Abstract: The disclosure relates to compositions containing allyl isothiocyanate and methods of use thereof for stimulating tearing in a subject to treat dry eye.
Type:
Grant
Filed:
August 20, 2018
Date of Patent:
January 17, 2023
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.
Type:
Grant
Filed:
July 26, 2018
Date of Patent:
January 17, 2023
Assignee:
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
Inventors:
Varda Shoshan-Barmatz, Yakov Krelin, Avijit Paul
Abstract: A system including: an active magnetic regenerative refrigerator apparatus that includes a high magnetic field section in which a hydrogen heat transfer fluid can flow from a cold side to a hot side through at least one magnetized bed of at least one magnetic refrigerant, and a low magnetic field or demagnetized section in which the hydrogen heat transfer fluid can flow from a hot side to a cold side through the demagnetized bed; a first conduit fluidly coupled between the cold side of the low magnetic field or demagnetized section and the cold side of the high magnetic field section; and a second conduit fluid coupled to the first conduit, an expander and at least one liquefied hydrogen storage module.
Type:
Grant
Filed:
December 10, 2021
Date of Patent:
January 17, 2023
Assignees:
Battelle Memorial Institute, Emerald Energy NW, LLC
Abstract: In some embodiments, a superconducting parametric amplification neural network (SPANN) includes neurons that operate in the analog domain, and a fanout network coupling the neurons that operates in the digital domain. Each neuron is provided one or more input currents having a resolution of several bits. The neuron weights the currents, sums the weighted currents with an optional bias or threshold current, then applies a nonlinear activation function to the result. The nonlinear function is implemented using a quantum flux parametron (QFP), thereby simultaneously amplifying and digitizing the output current signal. The digitized output of some or all neurons in each layer is provided to the next layer using a fanout network that operates to preserve the digital information held in the current.
Abstract: Provided are catalysts for reduction of nitrogen oxides including an active site including lanthanum vanadate represented by at least one of Formula 1 and Formula 2 and a support carrying the active site. LaVO4 (wherein LaVO4 is polymorphous and has a tetragonal or monoclinic crystal structure)??Formula 1 LaV3O9 (wherein LaV3O9 has a monoclinic crystal structure)??Formula 2.
Type:
Grant
Filed:
December 30, 2020
Date of Patent:
January 17, 2023
Assignee:
Korea Institute of Science and Technology
Inventors:
Jongsik Kim, Heon Phil Ha, Dong-Wook Kwon
Abstract: Disclosed in the embodiments of the present invention are an OAM message transmission method and transmission device, and a storage medium. The OAM message transmission method comprises: obtaining an OAM block generated on the basis of an OAM message; replacing an idle block in a data stream with the OAM block; and sending the data stream carrying the OAM block.
Type:
Grant
Filed:
August 17, 2018
Date of Patent:
January 17, 2023
Assignees:
CHINA MOBILE COMMUNICATION CO., LTD RESEARCH INSTITUTE, CHINA MOBILE COMMUNICATIONS GROUP CO., LTD.
Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
January 17, 2023
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Jungyeob Ham, Taejung Kim, Bong Chul Chung, Seok Lee, Bong Geun Song, Sungdo Ha, Young Tae Park, Pilju Choi, Hoon Ryu
Abstract: A nanofiber membrane includes a polymer nanofiber; and an amphiphilic triblock copolymer bonded to the surface of the polymer nanofiber, the amphiphilic triblock copolymer includes a hydrophobic portion; hydrophilic portions positioned at both ends of the hydrophobic portion; and a low surface energy portion positioned at one end of each of the hydrophilic portions positioned at both ends of the hydrophobic portion, and the hydrophobic portion of the amphiphilic triblock copolymer is bonded to the surface of the polymer nanofiber and the hydrophilic portion and the low surface energy portion are exposed to the outside of the surface of the polymer nanofiber. The membrane simultaneously exhibits hydrophilicity, underwater oleophobicity, and low oil adhesion force, thus has surface segregation properties, and as a result, has an excellent oil permeate flux, exhibits antifouling properties, and can excellently separate oil in water.
Type:
Grant
Filed:
May 12, 2021
Date of Patent:
January 17, 2023
Assignee:
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Hee Chul Choi, So Young Kim, Yejin Liang
Abstract: A method of controlling the charge current during charging of a lithium-ion battery. A battery charging controller is based on a Kalman filter, which uses estimated battery states to generate a feedback metric to continually adjust a battery cell model. The battery cell model then delivers data to an optimization process that generates the charge current.
Abstract: Disclosed herein are methods for inducing insulin secretion in a glucose-dependent manner and compounds for use in these methods. The compounds may have the structure of formula I(a): wherein the substituents are as described in the description; or a pharmaceutically acceptable form thereof.
Type:
Grant
Filed:
March 19, 2018
Date of Patent:
January 17, 2023
Assignees:
The Broad Institute, Inc., The General Hospital Corporation, Instituto Carlos Slim de la Salud, A.C.
Inventors:
Sean M. Burns, Bridget K. Wagner, Amedeo Vetere
Abstract: The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.
Abstract: The present disclosure relates to a feedforward structure for controlling water level, in particular to a feedforward structure for controlling a steam drum water level in a steam turbine FCB test and a control method therefor. The feedforward structure includes a steam drum provided with a steam drum water level measurement sensor therein, a feed water pipe provided with a feed water flow measurement sensor therein, and a steam inlet pipe provided with a steam flow measurement sensor therein. A steam drum water level measurement value I in the steam drum water level measurement sensor is compared with a set value of the steam drum water level.
Type:
Grant
Filed:
August 19, 2021
Date of Patent:
January 17, 2023
Assignee:
China Energy Engineering Eastern Electric Power Testing Research Institute Co., Ltd.
