Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A method for identifying and evaluating toxigenic capability of an aflatoxigenic strain. A ratio of the aflatoxin yield to Nor-1 gene transcriptional quantity is determined to have high relative stability. An Aspergillus flavus strain toxigenic capability identification model is established, and thus a regression equation between the Aspergillus flavus toxigenic capability and the ratio AFT/Nor-1 of the aflatoxin yield to the Nor-1 gene transcriptional quantity is obtained.

Abstract: An object of the present invention is to provide a method other than the scavenger function against reactive oxygen species for molecular hydrogen to improve life functions, in the fields of medical science, medical care, health industry, agriculture, animal husbandry, and fisheries, and an effect of improving mitochondrial function utilizing the same, and an anticoagulation agent, a blood coagulation curing device, a blood coagulation curing method, and a vascular endothelial cell function improving method. Provided is an anticoagulation agent composed of hydrogen gas or an anticoagulation agent composed of water containing molecular hydrogen. Preferably the anticoagulation agent is such that molecular hydrogen improves mitochondrial function by increasing mitochondrial hydrogenase activity, thereby improving blood clotting.

Abstract: A method of modifying an upstream open reading frame (uORF) by genome editing technique to regulate gene expression.

Abstract: Preparation of phosphorus fine chemicals from phosphate sources is described.

Abstract: Various examples of the present disclosure provide a manufacturing system and method for providing a variable pressure environment, which are applied to additive manufacturing and subtractive manufacturing, such as metal-based additive and subtractive manufacturing, hybrid additive and subtractive manufacturing, or ultrasonic hybrid additive manufacturing, etc. According to the examples of the present disclosure, a variable pressure environment is provided within the seal pressure vessel so as to implement the manufacturing process in the hyperbaric pressure environment. Thus, for a manufacturing process using metals as raw materials, various issues caused by metallurgical defects of the metals can be effectively suppressed. The storage vessel of the inert gas is safe and stable to the hyperbaric pressure environment, so that a manufacturing process applying a continuous and uniform hyperbaric pressure is achieved.

Abstract: A thin film heater includes a heat conductive layer, a heat insulation layer and a heat generation layer. The heat generation layer is disposed between the heat conductive layer and the heat insulation layer. The thermal conductivity of the heat conductive layer is greater than or equal to three times the thermal conductivity of the heat insulation layer.

Abstract: A waist imitating device of robotic rat based on multiple-connecting-rod transmission comprises a pitch parallel connecting rod group (8) and a yaw parallel connecting rod group (2). The pitch parallel connecting rod group (8) and the yaw parallel connecting rod group (2) are respectively connected with a front joint and a back joint of a waist of a robotic rat. Under the drive of a first motor (4), crank connecting rods drive the yaw parallel connecting rod group (2) such that left-right yaw motion of the waist of the robotic rat relative to wheels and forelimbs can be achieved. Under the drive of a second motor (14), crank connecting rods drive the pitch parallel connecting rod group (8) such that upper-down pitch motion of the waist of the robotic rat relative to the wheels and the forelimbs can be achieved.

Abstract: An optical fiber scanning probe includes a rotor and at least one optical fiber. The rotor includes a torque rope rotatable about its central axis. The optical fiber is disposed on the rotor and eccentric relative to the torque rope. A central axis of the optical fiber is substantially parallel to the central axis of the torque rope. When the torque rope rotates about its central axis, the rotor brings a free end of the optical fiber to scan along an arc path.

Abstract: A dynamic correction system of a manufacturing process using wire is provided. The dynamic correction system includes a driving device, a path sensor, and a controller. The driving device is configured to: drive a carrier with a motion parameter and encapsulate the carrier with a wire. The path sensor is configured to obtain an actual path information of the wire encapsulating the carrier. The controller is configured to: obtain an actual path of the wire encapsulating the carrier according to the actual path information; obtain an actual path difference between a target path and the actual path; determine whether the actual path difference is greater than a predetermined error; and, when the actual path difference is greater than the predetermined error, control the driving device to change the motion parameter to cause the actual path of the wire encapsulating the carrier to approach the target path.

Abstract: The present invention is a laminate: with which differences in the thermal expansion coefficient at interfaces between different materials in the interior of a semiconductor element or the like can be kept small; which has high heat resistance; and which has high thermal conductivity. This laminate is provided with at least two layers of thermal expansion-controlling members, the thermal expansion-controlling members including a thermally conductive first inorganic filler joined to one end of a first coupling agent, and a thermally conductive second inorganic filler joined to one end of a second coupling agent; the other end of the first coupling agent and the other end of the second coupling agent are respectively joined to a polymerizable compound, or joined to one another; and the thermal expansion-controlling members have thermal expansion coefficients that are respectively different.

Abstract: An automatic guided vehicle positioning system includes one or more positioning areas and an automatic guided vehicle. The positioning areas each have a positioning pattern. The automatic guided vehicle includes a beam emitter, a beam receiver, and a processor. The beam emitter is configured to emit a light beam to scan the positioning areas. The beam receiver is configured to be spaced apart from the beam emitter by a specific distance, wherein the beam receiver receives the light beam scattered by an area other than the corresponding positioning pattern of the positioning areas and does not receive the light beam retroreflected by the corresponding positioning pattern. The processor is configured to recognize the corresponding positioning pattern based on the light beam received by the beam receiver and the retroreflected light beam not received by the beam receiver and to position the automatic guided vehicle.

Abstract: The present invention relates to a connecting apparatus for a steam generator disposed between a steam generator and a flow mixing header to fasten the steam generator to the flow mixing header in a sealed manner, and an integral reactor including the same. The connecting apparatus for a steam generator disposed between a steam generator and a flow mixing header and fastening the steam generator to the flow mixing header in a sealing manner includes: a baseplate mounted on the flow mixing header and having a through hole formed at the center thereof; and a steam generator connecting portion protruding along the circumference of the through hole in the base plate and allowing an outlet of the steam generator to be inserted and fastened thereto.

Abstract: A method and a device for encoding/decoding an image according to the present invention may determine a reference region for intra prediction of a current block, derive an intra prediction mode of the current block on the basis of a predetermined MPM candidate group, and perform intra prediction on the current block on the basis of the reference region and the intra prediction mode.

Abstract: Provided is a novel material analysis technique using a chemical sensor. By reversing the conventional approach, a material to be measured is provided as a receptor of the chemical sensor, and a response signal of the chemical sensor obtained by supplying a known gas or the like to the chemical sensor is obtained. From the response signal, it is possible to identify and distinguish the receptor material, and to obtain its composition and the like. By analyzing the response signal by means of a statistical or machine learning technique such as principal component analysis, linear discriminant analysis, or a support vector machine, the above-mentioned identification and the like can be performed with high accuracy.

Abstract: A biodegradable iron-based alloy composition, a medical implant applying the iron-based alloy composition, and a manufacturing method of the medical implant are provided. The biodegradable iron-based alloy composition includes at least 98 wt % of iron and 2 wt % or less of an additional material. The additional material includes 0.1 wt %-0.8 wt % of Mn, 0.01 wt %-0.15 wt % of Mo, 0.1 wt %-0.3 wt % of Cr, 0.02 wt %-0.15 wt % of C, and 0.01 wt %-0.15 wt % of Si.

Abstract: The present disclosure relates to a celastrol or a pharmaceutically acceptable salt thereof, and a use thereof in the manufacture of a medicament for preventing and/or treating a cholestatic liver disease or a liver fibrosis.

Abstract: A PCR vessel having: a substrate, a flow channel formed in the substrate, a pair of filters provided at both ends of the flow channel, a pair of air communication ports communicating with the flow channel through the filters, a thermal cycle region formed between the pair of filters in the flow channel, and a sample injection port through which a sample can be injected into the flow channel from above; wherein the sample injection port in the surface of the substrate has an area of 0.7 to 1.8 mm2.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A method for compensating a design image of a workpiece and a system for processing the design image of the workpiece are disclosed. The method includes the following steps. Obtaining a real image of the workpiece, with the real image having registration holes. Calculating a slope value for each of the registration holes. Determining an amount of interpolation points between each two neighboring registration holes of the registration holes according to the slope value corresponding to each of the registration holes. Obtaining positions of control points in blocks formed by the registration holes. Compensating the design image of the workpiece according to positions of the registration holes, positions of the plurality of interpolation points and the positions of the control points for generating a mapping image. Outputting the mapping image adapted to be mapped onto the workpiece. The system, together with the method, will be introduced.