Patents Assigned to Instituto Biomar S.A.
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Publication number: 20220177484Abstract: Compounds of general formula wherein the wavy bond ˜ is either a double bond or the epoxide, or pharmaceutically acceptable salts, solvates, tautomers, or stereoisomers thereof, for use in the treatment of diseases associated with oxidative stress.Type: ApplicationFiled: March 12, 2020Publication date: June 9, 2022Applicant: INSTITUTO BIOMAR, S.AInventors: Antonio FERNÁNDEZ MEDARDE, María de los Ángeles VINUESA NAVARRO, José María SÁNCHEZ LÓPEZ, Juan Pedro BOLAÑOS HERNÁNDEZ, María de los Ángeles ALMEIDA PARRA, Emilio FERNÁNDEZ SÁNCHEZ
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Patent number: 8067441Abstract: The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.Type: GrantFiled: July 28, 2006Date of Patent: November 29, 2011Assignees: Neuropharma, S.A., Instituto Biomar, S.A.Inventors: Ana Martinez Gil, Paola Usan Egea, Miguel Medina Padilla, Esther Garcia Palomero, Julia Perez Baz, Rosa Isabel Fernandez Chimeno, Antonio Medarde Fernandez, Librada Maria Canedo Hernandez, Francisco Romero Millan, Ana Castro Morera, Mercedes Alonso Cascon, Jorge Sanchez Quesada
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Publication number: 20100184853Abstract: The present invention relates to the use of some terpenes, for example chlovalicin, ovalicin or fumagillin, as antifungal against Malassezia species and to their use in the manufacture of medicaments for the treatment of human skin diseases caused by these Malassezia species, such as pityriasis versicolor, seborrheic dermatitis, dandruff, atopic dermatitis, psoriasis, confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis.Type: ApplicationFiled: June 13, 2008Publication date: July 22, 2010Applicant: INSTITUTO BIOMAR, S.A.Inventors: Librada Maria Canedo Hernandez, Maria De Los Angeles Vinuesa-Navarro, Antonio Fernandez-Medarde
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Publication number: 20100048635Abstract: The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.Type: ApplicationFiled: July 28, 2006Publication date: February 25, 2010Applicants: Neuropharma, S.A., Instituto Biomar, S.A.Inventors: Ana Martinez Gil, Paola Egea, Miguel Medina Padilla, Esther Palomero, Julia Perez Baz, Rosa Fernandez Chimeno, Antonio Medarde Fernandez, Librada Canedo Hernandez, Francisco Romero Millan, Ana Castro Morera, Mercedes Alonso Cascon, Jorge Sanchez Quesada
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Publication number: 20080275088Abstract: The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.Type: ApplicationFiled: July 28, 2006Publication date: November 6, 2008Applicants: NEUROPHARMA, S.A., INSTITUTO BIOMAR, S.A.Inventors: Ana Martinez Gil, Paola Usan Egea, Miguel Medina Padilla, Esther Garcia Palomero, Julia Perez Baz, Rosa Isabel Fernandez Chimeno, Antonio Medarde Fernandez, Librada Maria Canedo Hernandez, Francisco Romero Millan, Ana Castro Morera, Mercedes Alonso Cascon, Jorge Sanchez Quesada
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Patent number: 7446094Abstract: Compounds of general formula (I) wherein R1, R2, R3 are as defined and R4 groups are each independently selected from NR2, O and S; are of use in treatment of cancers.Type: GrantFiled: June 23, 2004Date of Patent: November 4, 2008Assignee: Instituto Biomar S.A.Inventors: Paco Romero, Leyre Malet, Librada Maria Cañedo, Carmen Cuevas, José Fernando Reyes
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Publication number: 20060014776Abstract: Compounds of general formula I or a pharmaceutically acceptable salts, derivatives or prodrugs thereof are of use in treatment of cancer; wherein R1 and R2 are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, C2-C12 alkenylidene, substituted or unsubstituted C3-C12 alkynylidene and substituted or unsubstituted C2-C12 acyl.Type: ApplicationFiled: July 16, 2004Publication date: January 19, 2006Applicant: Instituto Biomar S.A.Inventors: Antonio Fernandez, Jesus De La Fuente, Sonia Manzanaro
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Patent number: 6852715Abstract: The invention provides compounds of formula (1) wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and R2 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.Type: GrantFiled: June 28, 2000Date of Patent: February 8, 2005Assignee: Instituto Biomar S.A.Inventors: Dolores Garcia Gravalos, Julia Perez, Librada Maria Cañedo, Francisco Romero, Fernando Espliego
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Patent number: 6812245Abstract: A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.Type: GrantFiled: June 9, 2003Date of Patent: November 2, 2004Assignee: Instituto Biomar S.A.Inventors: Librada Maria Cañedo, Dolores Garcia Gravalos, Francisco Romero, Fernando Espliego, Julia Perez-Baz
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Patent number: 6420357Abstract: Disclosed are the compounds Asamarine A and B, novel cytotoxic diterpene-alkaloids, that have been isolated from the sponge Raspailia sp. The structure of these compounds have been established on the basis of NMR data and confirmed by X-ray analysis. Also disclosed are compounds (I) and (II), wherein wherein R1 represents hydrogen or lower alkyl or lower alkanoyl; R2 represents hydrogen or lower alkyl; R3 is either an alkyl or a cycloalkyl group containing one or more isoprene units, or a monoterpene or a sesquiterpene or a sesquiterpene or a diterpene group; R4 or R5 represent hydrogen or lower alkyl; R6 represents lower alkyl; and X represents F or Cl or Br or I.Type: GrantFiled: June 22, 2001Date of Patent: July 16, 2002Assignee: Instituto Biomar, S.A.Inventors: Yoel Kashman, Amira Rudi, Tesfamariam Yosief, Dolores G. Gravalos
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Patent number: 6395711Abstract: The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.Type: GrantFiled: April 17, 2000Date of Patent: May 28, 2002Assignee: Instituto Biomar S.A.Inventors: Rosa Isabel Fernandez-Chimeno, Francisco Romero, Jose Luis Fernandez-Puentes, Julia Perez-Baz, Librada Maria Canedo, Fernando Espliego
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Patent number: 6391900Abstract: The present invention discloses new cytotoxic tris(oxazole)-containing macrolides having the formula: wherein X represents a lower alkyl; R1 and R2 represent hydrogen or lower alkyl; R3a represents hydrogen, and R3b represents or R3a and R3b together represent oxygen; R4 represents hydrogen, lower alkoxy or lower alkyl; R5 represents hydrogen, carbamoyl, or lower alkanoyl; R6a represents hydrogen, and R6b represents hydroxy, or R6a and R6b together represent oxygen; R7 represents hydrogen, lower alkyl, or hydroxymethyl; R8 represents lower alkoxy or lower alkyl; Y1 represents hydrogen or methyl, and y2 represents hydrogen, or Y1 and Y2 together represent a double bond. Also disclose are methods for treating mammals using the macrolides and pharmaceutical preparations including the macrolides.Type: GrantFiled: January 12, 2001Date of Patent: May 21, 2002Assignee: Instituto Biomar S.A.Inventors: Tatsuo Higa, Dolores Garcia Gravalos, Jose Luis Fernandez Puentes
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Patent number: 6350743Abstract: Shermilamine D, a novel cytotoxic pyridoacridine alkaloid of Formula 1, has been isolated from the tunicate Cystodytes violatinctus. The structure of the compound has been established on the basis of 1-D and 2-D NMR data.Type: GrantFiled: February 22, 2001Date of Patent: February 26, 2002Assignee: Instituto Biomar, S.A.Inventors: Yoel Kashman, Ganit Koren-Goldshlager, Maurice Aknin, Dolores Garcia Gravalos