Abstract: A gene ansB knockout mutant of Citrobacter werkmanii and an application thereof are provided. The gene ansB knockout mutant of the C. werkmanii is C. werkmanii with a gene ansB knocked out and a nucleotide sequence of the gene ansB is as shown in SEQ ID NO: 1. In the present invention, the acquired engineering bacteria with the gene ansB of the C. werkmanii knocked out are cultured in LB, TSB, NB and other media at 25° C. and 30° C., so that a biofilm formation capacity of the C. werkmanii on a polypropylene material is improved. Thus, the application scenarios and scopes of the C. werkmanii in heavy metal ion adsorption and construction of cellular protein synthesis micro-factories are broadened.
Type:
Grant
Filed:
March 22, 2022
Date of Patent:
January 17, 2023
Assignee:
INSTITUTE OF MICROBIOLOGY, GUANGDONG ACADEMY OF SCIENCES (GUANGDONG DETECTION CENTER OF MICR
Inventors:
Xiaobao Xie, Gang Zhou, Qingshan Shi, Yingsi Wang, Hong Peng, Sujuan Li
Abstract: Systems, methods, and storage media for generating a predicted discharge profile of a vehicle battery pack are disclosed. A method includes receiving, by a processing device, data pertaining to cells within a battery pack installed in each vehicle of a fleet of vehicles operating under a plurality of conditions, the data received from at least one of each vehicle in the fleet of vehicles, providing, by the processing device, the data to a machine learning server, directing, by the processing device, the machine learning server to generate a predictive model, the predictive model based on machine learning of the data, generating, by the processing device, the predicted discharge profile of the vehicle battery pack from the predictive model, and providing the discharge profile to an external device.
Type:
Grant
Filed:
February 25, 2019
Date of Patent:
January 17, 2023
Assignee:
TOYOTA RESEARCH INSTITUTE, INC.
Inventors:
Patrick K. Herring, Muratahan Aykol, Abraham Anapolsky
Abstract: A method for precoding to mitigate nonlinear distortions and a precoder for performing the same are disclosed. The precoder for mitigating distortions of a communication signal may include a filter configured to generate a filtering signal based on a third signal and filter coefficients corresponding to a selected signal generated based on a first signal, a second signal, and the third signal, and a modulo operator configured to generate the third signal by performing a modulo operation on the second signal, wherein the second signal is generated based on the first signal and the filtering signal.
Type:
Grant
Filed:
November 4, 2021
Date of Patent:
January 17, 2023
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: Systems and methods of treating meibomian and sebaceous gland dysfunction. The methods include reducing oxygen concentration in the environment of one or more dysfunctional meibomian and sebaceous glands, thereby restoring a hypoxic status of one or more dysfunctional meibomian and sebaceous glands. The reducing of the oxygen concentration is accomplished by restricting blood flow to the one or more dysfunctional meibomian and sebaceous glands and the environment of one or more dysfunctional meibomian sebaceous glands. The restricting of the blood flow is accomplished by contracting or closing one or more blood vessels around the one or more dysfunctional meibomian or sebaceous glands. The methods also include giving local or systemic drugs that lead to the generation of hypoxia-inducible factors in one or more dysfunctional meibomian and sebaceous glands.
Type:
Grant
Filed:
February 28, 2019
Date of Patent:
January 17, 2023
Assignee:
The Schepens Eye Research Institute, Inc.
Abstract: A method and a user equipment of performing resource switching in an unlicensed spectrum are provided. A current set of resources in the unlicensed spectrum is utilized by a UE for performing LBT attempts for transmission of an RACH message to a base station. One or more LBT attempts for transmissions from the UE to the base station are performed over the current set of resources during a current RACH procedure. The current set of resources is switched to a new set of resources in the unlicensed spectrum to be utilized by the UE in a new RACH procedure after a failure count reaches a pre-configured threshold during the current RACH procedure. The failure count is calculated at least based on a count of LBT failure over the current set of resources during the current RACH procedure.
Type:
Grant
Filed:
July 21, 2020
Date of Patent:
January 17, 2023
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: A deep-sea multi-energy integrated platform for complementary power generation, production, living and exploration includes a platform body and a sustainable power supply system, where the platform body includes a column cabin, an upper platform housing, a lower platform housing and a current guide column; the column cabin, the current guide column, the lower platform housing and the upper platform housing are mutually connected to form a triangular platform with a hollow cavity, and a net is disposed in the hollow cavity to form a mariculture zone; the sustainable power supply system includes a wind-driven generator disposed at an end of a top surface of the upper platform housing, a solar panel disposed above a middle portion of the top surface of the upper platform housing, a wave power generation apparatus disposed on the current guide column, and several tidal current power generation apparatuses.
Type:
Grant
Filed:
April 11, 2022
Date of Patent:
January 17, 2023
Assignee:
GUANGZHOU INSTITUTE OF ENERGY CONVERSION, CHINESE ACADEMY OF SCIENCES
Inventors:
Songwei Sheng, Kunlin Wang, Yin Ye, Hongjun Lin, Zhenpeng Wang, Bing Du
Abstract: A method for mitigating a leakage signal in an FMCW radar and a radar system thereof are disclosed. The method for mitigating the leakage signal in the radar system includes generating an in-phase signal and a quadrature signal for a beat signal, generating a complex signal using the in-phase signal and the quadrature signal, concentrating a phase noise of the leakage signal included in the complex signal on a stationary point, and mitigating the phase noise based on stationary point concentration (SPC) of the phase noise.
Type:
Grant
Filed:
July 9, 2020
Date of Patent:
January 17, 2023
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY