Patents Assigned to Instituto Bioclon, S.A. de C.V.
  • Compositions of F(ab?)antibody fragments
    Patent number: 8512706
    Abstract: The present invention is directed to a pharmaceutical composition comprising F(ab?)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab?)2 antibody fragments using scrum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab?)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: August 20, 2013
    Assignee: Instituto Bioclon, S.A. DE C.V.
    Inventors: Juan López De Silanes, Rita Guadalupe Mancilla Nava, Jorge F. Paniagua-Solís, Alejandro Alagon Cano, Walter J. García-Ubbelohde
  • Compositions of F(ab')2 Antibody Fragments
    Publication number: 20120064063
    Abstract: The present invention is directed to a pharmaceutical composition comprising F(ab?)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab?)2 antibody fragments using scrum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab?)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
    Type: Application
    Filed: November 17, 2011
    Publication date: March 15, 2012
    Applicant: Instituto Bioclon, S.A. de C.V.
    Inventors: Juan LOPEZ DE SILANES, Rita G. MANCILLA NAVA, Jorge F. PANIAGUA-SOLÍS, Alejandro ALAGÓN CANO, Walter GARCÍA UBBELOHDE
  • Pharmaceutical Composition of F(ab')2 Antibody Fragments and a Process for the Preparation Thereof
    Publication number: 20090142356
    Abstract: The present invention is directed to a pharmaceutical composition comprising F(ab?)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab?)2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab?)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
    Type: Application
    Filed: December 2, 2008
    Publication date: June 4, 2009
    Applicant: Instituto Bioclon, S.A. De C.V.
    Inventors: Juan LOPEZ DE SILANES, Rita G. MANCILLA NAVA, Jorge F. PANIAGUA SOLIS, Alejandro ALAGON CANO, Walter GARCIA UBBELOHDE
  • Pharmaceutical composition of F(ab')2 antibody fragments
    Patent number: 7485303
    Abstract: The present invention is directed to a pharmaceutical composition comprising F(ab?)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab?)2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab?)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: February 3, 2009
    Assignee: Instituto Bioclon, S.A. de C.V.
    Inventors: Juan Lopez de Silanes, Rita G Mancilla-Nava, Jorge F Paniagua-Solis
  • Pharmaceutical composition of F(ab1)2 antibody fragments and a process for the preparation thereof
    Patent number: 6709655
    Abstract: The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized, as a source of antibodies. The serum or blood plasma is digested with pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: March 23, 2004
    Assignee: Instituto Bioclon, S.A. de C.V.
    Inventors: Juan López de Silanes, Rita Mancilla Nava, Jorge F. Paniagua Solis