Abstract: Method and apparatus for handwriting recognition system for ideographic characters and other characters based on subcharacter hidden Markov models. The ideographic characters are modeled using a sequence of subcharacter models and by using two-dimensional geometric layout models of the subcharacters. The subcharacter hidden Markov models are created according to one embodiment by following a set of design rules. The combination of the sequence and geometric layout of the subcharacter models is used to recognize the handwriting character.

Abstract: The present invention discloses a gyroscope comprising an isolated resonator including a post proof mass and counterbalancing plate. One or more double beam flexures each interconnect the counterbalancing plate and the proof mass with a first and a second beam attached to the post proof mass and a third and a fourth beam attached to the counterbalancing plate. A baseplate is affixed to the resonator by the double beam flexures. The counterbalancing plate and the proof mass transfer substantially no net momentum to the baseplate when the resonator is excited.

Abstract: A gene activation/inactivation and site-specific integration system has been developed for mammalian cells. The invention system is based on the recombination of transfected sequences by FLP, a recombinase derived from Saccharomyces. In several cell lines, FLP has been shown to rapidly and precisely recombine copies of its specific target sequence. For example, a chromosomally integrated, silent ?-galactosidase reporter gene was activated for expression by FLP-mediated removal of intervening sequences to generate clones of marked cells. Alternatively, the reverse reaction can be used to target transfected DNA to specific chromosomal sites. These results demonstrate that FLP can be used, for example, to mosaically activate or inactivate transgenes for a variety of therapeutic purposes, as well as for analysis of vertebrate development.

Abstract: The present invention describes methods for producing binding sites on polypeptides, and particularly for producing binding sites within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles. The invention also describes oligonucleotides useful for preparing the binding sites, and human monoclonal antibodies produced by the present methods.

Abstract: A rugged, miniature, spectroscopic gas analyzer apparatus for rapid, non-invasive, multi-component breath monitoring and analysis and subsequent determination of Q or other medical diagnostic applications. The system is comprised of one or more IR emitters focussed by optical elements through a low volume sample cell receiving a sample input of a patient's breath for analysis. The patient either at rest or during exercise, inhales C2H2—SF6 mixtures (balance of oxygen and nitrogen) which is subsequently monitored upon exhalation for CO2, H2O, C2H2, and SF6 which can be employed to determine Q directly and accurately. Measurements are performed in real-time or via post-processing of stored original data. Due to its small size, ruggedness, and low power consumption, the monitor can conveniently be employed in the field or data can also be retrieved remotely using telemetry.

Abstract: A stabilized optical pulse generator using RHML-FRL is provided. The stabilized optical pulse generator comprises an optical fiber ring composed of optical fibers, an optical amplifier and a modulator for optical modulation, an electric signal generator generating high frequency signals and an optical pulse stabilizer. The device generates an optical pulse train of repeating frequency of fm, when applying electric signals of frequency of fm to the modulator. Wherein, for a resonance frequency of the optical fibers of fc, the modulating frequency applying to the modulator is detuned from the electric signal of the frequency of fm by frequency of the resonance frequency fc divided by integer of p. Optical pulse trains of repeating frequency of p times of fm+fc/p or fm?fc/p are generated.

Abstract: Provided is a differential pair interconnection apparatus for providing a differential signal on a printed circuit board having signal paths for high-speed differential signals to an external circuit and providing a signal inputted from the external circuit to the printed circuit board without any signal distortion. According to the differential pair interconnection apparatus of the present invention, there can be provided two separate physical channels without impedance mismatching.

Abstract: The present invention provides an image composing apparatus that can composite images at high speed and in which the apparatus configuration can be easily expanded as the number of images to be composed increases. Sub-images generated by node computers are synchronized each other by a synchronizing section. Then, each pair of synchronized sub-image data is composed into a single sub-image in a first-layer image composing section, comprising a plurality of image composing circuits each for composing two sub-images, and the resulting sub-images are composed iteratively through a second-layer image composing section, a third-layer image composing section, and so on, that have the same configuration as the first-layer image composing section.

Abstract: A dictionary coupler using a non-radiative dielectric waveguide is disclosed. Particularly, a millimeter wave band non-radiative dielectric waveguide directional coupler using a multiple-hole structure in which two parallel NRD waveguides located between upper and lower conductive plates and a conductive plate having a multiple-hole structure is inserted between two NRD waveguides to couple electric and magnetic waves of an electric field component or a magnetic field component is provided.

Abstract: The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such compounds in the treatment of disorders involving CD38 modulated cell migration. The invention is based on the discovery that CD38 ADP-ribosyl cyclase activity is required for chemotaxis. Furthermore, the invention relates to methods for identifying compounds that modulate the enzyme activity of the S. mansoni CD38 homologue and using those compounds in the treatment of pathologic disorders caused by helminth infection.

Abstract: Umbilics of two surfaces are compared and it is determined from this comparison whether the suspect surface is a copy of the original surface based on the comparison. Comparing umbilics includes determining whether locations of the umbilics of the suspect surface match within a specified margin umbilics of the original surface, and determining whether pattern types of umbilics of the suspect surface match pattern types of corresponding umbilics of the original surface. A “weak” test may be performed, in which corresponding points on the two surfaces are compared, wherein the comparison of umbilics is performed if corresponding points of the two surfaces are located within a specified margin of each other. The points may be gridpoints on wireframes, which in turn may be based on lines of curvature of the surfaces. Comparing umbilics is performed if it is determined that each surface has at least one umbilic.

Abstract: Integrated sensors are described using lasers on substrates. In one embodiment, a first sensor forms a laser beam and uses a quartz substrate to sense particle motion by interference of the particles with a diffraction beam caused by a laser beam. A second sensor uses gradings to produce an interference. In another embodiment, an integrated sensor includes a laser element, producing a diverging beam, and a single substrate which includes a first diffractive optical element placed to receive the diverging beam and produce a fringe based thereon, a scattering element which scatters said fringe beam based on particles being detected, and a second diffractive element receiving scattered light.

Abstract: The invention is a gene coding for a quinone oxidoreductase from Kluyveromyces marxianus and a protein having an amino acid sequence expressed therefrom, which can be advantageously used in a reduction reaction of a quinone compound and synthesis of intermediates for a biologically active compound.

Abstract: A new eco-friendly process is described in the present invention for the preparation of bromobenzene through substitution of one of the C—H proton of benzene ring with a highly reactive hypobromous acid generated in situ, said process comprises the steps of activating a water soluble, easy to handle, brominating reagent with a mineral acid at elevated temperature and atmospheric pressure to generate active bromine species which in turn reacts with benzene.

Abstract: The embodiments of the invention are directed to a new apparatus and method of measuring the water content using time domain reflectometry (TDR), or electrical conductivity in deep soil levels to. The method uses flat, flexible, waveguides attached to a flexible sleeve filled with a filling material which press the flexible waveguides against an irregularly shaped interior borehole wall.

Abstract: The present invention provides an isolated nucleic acid molecule encoding a PFM/SET polypeptide. Also provided is an isolated nucleic acid molecule encoding a functional fragment of a PFM/SET polypeptide that contains a PR, SET, PRAZ or PKZL domain of a PFM/SET polypeptide of the invention. Further provided by the invention are PFM/SET polypeptides, and functional fragments thereof that contain a PR, SET, PRAZ or PKZL domain of a PFM/SET polypeptide. The invention also provides PFM/SET antibodies, PFM/SET modulatory compounds, and related methods. The molecules of the invention can be used in methods of screening for a compound that modulates PFM/SET polypeptide histone methyltransferase activity and to modulate cell proliferation to prevent or treat proliferative disorders, including cancer. Additionally, the molecules and methods of the invention can be used to diagnose and prognose proliferative disorders.

Abstract: High throughput DNA sequencing vectors for generating nested deletions using enzymatic techniques and/or transposition-based techniques are disclosed. Methods of constructing contigs of long DNA sequences and methods of generating nested deletions are also disclosed. A truncated lacZ derivative useful in measuring the copy number of the lacZ derivative in a host cell is also disclosed.

Abstract: The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.

Abstract: The invention relates in part to methods of making single-domain antibodies and methods of using single-domain antibodies to diagnose and treat disease. The invention also relates to methods and products for modulating target protein activity, including methods to inhibit huntingtin protein aggregation in Huntington's disease. The invention also includes methods and compounds for identifying pharmaceutical agents for preventing and treating diseases and for monitoring the efficacy of treatments for target protein-associated diseases.