:
May 27, 2014
Date of Patent:
July 19, 2016
Assignee:
Industrial Technology Research Institute
Abstract: An automatic sheet grinding apparatus includes a stationary stage positioned at a lower portion of the automatic sheet grinding apparatus, a sheet holder positioned on the stationary stage to grip the sheet, and a grinding head part having a chuck assembly fixed to the grinding head part through a spindle, spaced apart from the sheet holder, positioned on the stationary stage, and having a grinding disc attached to the chuck assembly to grind the sheet provided in the sheet holder. The grinding head part includes a thickness measuring unit to measure a thickness of the sheet, and a hardness measuring unit to measure hardness of the sheet. The automatic sheet grinding apparatus further includes rails positioned on the stationary stage and extending in parallel to each other. In this case, the sheet holder is securely and movably provided on the rails positioned on the stationary stage to grip the sheet.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
July 19, 2016
Assignee:
KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCES
Inventors:
Rae-Hee Han, Ki-Sung Sung, Jeong-Chan Kim
Abstract: A method for evaluation of cable aging degradation based on slice sampling is revealed. An insulation layer of a cable is aged or degraded from the outside in under influence of high temperature, liquid immersion, radiation exposure, or other factors. The present invention gets slices as samples of the cable by cutting from the outside in. Then related tests including dielectric withstand test, insulation resistance measurement, elongation test, etc. are carried out. Besides the state of cable aging degradation being of the slice being found out, different positions in the insulation layer such as an outer layer, a middle layer and an inner layer can also be evaluated.
Type:
Grant
Filed:
June 6, 2014
Date of Patent:
July 19, 2016
Assignee:
Atomic Energy Council—Institute of Nuclear Energy Research
Abstract: A system includes: a splitter to branch an optical signal output by a wavelength-tunable light source into first to third optical signals; a first photodiode to perform an optical electrical conversion of the first optical signal transmitting a first etalon; a second photodiode to perform an optical electrical conversion of the second optical signal transmitting a second etalon, an FSR of the second etalon being identical to that of the first etalon, peak wavelengths of intensity of a transmitted light of the second etalon being different from those of the first etalon; a third photodiode to perform an optical electrical conversion of the third optical signal; and a controller to control the wavelength-tunable light source with use of a coefficient calculated by following formulas (1) or (2), Coefficient=(PD1?A·PD3)/(PD2?B·PD3) (1) and Coefficient=(PD2?B·PD3)/(PD1?A·PD3) (2).
Type:
Grant
Filed:
September 17, 2014
Date of Patent:
July 19, 2016
Assignees:
Sumitomo Electric Industries, Ltd., National Institute of Advanced Industrial Science and Technology
Inventors:
Katsumi Uesaka, Eiichi Banno, Hajime Shoji, Hiroyuki Matsuura, Haruhiko Kuwatsuka, Ken Tanizawa, Shu Namiki
Abstract: Provided are a meta-photoresist capable of transferring mask patterns on which fine patterns having a diffraction limit or less are formed, on a substrate, and a lithography method using the same, wherein the meta-photoresist contains a photosensitive resin layer and a metal particle layer which is a layer of metal particles arranged so as to be spaced apart from each other.
Type:
Grant
Filed:
June 4, 2014
Date of Patent:
July 19, 2016
Assignee:
Korea Advanced Institute of Science and Technology
Inventors:
Ki-Hun Jeong, Youngseop Lee, Jae-Beom Kim
Abstract: Provided is a methionyl tRNA synthase (MRS) for the biosynthesis of a photomethionine-labeled protein and a method for preparing a photoactivatable protein G variant using same and, more particularly, to an MRS variant in which alanine at the position of 12th is substituted with glycine, leucine at the position of 13th by serine, tyrosine at the position of 260th by phenylalanine, isoleucine at the position of 297th by valine, and histidine at the position of 301st by leucine from the N-terminal of the amino acid sequence of a wild-type Escherichia coli methionyl tRNA synthase. The MRS variant effectively confirms the biosynthesis of a photomethionine (pM)-labeled target protein and thus can be utilized for the biosynthesis of a pM-labeled target protein.
Type:
Application
Filed:
May 29, 2014
Publication date:
July 14, 2016
Applicant:
Korea Research Institute of Bioscience and Biotechnology
Inventors:
Myung Kyu Lee, Bong Hyun Chung, Jeong Hee Moon, Ga Bi Lee
Abstract: Disclosed is a particle manipulation method including steps of moving particles, which exist in a water-based liquid, into a gelled medium that is insoluble or hardly soluble in the water-based liquid in the water-based liquid, and moving the particles, which exist in the gelled medium, to the outside of the gelled medium. Preferably, the gelled medium is a gel that contains chemically crosslinking polymer. Preferably, the gelled medium has a consistency of 340 to 475. In one embodiment, the movement of the particles existing in the water-based liquid to the gelled medium and the movement of the particles existing inside the gelled medium to the water-based liquid are carried out inside a device, the device being loaded with a plurality of water-based liquids and a gelled medium interposed among the water-based liquids.
Type:
Application
Filed:
July 3, 2013
Publication date:
July 14, 2016
Applicants:
SHIMADZU CORPORATION, KAZUSA DNA RESEARCH INSTITUTE
Abstract: The present disclosure provides a method for distributing gas for oxy-fuel combustion on a circulating fluidized bed. In the method, the gas is provided by three stages into a furnace of the circulating fluidized bed. The method includes: blowing in a first-stage gas containing oxygen and recycled flue gas from the bottom of the furnace; blowing in a second-stage gas containing recycled flue gas from a transition zone between a dense-phase zone and a dilute-phase zone of the furnace; and blowing in a third-stage gas containing oxygen from a side wall of the furnace.
Type:
Application
Filed:
November 6, 2014
Publication date:
July 14, 2016
Applicant:
Institute of Engineering Thermophysics, Chinese Academy of Sciences
Abstract: A contactless, three-dimensional fingerprint scanner apparatus, method, and system are described. The contactless fingerprint scanner can provide either, or both, topographical contrast of three-dimensional fingerprint features and optical contrast of a three-dimensional fingerprint surface. Data captured from scanning of a target with known geometric features mimicking fingerprint features can be examined as images or surface plots and analyzed for fidelity against the known target feature specifications to evaluate or validate device capture performance as well as interoperability. The target can be used by scanner vendors and designers to validate their devices, as well as to perform type certification.
Type:
Application
Filed:
January 14, 2016
Publication date:
July 14, 2016
Applicant:
Govt. of the U.S.A. as represented by the Sec. of Commerce, The National Institute of Standards and
Inventors:
Shahram Orandi, Fred Byers, Stephen Harvey, Michael D. Garris, Stephen S. Wood, John M. Libert, Jin Chu Wu
Abstract: Provided is an apparatus for allocating resources of a distributed data processing system by considering a virtualization platform, the apparatus including: a resource usage monitor configured to scan one or more available virtual machines that execute one or more selected tasks in one or more physical machines, and to calculate a distance between the one or more scanned available virtual machines based on physical machine information received from the one or more physical machines; and a task allocator configured to allocate the one or more selected tasks to one or more virtual machines selected from among the one or more scanned available virtual machines based on the calculated distance between the one or more scanned available virtual machines.
Type:
Application
Filed:
January 12, 2016
Publication date:
July 14, 2016
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Hyun Hwa CHOI, Byoung Seob KIM, Seung Jo BAE
Abstract: Self-sustained, safe, stable and scalable microbial consortia (S5MicroCon) are described. The microbial consortia are regulated by photoautotroph-heterotroph interactions and RNA aptamer-based gene circuits. A rapid, high-throughput method for engineering RNA aptamer-based gene circuits (e.g. riboswitches) is also described.
Type:
Application
Filed:
January 8, 2016
Publication date:
July 14, 2016
Applicant:
Battelle Memorial Institute
Inventors:
Alex S. Beliaev, Ryan S. McClure, Hans C. Bernstein, Stephen R. Lindemann, G. Chris Jansson
Abstract: A synthesis gas and nanocarbon production method has a lower hydrocarbon decomposition step for decomposing lower hydrocarbon to produce hydrogen and nanocarbon, a carbon dioxide reduction step for reacting a part of the nanocarbon produced with carbon dioxide to produce carbon monoxide, and a mixing step for mixing the hydrogen and carbon monoxide produced in a predetermined ratio, thereby nanocarbon and a synthesis gas having a desired gas ratio can be simultaneously produced easily.
Type:
Application
Filed:
March 23, 2016
Publication date:
July 14, 2016
Applicants:
THE JAPAN STEEL WORKS, LTD., National University Corporation Kitami Institute of Technology
Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of tissue injury caused by irradiation which comprises silkworm hemolymph as an active ingredient. Particularly, when the silkworm hemolymph of the present invention was administered to an animal model with liver damage induced by irradiation, plasma AST and liver MDA were significantly decreased, indicating that the silkworm hemolymph of the invention can be effectively used as a composition for the prevention and treatment of disease caused by the exposure on radiation including tissue injury caused by irradiation, etc.
Type:
Application
Filed:
March 21, 2016
Publication date:
July 14, 2016
Applicant:
KOREA ATOMIC ENERGY RESEARCH INSTITUTE
Inventors:
Sang Hyun Park, Beom Su Jang, YouRee Nam
Abstract: To provide a lithium ion secondary battery capable of suppressing thermal run-away when internal short circuiting occurs. The lithium ion secondary battery includes: a positive electrode including a current collector, a positive electrode active material layer that is formed on the current collector and that contains a lithium-containing complex oxide having a layered rock salt structure and being represented by general formula: LiaNibCocMndDeOf (0.2?a?1; b+c+d+e=1; 0?e<1; D is at least one element selected from Li, Fe, Cr, Cu, Zn, Ca, Mg, S, Si, Na, K, and Al; 1.7?f?2.1), and a thermal run-away suppressing layer formed on the positive electrode active material layer and containing a lithium transition metal silicate; and a negative electrode including a negative electrode active material. A ratio of the mass of the lithium-containing complex oxide with respect to the mass of the lithium transition metal silicate in the positive electrode is not lower than 1.5.
Type:
Application
Filed:
July 17, 2014
Publication date:
July 14, 2016
Applicants:
KABUSHIKI KAISHA TOYOTA JIDOSHOKKI, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
Inventors:
Yuta IKEUCHI, Toshikatsu KOJIMA, Tetsuo SAKAI, Tatsuya EGUCHI, Hitoshi AIKIYO, Akira KOJIMA
Abstract: An objective of the present invention is to provide a surfactant composition which hardly causes the formation of an insoluble salt and which contains a safe and extremely stable micelle or vesicle. Also, an objective of the present invention is to provide a hair cosmetic material which contains the surfactant composition. The surfactant composition according to the present invention is characterized in comprising a micelle or a vesicle which contain surfactin and a specific cationic surfactant.
Type:
Application
Filed:
August 11, 2014
Publication date:
July 14, 2016
Applicants:
Kaneka Corporation, National Institute of Advanced Industrial Science and Technology